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Volumn 10, Issue 5, 1998, Pages 614-619

Genetic control of cell differentiation in the skeleton

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOPROTEGERIN; PROTEIN; UNCLASSIFIED DRUG;

EID: 0031671856     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(98)80037-9     Document Type: Article
Times cited : (119)

References (50)
  • 1
    • 0029945149 scopus 로고    scopus 로고
    • Limbs: A model for pattern formation within the vertebrate body plan
    • Cohn MJ, Tickle C. Limbs: a model for pattern formation within the vertebrate body plan. Trends Genet. 12:1996;253-258.
    • (1996) Trends Genet , vol.12 , pp. 253-258
    • Cohn, M.J.1    Tickle, C.2
  • 2
    • 0029737070 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
    • Hogan BLM. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10:1996;1580-1594.
    • (1996) Genes Dev , vol.10 , pp. 1580-1594
    • Hogan, B.L.M.1
  • 3
    • 0025881362 scopus 로고
    • Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development
    • Tabin CJ. Retinoids, homeoboxes, and growth factors: toward molecular models for limb development. Cell. 66:1991;199-217.
    • (1991) Cell , vol.66 , pp. 199-217
    • Tabin, C.J.1
  • 4
    • 0026757845 scopus 로고
    • The membranous skeleton: The role of cell condensations in vertebrate skeletogenesis
    • Hall BK, Miyake T. The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis. Anat Embryol. 186:1992;107-124.
    • (1992) Anat Embryol , vol.186 , pp. 107-124
    • Hall, B.K.1    Miyake, T.2
  • 5
    • 0002623547 scopus 로고
    • Morphology of connective tissue: Cartilage
    • New York: Wiley-Liss, Inc
    • Horton WA. Morphology of connective tissue: cartilage. Connective Tissue and Its Heritable Disorders. 1993;73-84 Wiley-Liss, Inc, New York
    • (1993) Connective Tissue and Its Heritable Disorders , pp. 73-84
    • Horton, W.A.1
  • 6
    • 0029078901 scopus 로고
    • Tissue-specific and differential expression of alternatively spliced alpha 1(II) collagen mRNAs in early human embryos
    • Lui VC, Ng LJ, Nicholls J, Tam PP, Cheah KS. Tissue-specific and differential expression of alternatively spliced alpha 1(II) collagen mRNAs in early human embryos. Dev Dyn. 203:1995;198-211.
    • (1995) Dev Dyn , vol.203 , pp. 198-211
    • Lui, V.C.1    Ng, L.J.2    Nicholls, J.3    Tam, P.P.4    Cheah, K.S.5
  • 7
    • 0025346774 scopus 로고
    • Differential expression of a cystein-rich domain in the amino-terminal propeptide of type II (cartilage) procollagen by alternative splicing of mRNA
    • Ryan MC, Sandell LJ. Differential expression of a cystein-rich domain in the amino-terminal propeptide of type II (cartilage) procollagen by alternative splicing of mRNA. J Biol Chem. 265:1990;10334-10339.
    • (1990) J Biol Chem , vol.265 , pp. 10334-10339
    • Ryan, M.C.1    Sandell, L.J.2
  • 8
    • 0025948422 scopus 로고
    • Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: Differential expression of the amino-propeptide
    • Sandell LJ, Morris N, Robbins JR, Goldring MB. Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: differential expression of the amino-propeptide. J Cell Biol. 114:1991;1307-1319.
    • (1991) J Cell Biol , vol.114 , pp. 1307-1319
    • Sandell, L.J.1    Morris, N.2    Robbins, J.R.3    Goldring, M.B.4
  • 9
    • 0028939397 scopus 로고
    • The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development
    • Luo G, D'Souza R, Hogue D, Karsenty G. The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development. J Bone Miner Res. 10:1995;325-334.
    • (1995) J Bone Miner Res , vol.10 , pp. 325-334
    • Luo, G.1    D'Souza, R.2    Hogue, D.3    Karsenty, G.4
  • 10
    • 0001269091 scopus 로고
    • Differentiation and morphogenesis of cranial skeletal tissues
    • J. Hanken, Hall B.K. Chicago: University of Chicago Press
    • Thorogood P. Differentiation and morphogenesis of cranial skeletal tissues. Hanken J, Hall BK. The Skull. 1993;University of Chicago Press, Chicago.
    • (1993) The Skull
    • Thorogood, P.1
  • 11
    • 0029792565 scopus 로고    scopus 로고
    • Analysis of chondroprogenitor frequency and cartilage differentiation in a novel family of clonal chondrogenic rat cell lines
    • Grigoriadis AE, Heersche JNM, Aubin JE. Analysis of chondroprogenitor frequency and cartilage differentiation in a novel family of clonal chondrogenic rat cell lines. Differentiation. 60:1996;299-307.
    • (1996) Differentiation , vol.60 , pp. 299-307
    • Grigoriadis, A.E.1    Heersche, J.N.M.2    Aubin, J.E.3
  • 12
    • 85003152202 scopus 로고
    • Modulation of osteoclast differentiation
    • Suda T, Takaharashi N, Martin TJ. Modulation of osteoclast differentiation. Endocr Rev. 13:1992;66-80.
    • (1992) Endocr Rev , vol.13 , pp. 66-80
    • Suda, T.1    Takaharashi, N.2    Martin, T.J.3
  • 13
    • 0031104994 scopus 로고    scopus 로고
    • SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse
    • of outstanding interest. This paper provides an extensive study of Sox9 and type II collagen gene coexpression during mouse development. This paper also shows that Sox9 can bind and activate transcription through a consensus SOX/SRY element
    • Ng LJ, Wheatley S, Muscat GE, Conway-Campbell J, Bowles J, Wright E, Bell DM, Tam PP, Cheah KS, Koopman P. SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. of outstanding interest Dev Biol. 183:1997;108-121 This paper provides an extensive study of Sox9 and type II collagen gene coexpression during mouse development. This paper also shows that Sox9 can bind and activate transcription through a consensus SOX/SRY element.
    • (1997) Dev Biol , vol.183 , pp. 108-121
    • Ng, L.J.1    Wheatley, S.2    Muscat, G.E.3    Conway-Campbell, J.4    Bowles, J.5    Wright, E.6    Bell, D.M.7    Tam, P.P.8    Cheah, K.S.9    Koopman, P.10
  • 14
    • 0030855005 scopus 로고    scopus 로고
    • Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis
    • Zhao Q, Eberspaecher H, Lefebvre V, De Crombrugghe B. Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis. Dev Dyn. 209:1997;377-386.
    • (1997) Dev Dyn , vol.209 , pp. 377-386
    • Zhao, Q.1    Eberspaecher, H.2    Lefebvre, V.3    De Crombrugghe, B.4
  • 16
    • 0030899814 scopus 로고    scopus 로고
    • SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene
    • of outstanding interest. Identification of a Sox9 binding site in the first intron of the mouse type II collagen gene is reported here. In vitro and in vivo demonstration of the transcriptional activity of this element is also described
    • Lefebvre V, Huang W, Harley VR, Goodfellow PN, de Crombrugghe B. SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. of outstanding interest Mol Cell Biol. 17:1997;2336-2346 Identification of a Sox9 binding site in the first intron of the mouse type II collagen gene is reported here. In vitro and in vivo demonstration of the transcriptional activity of this element is also described.
    • (1997) Mol Cell Biol , vol.17 , pp. 2336-2346
    • Lefebvre, V.1    Huang, W.2    Harley, V.R.3    Goodfellow, P.N.4    De Crombrugghe, B.5
  • 17
    • 0031003272 scopus 로고    scopus 로고
    • SOX9 directly regulates the type-II collagen gene
    • of outstanding interest. This paper describes the in vitro characterization of a Sox9 binding site in the first intron of the mouse type II collagen gene. It also provides a demonstration in vivo that ectopic expression of Sox9 can transactivate type II collagen gene expression
    • Bell DM, Leung KK, Wheatley SC, Ng LJ, Zhou S, Ling KW, Sham MH, Koopman P, Tam PP, Cheah KS. SOX9 directly regulates the type-II collagen gene. of outstanding interest Nat Genet. 16:1997;174-178 This paper describes the in vitro characterization of a Sox9 binding site in the first intron of the mouse type II collagen gene. It also provides a demonstration in vivo that ectopic expression of Sox9 can transactivate type II collagen gene expression.
    • (1997) Nat Genet , vol.16 , pp. 174-178
    • Bell, D.M.1    Leung, K.K.2    Wheatley, S.C.3    Ng, L.J.4    Zhou, S.5    Ling, K.W.6    Sham, M.H.7    Koopman, P.8    Tam, P.P.9    Cheah, K.S.10
  • 21
    • 0028943780 scopus 로고
    • A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia
    • Schipani E, Kruse K, Juppner H. A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science. 268:1995;98-100.
    • (1995) Science , vol.268 , pp. 98-100
    • Schipani, E.1    Kruse, K.2    Juppner, H.3
  • 22
    • 0028837742 scopus 로고
    • Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
    • Bitgood MJ, McMahon AP. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol. 172:1993;126-138.
    • (1993) Dev Biol , vol.172 , pp. 126-138
    • Bitgood, M.J.1    McMahon, A.P.2
  • 23
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science. 273:1996;613-622.
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 25
    • 0029935895 scopus 로고    scopus 로고
    • Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia
    • Naski MC, Wang Q, Xu J, Ornitz DM. Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet. 13:1996;233-237.
    • (1996) Nat Genet , vol.13 , pp. 233-237
    • Naski, M.C.1    Wang, Q.2    Xu, J.3    Ornitz, D.M.4
  • 26
    • 0029928791 scopus 로고    scopus 로고
    • Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
    • Colvin JS, Bohne BA, Harding GW, McEwen DG, Ornitz DM. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet. 12:1996;390-397.
    • (1996) Nat Genet , vol.12 , pp. 390-397
    • Colvin, J.S.1    Bohne, B.A.2    Harding, G.W.3    McEwen, D.G.4    Ornitz, D.M.5
  • 27
    • 0346963598 scopus 로고    scopus 로고
    • MMP-9/Gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chomdrocytes
    • of outstanding interest. Targeted inactivation of the Gelatinase B gene in mice is described in this paper. Homozygous mutants first exhibit delayed apoptosis of the hypertrophic chondrocytes, vascularization and ossification. In older animals these process take place aberrantly. Gelatinase B is shown to be synthesized by a novel cell type of bone marrow origin, the chondroclast
    • Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, Shapiro SD, Senior RM, Werb Z. MMP-9/Gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chomdrocytes. of outstanding interest Cell. 93:1998;411-422 Targeted inactivation of the Gelatinase B gene in mice is described in this paper. Homozygous mutants first exhibit delayed apoptosis of the hypertrophic chondrocytes, vascularization and ossification. In older animals these process take place aberrantly. Gelatinase B is shown to be synthesized by a novel cell type of bone marrow origin, the chondroclast.
    • (1998) Cell , vol.93 , pp. 411-422
    • Vu, T.H.1    Shipley, J.M.2    Bergers, G.3    Berger, J.E.4    Helms, J.A.5    Hanahan, D.6    Shapiro, S.D.7    Senior, R.M.8    Werb, Z.9
  • 28
    • 0028927556 scopus 로고
    • Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene
    • Ducy P, Karsenty G. Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol. 15:1995;1858-1869.
    • (1995) Mol Cell Biol , vol.15 , pp. 1858-1869
    • Ducy, P.1    Karsenty, G.2
  • 29
    • 0029417351 scopus 로고
    • A PEBP2/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element
    • Geoffroy V, Ducy P, Karsenty G. A PEBP2/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element. J Biol Chem. 270:1995;30973-30979.
    • (1995) J Biol Chem , vol.270 , pp. 30973-30979
    • Geoffroy, V.1    Ducy, P.2    Karsenty, G.3
  • 30
    • 0028874666 scopus 로고
    • The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/Runt domain transcription factor family: Interactions with the osteocalcin gene promoter
    • Merriman HL, van Wijnen AJ, Hiebert S, Bidwell JP, Fey E, Lian J, Stein J, Stein GS. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/Runt domain transcription factor family: interactions with the osteocalcin gene promoter. Biochemistry. 34:1995;13125-13132.
    • (1995) Biochemistry , vol.34 , pp. 13125-13132
    • Merriman, H.L.1    Van Wijnen, A.J.2    Hiebert, S.3    Bidwell, J.P.4    Fey, E.5    Lian, J.6    Stein, J.7    Stein, G.S.8
  • 31
    • 0021849474 scopus 로고
    • The localized requirements for a gene affecting segmentation in Drosophila: Analysis of larvae mosaic for runt
    • Gergen JP, Wieschaus E. The localized requirements for a gene affecting segmentation in Drosophila: analysis of larvae mosaic for runt. Dev Biol. 109:1985;321-335.
    • (1985) Dev Biol , vol.109 , pp. 321-335
    • Gergen, J.P.1    Wieschaus, E.2
  • 33
    • 0000335533 scopus 로고    scopus 로고
    • The runt domain transcription factor PEBP2/CBF, and its involvment in human leukemia
    • M. Yaniv, Ghysdael J. Basel: Birkhauser Verlag
    • Ito Y, Bae S-C. The runt domain transcription factor PEBP2/CBF, and its involvment in human leukemia. Yaniv M, Ghysdael J. Oncogenes as Transcriptional Regulators. 2:1997;107-132 Birkhauser Verlag, Basel.
    • (1997) Oncogenes As Transcriptional Regulators , vol.2 , pp. 107-132
    • Ito, Y.1    Bae S-C2
  • 35
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • of outstanding interest. This paper reports the cloning of Osf2/Cbfa1 cDNA and provides molecular evidence that it acts as a transcriptional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffroy V, Ridall A, Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. of outstanding interest Cell. 89:1997;747-754 This paper reports the cloning of Osf2/Cbfa1 cDNA and provides molecular evidence that it acts as a transcriptional activator of osteoblast differentiation.
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.4    Karsenty, G.5
  • 36
    • 0030666372 scopus 로고    scopus 로고
    • Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    • of outstanding interest. This paper shows the requirement of Cbfa1 for osteoblast differentiation during embryogenesis using targeted disruption of the Cbfa1 gene in mice. It also establishes the genetic link between Cbfa1 and the CCD phenotype in mice
    • Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GWH, Beddington RSP, Mundlos S, Olsen BR, et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. of outstanding interest Cell. 89:1997;765-771 This paper shows the requirement of Cbfa1 for osteoblast differentiation during embryogenesis using targeted disruption of the Cbfa1 gene in mice. It also establishes the genetic link between Cbfa1 and the CCD phenotype in mice.
    • (1997) Cell , vol.89 , pp. 765-771
    • Otto, F.1    Thornell, A.P.2    Crompton, T.3    Denzel, A.4    Gilmour, K.C.5    Rosewell, I.R.6    Stamp, G.W.H.7    Beddington, R.S.P.8    Mundlos, S.9    Olsen, B.R.10
  • 37
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • of outstanding interest. This study shows the requirement of Cbfa1 for osteoblast differentiation and osteoblast-specific gene expression during embryogenesis using targeted disruption of the Cbfa1 gene in mice
    • Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao Y-H, Inada M, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. of outstanding interest Cell. 89:1997;755-764 This study shows the requirement of Cbfa1 for osteoblast differentiation and osteoblast-specific gene expression during embryogenesis using targeted disruption of the Cbfa1 gene in mice.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4    Sasaki, K.5    Deguchi, K.6    Shimizu, Y.7    Bronson, R.T.8    Gao Y-H9    Inada, M.10
  • 38
    • 15444351110 scopus 로고    scopus 로고
    • Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
    • of outstanding interest. This paper is particularly important because it shows that cleidocranial dysplasia is caused by haploinsufficiency. It reports the characterization of deletions, stop codon and insertion mutations in the CBFA1 gene of cleidocranial dysplasia patients
    • Mundlos S, Otto F, Mundlos C, Mulliken JB, Aylsworth AS, Albright S, Lindhout D, Cole WG, Henn W, Knoll JHM, et al. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. of outstanding interest Cell. 89:1997;773-779 This paper is particularly important because it shows that cleidocranial dysplasia is caused by haploinsufficiency. It reports the characterization of deletions, stop codon and insertion mutations in the CBFA1 gene of cleidocranial dysplasia patients.
    • (1997) Cell , vol.89 , pp. 773-779
    • Mundlos, S.1    Otto, F.2    Mundlos, C.3    Mulliken, J.B.4    Aylsworth, A.S.5    Albright, S.6    Lindhout, D.7    Cole, W.G.8    Henn, W.9    Knoll, J.H.M.10
  • 39
    • 0030927622 scopus 로고    scopus 로고
    • Missense mutations abolishing DNA binding OSF2/CBFA1 in patients affected with cleidocranial dysplasia
    • of outstanding interest. This paper reports the characterization of missense mutations in the DNA-binding domain encoding region of the CBFA1 gene in cleidocranial dysplasia patients
    • Lee B, Thirunavukkarasu K, Zhou L, Pastore L, Baldini A, Geoffroy V, Ducy P, Karsenty G. Missense mutations abolishing DNA binding OSF2/CBFA1 in patients affected with cleidocranial dysplasia. of outstanding interest Nat Genet. 16:1997;307-311 This paper reports the characterization of missense mutations in the DNA-binding domain encoding region of the CBFA1 gene in cleidocranial dysplasia patients.
    • (1997) Nat Genet , vol.16 , pp. 307-311
    • Lee, B.1    Thirunavukkarasu, K.2    Zhou, L.3    Pastore, L.4    Baldini, A.5    Geoffroy, V.6    Ducy, P.7    Karsenty, G.8
  • 40
    • 0030933226 scopus 로고    scopus 로고
    • Osteopetrosis in mice lacking haematopoietic transcription factor PU.1
    • of outstanding interest. This paper reports the targeted inactivation of the PU.1 gene in mice. Homozygous PU.1 mutants present with severe osteopetrosis and lack both macrophages and osteoclasts
    • Tondravi MM, McKercher SR, Anderson K, Erdmann JM, Quiroz M, Maki R, Teitelbaum SL. Osteopetrosis in mice lacking haematopoietic transcription factor PU.1. of outstanding interest Nature. 386:1997;81-84 This paper reports the targeted inactivation of the PU.1 gene in mice. Homozygous PU.1 mutants present with severe osteopetrosis and lack both macrophages and osteoclasts.
    • (1997) Nature , vol.386 , pp. 81-84
    • Tondravi, M.M.1    McKercher, S.R.2    Anderson, K.3    Erdmann, J.M.4    Quiroz, M.5    Maki, R.6    Teitelbaum, S.L.7
  • 42
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • of outstanding interest. Identification of osteoprogerin (OPG), a soluble factor related to the TNF receptor family, that blocks osteoclastogenesis in vitro is reported. Overexpression of OPG gene in mice leads to increased bone density
    • Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. of outstanding interest Cell. 89:1997;309-319 Identification of osteoprogerin (OPG), a soluble factor related to the TNF receptor family, that blocks osteoclastogenesis in vitro is reported. Overexpression of OPG gene in mice leads to increased bone density.
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3    Kelley, M.4    Chang, M.S.5    Luthy, R.6    Nguyen, H.Q.7    Wooden, S.8    Bennett, L.9    Boone, T.10
  • 43
    • 0032079445 scopus 로고    scopus 로고
    • Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    • of special interest. Targeted inactivation of the osteoprotegerin (OPG) gene in mice is described. Homozygous mutants of OPG show a severe decrease in bone density
    • Bucay N, Sarosi I, Dunstan CR, Morony S, Tarpley J, Capparelli C, Scully S, Tan HL, Xu W, Lacey DL, et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. of special interest Genes Dev. 12:1998;1260-1268 Targeted inactivation of the osteoprotegerin (OPG) gene in mice is described. Homozygous mutants of OPG show a severe decrease in bone density.
    • (1998) Genes Dev , vol.12 , pp. 1260-1268
    • Bucay, N.1    Sarosi, I.2    Dunstan, C.R.3    Morony, S.4    Tarpley, J.5    Capparelli, C.6    Scully, S.7    Tan, H.L.8    Xu, W.9    Lacey, D.L.10
  • 44
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • of outstanding interest. Identification of the osteoprotegerin ligand (OPGL) is reported here. OPGL is related to the TNF receptor family but can exists as a transmembrane or soluble form. OPGL activates osteoclast maturation in vitro and enhances bone resorption in vivo
    • Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Brugess T, Elliot R, Colombero A, Elliot G, Scully S, Hsu H, et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. of outstanding interest Cell. 93:1998;165-176 Identification of the osteoprotegerin ligand (OPGL) is reported here. OPGL is related to the TNF receptor family but can exists as a transmembrane or soluble form. OPGL activates osteoclast maturation in vitro and enhances bone resorption in vivo.
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3    Kelley, M.J.4    Dunstan, C.R.5    Brugess, T.6    Elliot, R.7    Colombero, A.8    Elliot, G.9    Scully, S.10    Hsu, H.11
  • 45
    • 0032584208 scopus 로고    scopus 로고
    • Osteoclast differentiation factor is a ligand for osteoprotegerin/osteclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    • of outstanding interest. This paper demonstrates purification and cloning of the osteoclast differentiation factor (ODF) gene. In vitro experiments show that ODF is the osteoprotegerin ligand and that it mediates osteoclast differentiation
    • Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. of outstanding interest Proc Natl Acad Sci USA. 95:1998;3597-35602 This paper demonstrates purification and cloning of the osteoclast differentiation factor (ODF) gene. In vitro experiments show that ODF is the osteoprotegerin ligand and that it mediates osteoclast differentiation.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3597-35602
    • Yasuda, H.1    Shima, N.2    Nakagawa, N.3    Yamaguchi, K.4    Kinosaki, M.5    Mochizuki, S.6    Tomoyasu, A.7    Yano, K.8    Goto, M.9    Murakami, A.10
  • 48
    • 0026486816 scopus 로고
    • Pleiotropic effects of a null mutation in the c-fos proto-oncogene
    • Johnson RS, Spiegelman BM, Papaioannou V. Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell. 71:1992;577-586.
    • (1992) Cell , vol.71 , pp. 577-586
    • Johnson, R.S.1    Spiegelman, B.M.2    Papaioannou, V.3
  • 49
    • 15444357762 scopus 로고    scopus 로고
    • Requirement for NF-kappa B in osteoclast and B-cell development
    • of special interest. Simultaneous targeted inactivation of the genes encoding the p50 and p52 subunits of NFκB is described. Doubly homozygous mutants present severe osteopetrosis due to an absence of osteoclasts. B cells are also absent
    • Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, Leonardi A, Tran T, Boyce BF, Siebenlist U. Requirement for NF-kappa B in osteoclast and B-cell development. of special interest Genes Dev. 11:1997;3482-3496 Simultaneous targeted inactivation of the genes encoding the p50 and p52 subunits of NFκB is described. Doubly homozygous mutants present severe osteopetrosis due to an absence of osteoclasts. B cells are also absent.
    • (1997) Genes Dev , vol.11 , pp. 3482-3496
    • Franzoso, G.1    Carlson, L.2    Xing, L.3    Poljak, L.4    Shores, E.W.5    Brown, K.D.6    Leonardi, A.7    Tran, T.8    Boyce, B.F.9    Siebenlist, U.10
  • 50
    • 0027204149 scopus 로고
    • Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein
    • Hodgkinson CA, Moore KJ, Nakayama A, Steingrimsson E, Copeland NG, Jenkins NA, Arnheiter H. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell. 74:1993;395-404.
    • (1993) Cell , vol.74 , pp. 395-404
    • Hodgkinson, C.A.1    Moore, K.J.2    Nakayama, A.3    Steingrimsson, E.4    Copeland, N.G.5    Jenkins, N.A.6    Arnheiter, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.