Comparison of the biochemical responses to human parathyroid hormone-(1-31)NH2 and hPTH-(1-34) in healthy humans

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 8, 1999, Pages 2739-2743

  Fraher, Laurence J ^a,d   Avram, R ^a   Watson, P H ^a   Hendy, G N ^b   Henderson, J E ^b   Chong, K L ^b   Goltzman, D ^b   Morley, P ^c   Willick, G E ^c   Whitfield, J F ^c   Hodsman, A B ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^d ST JOSEPH S HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; CALCITRIOL; CALCIUM ION; COLLAGEN TYPE 1; CREATININE; CYCLIC AMP; HORMONE DERIVATIVE; OXYGENASE; PARATHYROID HORMONE[1-31]; PARATHYROID HORMONE[1-34]; PHOSPHATE; SODIUM; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CALCIUM BLOOD LEVEL; COLLAGEN DEGRADATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; FEMALE; HORMONAL THERAPY; HUMAN; HUMAN EXPERIMENT; KIDNEY FUNCTION; MALE; NATRIURESIS; NORMAL HUMAN; OSTEOPOROSIS; PHOSPHATURIA; PRIORITY JOURNAL; TARGET ORGAN;

EID: 0033329305     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.8.2739     Document Type: Article

References (32)

1. Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: Differential effects of intermittent and continuous administration
2. Effects of continuous infusion of parathyroid hormone and parathyroid hormone-related peptide on rat bone in vivo: Comparative study by histomorphometry
3. Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone
4. Parathyroid hormone restores bone mass and enhances osteoblast insulin-like growth factor-I gene expression in ovariectomized rats
5. Anabolic effect of low doses of a fragment of human parathyroid hormone on the skeleton in postmenopausal osteoporosis
6. Preliminary trial of low doses of human parathyroid hormone 1-34 peptide in treatment of osteoporosis-477
7. Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: A multi centre trial
8. Parathyroid hormone for the prevention of bone loss induced by estrogen deficiency
9. Periodic courses of human 1-34 parathyroid peptide alternating with calcitriol paradoxically reduce bone remodelling in spinal osteoporosis
10. Increase of vertebral density by combination therapy with pulsatile 1-38 hPTH and sequential addition of calcitonin nasal spray in osteoporotic patients
11. Biochemical responses to sequential human parathyroid hormone (1-38) and calcitonin in osteoporotic patients. Bone Miner
12. Bone densitometric and histomorphometric responses to sequential human parathyroid hormone (1-38) and salmon calcitonin in osteoporotic patients
13. An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis
14. Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen width osteoporosis
15. Prevention of estrogen deficiency-related bone loss with human parathyroid hormone-(1-34): A randomized controlled trial
16. A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone vs. cyclical parathyroid hormone and sequential calcitonin to improve bone mass in post-menopausal women with osteoporosis
17. Parathyroid hormone: The clinical experience and prospects
18. Parathyroid hormone fragments may stimulate bone growth in ovariectomized rats by activating adenylyl cyclase
19. 2 (Ostabolin)
20. 2 to stimulate femoral trabecular bone growth in ovariectomized rats
21. Adenylyl cyclase activating agents: Parathyroid hormone and prostaglandins
22. The protein kinase-C activation domain of the parathyroid hormone
23. Further definition of the protein kinase-C activating domain of the parathyroid hormone
24. Solution structure and adenylyl cyclase stimulating activities of C-terminal truncated human parathyroid hormone analogues
25. Type I parathyroid (PTH)PTH-related peptide (PTHrP) receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH(1-34)
26. Comparison of the in vivo biochemical responses to exogenous parathyroid hormone (1-34) and parathyroid hormone-related peptide (1-34) in man
27. Comparison of the pharmacokinetics of parenteral parathyroid hormone (1-34) {PTH-(1-34)} and PTH-related peptide (1-34) in healthy young humans
28. Influence of the amino-terminus on in vitro and in vivo biological activity of synthetic parathyroid hormone-like peptides of malignancy
29. Constitutive expression of parathyroid hormone-related peptide (PTHrP) stimulates growth and inhibits differentiation of CFK2 chondrocytes
30. 2 in man
31. Bone responsiveness to parathyroid hormone in normal and osteoporotic postmenopausal women
32. Subcutaneous administration of the amino-terminal fragment of human parathyroid hormone-(1-34): Kinetics and biochemical responses in estrogenized osteoporotic patients