Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: The myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15

Chemistry and Biology

Volumn 8, Issue 1, 2001, Pages 59-69

  Silakowski, Barbara ^a,b   Nordsiek, Gabriele ^a   Kunze, Brigitte ^a   Blöcker, Helmut ^a   Müller, Rolf ^a,b  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Biosynthetic gene cluster; Myxalamid; Myxobacterium; Polyketide synthase peptide synthetase; Reductive chain termination

Indexed keywords

ACYLTRANSFERASE; AMINO TERMINAL SEQUENCE; BACTERIAL DNA; CONSENSUS SEQUENCE; ELECTRON TRANSPORT; GENETIC REGULATION; MOLECULAR CLONING; NONRIBOSOMAL PEPTIDYL SYNTHETASE; POLYKETIDE SYNTHASE; SECONDARY METABOLITE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CLONING, MOLECULAR; DNA PRIMERS; GENES, BACTERIAL; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MULTIGENE FAMILY; PEPTIDE SYNTHASES; POLYENES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STIGMATELLA AURANTIACA;

BACILLI; MYXOCOCCALES; STIGMATELLA AURANTIACA; STREPTOMYCINEAE;

EID: 0035113529     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00056-9     Document Type: Article

References (49)

1. Polyketide and nonribosomal polypeptide biosynthesis
2. Biology of the myxobacteria: Ecology and taxonomy
3. Production of bioactive secondary metabolites
4. Myxobacteria as producers of secondary metabolites
5. New lessons for combinatorial biosynthesis from Myxobacteria: The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1
6. The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
7. Cloning and heterologous expression of the epothilon gene cluster
8. Genetic contributions to understanding polyketide synthases
9. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis
10. The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin
11. Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of genes flanking the polyketide synthase
12. Biosynthesis of ansatrienin (mycotrienin) and naphtomycin: Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus TÜ 1892
13. Bleomycin biosynthesis in Streptomyces verticillus ATCC15003: A model of hybrid peptide and polyketide biosynthesis
14. Iron acquisition in plague: Modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis
15. Polyketide synthase gene coupled to the peptide synthetase module involved in the biosynthesis of the cyclic heptapeptide microcystin
16. The mycosubtilin synthetase of Bacillus subtilis ATCC6633: A multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase
17. The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases
18. Myxothiazol, an antibiotic from Myxococcus fulvus (myxobacterales). I. Cultivation, isolation, physico-chemical and biological properties
19. The myxalamids, new antibiotics from Myxococcus xanthus (myxobacterales). I. Production, physico-chemical and biological properties, and mechanism of action
20. Metabolic diversity in myxobacteria - Identification of the myxalamid and the stigmatellin biosynthetic gene cluster of Stigmatella aurantiaca Sga15 and a combined polyketide-(poly)peptide gene cluster from the epothilon producing strain Sorangium cellulosum So ce90
21. Phenalamide, neue HIV-Inhibitoren aus Myxococcus stipitatus Mx s40
22. Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis
23. Modular organization of genes required for complex polyketide biosynthesis
24. How do peptide synthetases generate structural diversity?
25. Products of secondary metabolism
26. The myxobacterial genome
27. Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of genes flanking the polyketide synthase
28. Biosynthesis of the ansamycin antibiotic rifamycin: Deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699
29. The biosynthetic potential of the myxobacteria
30. Divergent structural motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acylcarrier protein transacylase domains in the modular polyketide synthases
31. Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis
32. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units
33. Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis
34. The animal fatty acid synthase: One gene, one polypeptide, seven enzymes
35. Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis
36. Dissecting and exploiting intermodular communication in polyketide synthases
37. Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
38. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
39. The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
40. Characterization of the lys2 gene of Penicillium chrysogenum encoding α-aminoadipic acid reductase
41. Lysine biosynthesis in Saccharomyces cerevisiae: Mechanism of α-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5
42. The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sga15
43. Two multifunctional peptide synthetases and an O-methyltransferase are involved in the biosynthesis of the DNA-binding antibiotic and antitumour agent saframycin Mx1 from Myxococcus xanthus
44. fbfB, a gene encoding a putative galactose oxidase, is involved in Stigmatella aurantiaca fruiting body formation
45. Rapid isolation of genomic DNA from Gram negative bacteria
46. A new DNA sequence assembly program
47. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
48. Analysis of a Het-mutation in Anabaena sp. strain PCC 7120 implicates a secondary metabolite in the regulation of heterocyst spacing