Type-1 parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH(1- 34)

Endocrinology

Volumn 139, Issue 10, 1998, Pages 4293-4299

  Takasu, Hisashi ^a   Bringhurst, F Richard ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE[1-34]; PHOSPHOLIPASE C; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVATION; NONHUMAN; OSTEOSARCOMA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0031764941     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.10.6261     Document Type: Article

References (37)

1. Usdin TB, Modi W, Bonner TI 1996 Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization. Genomics 37:140-141
2. Abou-Samra AB, Juppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts Jr JT, Kronenberg HM, Segre GV 1992 Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 89:2732-2736
3. Civitelli R, Reid IR, Westbrook S, Avioli LV, Hruska KA 1988 PTH elevates inositol polyphosphates and diacylglycerol in a ratosteoblast-like cell line. Am J Physiol 255:E660-E667
4. Civitelli R, Martin TJ, Fausto A, Gunsten SL, Hruska KA, Avioli LV 1989 Parathyroid hormone-related peptide transiently increases cytosolic calcium in osteoblast-like cells: comparison with parathyroid hormone. Endocrinology 125:1204-1210
5. Bringhurst FR, Juppner H, Guo J, Urena P, Potts Jr JT, Kronenberg HM 1993 Cloned, stably expressed parathyroid hormone (PTH)/PTH-related peptide receptors activate multiple messenger signals and biological responses in LLC-PK1 kidney cells. Endocrinology 132:2090-2098
6. Juppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski Jr LF, Hock J, Potts Jr JT, Kronenberg HM, Segre GV 1991 A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024-1026
7. Lee K, Deeds JD, Segre GV 1995 Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats. Endocrinology 136:453-463
8. Usdin TB, Bonner TI, Harta G, Mezey E 1996 Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat. Endocrinology 137:4285-4297
9. Fujimori A, Cheng SL, Avioli LV, Civitelli R 1991 Dissociation of second messenger activation by parathyroid hormone fragments in osteosarcoma cells. Endocrinology 128:3032-3039
10. Whitfield JF, Morley P 1995 Small bone-building fragments of parathyroid hormone: new therapeutic agents for osteoporosis. Trends Pharmacol Sci 16:382-386
11. Rixon RH, Whitfield JF, Gagnon L, Isaacs RJ, Maclean S, Chakravarthy B, Durkin JP, Neugebauer W, Ross V, Sung W, Willick G 1994 Parathyroid hormone fragments may stimulate bone growth in ovariectomized rats by activating adenylyl cyclase. J Bone Miner Res 9:1179-1189
12. Chakravarthy BR, Durkin JP, Rixon RH, Whitfield JF 1990 Parathyroid hormone fragment (3-34) stimulates protein kinase C (PKC) activity in rat osteosarcoma and murine T-lymphoma cells. Biochem Biophys Res Commun 171:1105-1110
13. Fujimori A, Cheng SL, Avioli LV, Civitelli R 1992 Structure-function relationship of parathyroid hormone: activation of phospholipase-C, protein kinase-A and -C in osteosarcoma cells. Endocrinology 130:29-36
14. Jouishomme H, Whitfield JF, Chakravarthy B, Durkin JP, Gagnon L, Isaacs RJ, Maclean S, Neugebauer W, Willick G, Rixon RH 1992 The protein kinase-C activation domain of the parathyroid hormone. Endocrinology 130:53-60
15. Jouishomme H, Whitfield JF, Gagnon L, Maclean S, Isaacs R, Chakravarthy B, Durkin J, Neugebauer W, Willick G, Rixon RH 1994 Further definition of the protein kinase C activation domain of the parathyroid hormone. J Bone Miner Res 9:943-949
16. Whitfield JF, Morley P, Willick GE, Ross V, Barbier JR, Isaacs RJ, Ohannessian-Barry L 1996 Stimulation of the growth of femoral trabecular bone in ovariectomized rats by the novel parathyroid hormone fragment, hPTH-(1-31)NH2 (Ostabolin). Calcif Tissue Int 58:81-87
17. Armamento-Villareal R, Ziambaras K, Abbasi-Jarhomi H, Dimarogonas A, Halstead L, Fausto A, Avioli LV, Civitelli R 1997 An intact N terminus is required for the anabolic action of parathyroid hormone on adult female rats. J Bone Miner Res 12:384-392
18. Juppner H, Schipani E, Bringhurst FR, McClure I, Keutmann HT, Potts JT 1994 The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34). Endocrinology 134:879-884
19. Gardella TJ, Juppner H, Wilson AK, Keutmann HT, Abou-Samra AB, Segre GV 1994 Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor. Endocrinology 135:1186-1194
20. Takasu H, Guo J, Bringhurst FR 1997 Human and rat PTH/PTHrP receptors display different signal selectivity for hPTH(1-31) amd hPTH(1-30) in stably transfected LLC-PK1 cells. J Bone Miner Res [Suppl 1]12:S444 (Abstract)
21. Guo J, Iida-Klein A, Huang X, Abou-Samra AB, Segre GV, Bringhurst FR 1995 Parathyroid hormone (PTH)/PTH-related peptide receptor density modulates activation of phospholipase C and phosphate transport by PTH in LLC-PK1 cells. Endocrinology 136:3884-3891
22. Iida-Klein A, Guo J, Xie LY, Juppner H, Potts Jr JT, Kronenberg HM, Bringhurst FR, Abou-Samra AB, Segre GV 1995 Truncation of the carboxyl-terminal region of the rat parathyroid hormone (PTH)/PTH-related peptide receptor enhances PTH stimulation of adenylyl cyclase but not phospholipase C. J Biol Chem 270:8458-8465
23. Neugebauer W, Barbier JR, Sung WL, Whitfield JF, Willick GE 1995 Solution structure and adenylyl cyclase stimulating activities of C-terminal truncated human parathyroid hormone analogues. Biochemistry 34:8835-8842
24. Miller B, Burns C, Travis J, Beale L, Sweeney D, Schlegel B, Harden R, Jariwala N, Burke K 1997 Anabolic potency of PTH peptides correlates with cAMP stimulatory activity. J Bone Miner Res [Suppl 1]12:S320 (Abstract)
25. Friedman PA, Morley P, Whitfield JF, Willick G, Gesek FA 1997 Structure-activity analysis of amino-terminal PTH analogues reveals discrete signaling effects on renal distal and proximal convoluted tuble cells. J Bone Miner Res [Suppl 1]12:S317 (Abstract)
26. Mitchell J, Goltzman D 1990 Mechanisms of homologous and heterologous regulation of parathyroid hormone receptors in the rat osteosarcoma cell line UMR-106. Endocrinology 126:2650-2660
27. Inomata N, Akiyama M, Kubota N, Juppner H 1995 Characterization of a novel parathyroid hormone (PTH) receptor with specificity for the carboxyl-terminal region of PTH-(1-84). Endocrinology 136:4732-4740
28. Murray TM, Rao LG, Muzaffar SA, Ly H 1989 Human parathyroid hormone carboxylterminal peptide (53-84) stimulates alkaline phosphatase activity in dexamethasone-treated rat osteosarcoma cells in vitro. Endocrinology 124:1097-1099
29. Murray TM, Rao LG, Muzaffar SA 1991 Dexamethasone-treated ROS 17/2.8 rat osteosarcoma cells are responsive to human carboxylterminal parathyroid hormone peptide hPTH(53-84): stimulation of alkaline phosphatase. Calcif Tissue Int 49:120-123
30. Nakamoto C, Baba H, Fukase M, Nakajima K, Kimura T, Sakakibara S, Fujita T, Chihara K 1993 Individual and combined effects of intact PTH, amino-terminal, and a series of truncated carboxyl-terminal PTH fragments on alkaline phosphatase activity in dexamethasone-treated rat osteoblastic osteosarcoma cells, ROS 17/2.8. Acta Endocrinol 128:367-372
31. Seitz PK, Nickols GA, Nickols MA, McPherson MB, Cooper CW 1990 Radioiodinated rat parathyroid hormone-(1-34) binds to its receptor on rat osteosarcoma cells in a manner consistent with two classes of binding sites. J Bone Miner Res 5:353-359
32. Rouleau MF, Mitchell J, Goltzman D 1990 Characterization of the major parathyroid hormone target cell in the endosteal metaphysis of rat long bones. J Bone Miner Res 5:1043-1053
33. Bos MP, van dMJM, Feyen JH, Herrmann-Erlee MP 1996 Expression of the parathyroid hormone receptor and correlation with other osteoblastic parameters in fetal rat osteoblasts. Calcif Tissue Int 58:95-100
34. Tatrai A, Lee SK, Stern PH 1994 U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells. Biochim Biophys Acta 1224:575-582
35. McCauley L, Koh A, Beecher C, Cui Y, Rosol T, Francheschi R 1996 PTH/ PTHrP receptor is temporally regulated during osteoblast differentiation and is associated with collagen synthesis. J Cell Biochem 61:638-647
36. Nussbaum SR, Rosenblatt M, Potts Jr JT 1980 Parathyroid hormone-renal receptor interactions. J Biol Chem 255:10183-10187
37. Gardella TJ, Wilson AK, Keutmann HT, Oberstein R, Potts Jr JT, Kronenberg M, Nussbaum SR 1993 Analysis of parathyroid hormone's principal receptor-binding region by site-directed mutagenesis and analog design. Endocrinology 132:2024-2030