Overexpression of tissue inhibitor of metalloproteinases-2 by retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion

Cancer Research

Volumn 56, Issue 13, 1996, Pages 2891-2895

  Imren, Suzan ^a   Kohn, Donald B ^a,b   Shimada, Hiroyuki ^b   Blavier, Laurence ^a   DeClerck, Yves A ^a,b,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; METALLOPROTEINASE;

ARTICLE; CANCER INVASION; ENZYME ACTIVITY; ESCHERICHIA COLI; FIBROBLAST; GENE EXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; RETROVIRUS; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE; TUMOR GROWTH;

3T3 CELLS; ANIMALS; CELL DIVISION; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HUMANS; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PROTEIN BIOSYNTHESIS; PROTEINS; RATS; RETROVIRIDAE; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSDUCTION, GENETIC; TRANSFECTION;

EID: 0030012534     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Matrisian, L M. The matrix degrading metalloproteinases. Bioessays, 14: 455-463, 1992.
2. Murphy, G , and Docherty, A. J. The matrix metalloproteinases and their inhibitors. Am. J. Respir Cell Mol. Biol., 7: 120-125, 1992.
3. Sympson, C. J., Talhouk, R. S., Alexander, C. M., Chin, J. R., Clift, S. M., Bissell, M. J., and Wert, Z. Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression J. Cell Biol., 125: 681-693, 1994.
4. Stetler-Stevenson, W. G , Aznavoorian, S., and Liotta, L. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu. Rev. Cell Biol., 4: 541-573, 1993.
5. Powell, W C., Knox, J. D., Navre, M., Grogan, T. M., Kittelson, J., Nagle, R. B., and Bowden, G. T. Expression of the metalloproteinase matrilysin in DU-145 cells increases their invasive potential in severe combined immunodeficient mice. Cancer Res., 53: 417-422, 1993.
6. Bernhard, E. J., Gruber, S B , and Muschel, R J. Direct evidence linking expression of matrix metalloproteinase 9 (92 kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc. Natl. Acad. Sci. USA, 91: 4293-4297, 1994.
7. Witty, J. P , McDonnell, S., Newell, K. J., Cannon, P., Navre, M., Tressler, R. J., and Matrisian, L. M Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo. Cancer Res., 54: 4805-4812, 1994.
8. DeClerck, Y. A., Perez, N., Shimada, H., Boone, T. C., Langley, K. E., and Taylor, S. M. Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases Cancer Res, 52: 701-708, 1992.
9. Montgomery, A. M., Mueller, B. M., Reisfeld, R. A., Taylor, S. M., and DeClerck, Y. A. Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line. Cancer Res., 54: 5467-5473, 1994.
10. Ram, Z., Culver, K. W., Walbridge, S., Blaese, R. M , and Oldfield, E. H. In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats Cancer Res., 53: 83-88, 1993.
11. Liu, T J., Zhang, W. W., Taylor, D. L., Roth, J. A., Goepfert, H , and Clayman, G. L. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res., 54: 3662-3667, 1994.
12. Nabel G. J., Nabel, E G., Yang, Z. Y., Fox, B. A., Plautz, G. E., Gao, X., Huang, L., Shu, S., Gordon, D., and Chang, A. E. Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc. Natl. Acad. Sci. USA, 90: 11307-11311, 1993.
13. Crystal, R. G. Transfer of genes to humans: early lessons and obstacles to success. Science (Washington DC), 270: 404-410, 1995.
14. Markowitz, D., Goff, S., and Bank, A. A safe packaging line for gene transfer separating viral genes on two different plasmids. J. Virol., 62. 1120-1124, 1988.
15. Miller, A. D., and Buttimore, C Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production Mol. Cell Biol., 6: 2895-2902, 1986.
16. 35S for labeling probes used in in situ hybridization. Biotechniques, 15: 506-511, 1993.
17. De Clerck, Y. A. Purification and characterization of a collagenase inhibitor produced by bovine vascular smooth muscle cells. Arch. Biochem. Biophys., 265: 28-37, 1988
18. Stetler-Stevenson, W. G., Brown, P. D., Onisto, M., Levy, A. T., and Liotta, L. A. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues J Biol. Chem., 265: 13933-13938, 1990.
19. Khokha, R. Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1. J. Natl. Cancer Inst., 86: 299-304, 1994.
20. DeClerck, Y. A., and Imren, S. Protease inhibitors: role and potential therapeutic use in human cancer. Eur J. Cancer, 30A 2170-2180, 1994.
21. Davies, B., Brown, P D., East, N , Crimmin, M. J , and Balkwill, F. K. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res., 53: 2087-2091, 1993.
22. Wang, X , Fu, X., Brown, P. D , Crimmin, M. J., and Hoffman, R M Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res , 54: 4726-4728, 1994.
23. Roeb, E., Rose John, S., Erren, A., Edwards, D. R , Matern, S., Graeve, L , and Heinrich, P. C. Tissue inhibitor of metalloproteinases-2 (TIMP-2) in rat liver cells is increased by lipopolysaccharide and prostaglandin E2. FEBS Lett., 357. 33-36, 1995.