The ROP-Syntaxin interaction inhibits neurotransmitter release

European Journal of Cell Biology

Volumn 80, Issue 2, 2001, Pages 196-199

  Wu, Mark N ^a   Schulze, Karen L ^a   Lloyd, Thomas E ^a   Bellen, Hugo J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ANTIBODY; ARGININE; CYSTEINE; DODECYL SULFATE SODIUM; GLUTATHIONE TRANSFERASE; IODINE 125; ISOLEUCINE; MUTANT PROTEIN; NEUROTRANSMITTER; PYROXYLIN; SEPHAROSE; SYNAPTOTAGMIN; SYNTAXIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIBODY LABELING; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHEMOLUMINESCENCE; CONTROLLED STUDY; HYDROPHOBICITY; LETTER; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; POINT MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN IMMOBILIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; RAT;

EID: 0035115571     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-9335-00143     Document Type: Letter

References (24)

1. Sec1p binds to SNARE complexes and concentrates at sites of secretion
2. 2+ regulates the interaction between synaptotagmin and syntaxin 1
3. 2+ and assembly with the core SNARE complex onto membranes
4. Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A
5. Mutations in the Drosophila Rop gene suggest a function in general secretion and synaptic transmission
6. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin
7. Sec1/Munc18 proteins: Mediators of membrane fusion moving to center stage
8. Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociation
9. Localization of synaptotagmin-binding domains on syntaxin
10. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
11. The relation of protein binding to function: What is the significance of munc18 and synaptotagmin binding to syntaxin 1, and where are the corresponding binding sites?
12. Raster3D version 2.0: A program for photorealistic molecular graphics
13. Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex
14. Protein-protein interactions in neurotransmitter release
15. Overexpression of cysteine-string proteins in Drosophila reveals interactions with syntaxin
16. Specificity and regulation of a synaptic vesicle docking complex
17. Rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo
18. 2+-dependent electrostatic switch
19. The synaptic vesicle cycle: A cascade of protein-protein interactions
20. 2+ ions bind to the tip of a C2-domain?
21. Synaptic assembly of the brain in the absence of neurotransmitter secretion
22. Erratum
23. Syntaxin-1 A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo
24. ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner