Efficient human immunodeficiency virus-based vector transduction of unstimulated human mobilized peripheral blood CD34+ cells in the SCID-hu Thy/Liv model of human T cell lymphopoiesis

Human Gene Therapy

Volumn 12, Issue 4, 2001, Pages 401-413

  Douglas, Janet L ^a   Lin, Wei Yu ^a   Panis, Marites L ^a   Veres, Gabor ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CYTOKINE; GREEN FLUORESCENT PROTEIN; PHOSPHOGLYCERATE KINASE; VIRUS GLYCOPROTEIN; VIRUS VECTOR;

ANIMAL EXPERIMENT; ARTICLE; CELL DIVISION; CONTROLLED STUDY; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; LYMPHOPOIESIS; MARKER GENE; MURINE LEUKEMIA VIRUS; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; SCID MOUSE; T LYMPHOCYTE; THYMOCYTE; TRANSGENE; VESICULAR STOMATITIS VIRUS; VIRUS ENVELOPE;

ANIMALS; ANTIGENS, CD34; CELL LINE; CYTOKINES; DISEASE MODELS, ANIMAL; GENE DOSAGE; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEMATOPOIETIC STEM CELLS; HIV-1; HUMANS; LEUKEMIA VIRUS, MURINE; LIVER; LUMINESCENT PROTEINS; MICE; MICE, SCID; PHOSPHOGLYCERATE KINASE; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); T-LYMPHOCYTES; THYMUS GLAND; TRANSDUCTION, GENETIC; TRANSGENES; VESICULAR STOMATITIS-INDIANA VIRUS; VIRAL ENVELOPE PROTEINS; VIRUS REPLICATION;

AMPHOTROPIC MURINE LEUKEMIA VIRUS; ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; LENTIVIRUS; MURINAE; UNIDENTIFIED RETROVIRUS; VESICULAR STOMATITIS VIRUS;

EID: 0035111667     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340150504028     Document Type: Article

References (49)

1. + cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein G
2. + cells
3. Centrifugal enhancement of retroviral-mediated gene transfer
4. Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture
5. RevM10-expressing T cells derived in vivo from transduced human hematopoietic stem-progenitor cells inhibit human immunodeficiency virus replication
6. − bone marrow cells with multilineage potential at the single cell level: Key role of thrombopoietin
7. The human immunodeficiency virus type 1 Tat protein transactivates tumor necrosis factor beta gene expression through a TAR-like structure
8. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells
9. − human hematopoietic cells by HIV-1 based lentiviral vectors
10. The amphotropic murine leukemia virus receptor gene encodes a 71-kilodalton protein that is induce by phosphate depletion
11. Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease
12. A third-generation lentivirus vector with a conditional packaging system
13. + cells in non-obese diabetic/severe combined immune-deficient mice
14. Transduction of hematopoietic cells by foamy virus vectors
15. Repression of MHC class I gene promoter activity by two-exon Tat of HIV
16. Minimum requirements for efficient transduction of dividing and nondividing cells by feline immunodeficiency virus vectors
17. High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations
18. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors
19. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters
20. Minimal requirement for a lentivirus vector based on human immunodeficiency virus type 1
21. Cell cycle state, response to hemopoietic growth factors and retroviral vector-mediated transduction of human hemopoietic stem cells
22. Efficient transduction by an amphotropic retrovirus vector is dependent on high-level expression of the cell surface virus receptor
23. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein
24. − cells with preserved ability to engraft in SCID-hu bone
25. Improved retroviral vectors for gene transfer and expression
26. Stable gene transfer to the nervous system using a non-primate lentiviral vector
27. + cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors
28. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
29. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
30. Long-term human hematopoiesis in the SCID-hu mouse
31. Gene transfer vectors derived from equine infectious anemia virus
32. The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction
33. Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway
34. Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity
35. Analysis in human immunodeficiency virus type 1 vectors of cis-acting sequences that affect gene transfer into human lymphocytes
36. Identification of a human immunodeficiency virus type 2 (HIV-2) encapsidation determinant and transduction of nondividing human cells by HIV-2-based lentivirus vectors
37. Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors
38. Gene transfer into human lymphocytes by a defective human immunodeficiency virus type 1 vector
39. A novel amphotropic packaging cell line: High titer, complement resistance, and improved safety
40. Inhibition of VSV binding and infectivity by phosphatidylserine: Is phosphatidylserine a VSV-binding site?
41. Development of a self-inactivating, minimal lentivirus vector based on simian immunodeficiency virus
42. Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells
43. Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished long-term repopulating ability
44. 1 human hematopoietic stem cells
45. Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells
46. A general method for the generation of high-titer, pantropic retroviral vectors: Highly efficient infection of primary hepatocytes
47. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
48. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
49. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors