C/EBPε directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters

Blood

Volumn 93, Issue 10, 1999, Pages 3327-3337

  Verbeek, Walter ^b   Gombart, Adrian F ^b   Chumakov, Alexey M ^b   Müller, Carsten ^b   Friedman, Alan D ^b   Koeffler, H Phillip ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN EPSILON; DNA; ISOPROTEIN; LEUKOCYTE ELASTASE; UNCLASSIFIED DRUG; CCAAT ENHANCER BINDING PROTEIN; CEBPE PROTEIN, HUMAN; CEBPE PROTEIN, MOUSE; DNA BINDING PROTEIN; HYBRID PROTEIN; ONCOPROTEIN; PROTEIN C MYB; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA TRANSFECTION; GENE INDUCTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOLECULAR DYNAMICS; MYELOPOIESIS; NONHUMAN; ONCOGENE C MYB; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; CELL NUCLEUS; CELL STRAIN COS1; CELL STRAIN U937; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HEMATOPOIESIS; METABOLISM; MOLECULAR CLONING; MOUSE; ONCOGENE; PROTEIN SYNTHESIS; REPORTER GENE;

ANIMALS; BINDING SITES; CCAAT-ENHANCER-BINDING PROTEINS; CELL NUCLEUS; CLONING, MOLECULAR; COS CELLS; DNA-BINDING PROTEINS; GENES, REPORTER; HEMATOPOIESIS; HUMANS; JURKAT CELLS; LEUKOCYTE ELASTASE; MICE; ONCOGENES; PROMOTER REGIONS (GENETICS); PROTEIN BIOSYNTHESIS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYB; RECOMBINANT FUSION PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; U937 CELLS;

EID: 0033561795     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.10.3327     Document Type: Article

References (46)

1. Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG: A novel human CCAAT/enhancer binding protein gene, C/EBPε is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor α/δ locus. Genomics 35:30, 1996
2. Chumakov AM, Grillier I, Chumakowa E, Chih D, Slater J, Koeffler HP: Cloning of the novel human myeloid-cell-specific C/EBPε transcription factor. Mol Cell Biol 17:1375, 1997
3. Landschultz WH, Johnson PF, Adashi EY, Graves BJ, McKnight SL: Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev 2: 786, 1988
4. Akira S, Isshiki H, Suguita T, Tanaba S, Kinishita S, Nishio Y, Hirano T, Kishimoto T: A nuclear factor for IL6 expression is a member of a C/EBP family. EMBO J 9:1897, 1990
5. Cao Z, Umek RM, McKnight SL: Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev 5:1538, 1991
6. Chang CJ, Chen TT, Lei HY, Chen DS, Lee SC: Molecular cloning of transcription factor, AGF/C/EBP that belongs to members of the C/EBP family. Mol Cell Biol 10:6642, 1990
7. Descombes P, Schibler U: A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67:569, 1991
8. Katz S, Kowentz-Leutz E, Muller C, Meese K, Ness SA, Leutz A: The NF-M transcription factor is related to C/EBPβ and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells. EMBO J 12:1321, 1993
9. Poli V, Mancini FP, Cortese R: IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell 63:643, 1990
10. Roman C, Platero JS, Shuman JD, Calame K: Ig/EBP-1: A ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP. Genes Dev 4:1404, 1990
11. Kinoshita S, Akira S, Kishimoto T: A member of the C/EBP family, NF-IL6β, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad Sci USA 89:1473, 1992
12. Williams PW, Cantwell CA, Johnson PF: A family of C/EBP related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev 5:1553, 1991
13. Ron D, Habener JF: CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant negative inhibitor of gene transcription. Genes Dev 6:439, 1992
14. Osada S, Yamamoto H, Nishihara T, Imagawa M: DNA binding specificity of the CCAAT/enhancer-binding protein transcription factor family. J Biol Chem 271:3891, 1996
15. Morosetti R, Park DJ, Chumakow AM, Grillier I, Shiohara M, Gombart AF, Nakamaki T, Weinberg K, Koeffler HP: A novel, myeloid transcription factor, C/EBPε is upregulated during granulocytic, but not monocytic differentiation. Blood 90:2591, 1997
16. Yamanaka R, Kim G-D, Radomska HS, Lekstrom-Himes J, Smith LT, Antonson P, Tenen D, Xanthopoulos K: CCAAT/enhancer binding protein ε is preferentelly upregulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing. Proc Natl Acad Sci USA 94:6462, 1997
17. Ossipow V, Desombles P, Schibler U: CCAAT/enhancer binding protein mRNA is translated into multiple proteins with different transcription activation potentials. Proc Natl Acad Sci USA 90:8219, 1993
18. Williamson E, Xu HN, Gombart AF, Verbeek W, Chumakov AM, Friedman AD, Koeffler HP: Identification of transcriptional activation and repression domains in human C/EBPε. J Biol Chem 273:14796, 1998
19. Smith L, Hohaus S, Gonzalez DA, Dziennis S, Tenen D: PU.1 (Spi-1) and C/EBPα regulate the granulocyte colony stimulating factor promoter in myeloid cells. Blood 88:1234, 1996
20. Hohaus S, Petrovick MS, Voso MT, Sun Z, Zhang DE, Tenen DG: PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony stimulating factor receptor alpha gene. Mol Cell Biol 10:5830, 1995
21. Zhang DE, Hetherington CJ Meyers S, Rhoades KL, Larson CJ, Chen HM, Hiebert SW, Tenen DG: CCAAT enhancer binding protein (C/EBP) and AML-1 (CBF alpha 2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol 16:1231, 1996
22. Sturrock A, Franklin KF, Hoidal JR: Human proteinase 3 expression is regulated by PU.1 in conjunction with a cytidine rich element. J Biol Chem 271:32392, 1996
23. Nuchprayoon I, Meyer S, Scott LM, Suzow J, Hiebert S, Friedman AD: PEBP2 beta/CBF, the murine homolog of the myeloid AML-1 and PEBP2beta/CBF beta protooncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes, in immature myeloid cells. Mol Cell Biol 14:5558, 1994
24. Austin GE, Zhao WG, Zhang W, Austin ED, Findley HW, Murtagh JJ Jr: Identification and characterisation of the human myeloperoxidase promoter. Leukemia 9:848, 1995
25. Oelegeschlaeger M, Nuchprayoon I, Luescher B, Friedman AD: C/EBP, c-myb and PU.1 cooperate to regulate the neutrophil elastase promoter. Mol Cell Biol 16:4717, 1996
26. Godambe SA, Chaplin DD, Takova T, Bellone CJ: Upstream NFIL6-like site located within a DNAse 1 hypersensitivity region mediates LPS-induced transcription of murine interleukin 1 beta gene. J Immunol 153:143, 1994
27. Pope RM, Leutz A, Ness SA: C/EBP beta regulation of the tumor necrosis factor alpha gene. J Clin Invest 94:1449, 1994
28. Williams SC, Du Y, Schwartz RC, Weiler SR Ortiz M, Keller JR, Johnson PF: C/EBPε is a myeloid specific activator of cytokine, chemokine, and macrophage-colony-stimulating factor receptor genes. J Biol Chem 273:13493, 1998
29. Ness SA, Marknell A, Graf T: The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene. Cell 59:1115, 1989
30. Ness SA, Kowentz-Leutz E, Casini T, Graf T, Leutz A: Myb and NFM: Combinatorial activators of myeloid genes in heterologous cell types. Genes Dev 7:749, 1993
31. Oelgeschlaeger M, Jahnknecht R, Krieg J, Schreek S, Luescher B: Interaction of the coactivator CBP with myb proteins: Effects on myb-specific transactivation and on the cooperativity with NFM. EMBO J 15:2771, 1996
32. Mink S, Kerber U, Klempnauer KH: Interaction of C/EBPβ and v-myb is required for synergistic activation of the mim-1 gene. Mol Cell Biol 16:1316, 1996
33. Mink S, Haenig B, Klempnauer KH: Interaction and functional cooperation of p300 and C/EBPβ. Mol Cell Biol 17:6609, 1997
34. Ida K, Kitabayashi I, Taki T, Taniwaki M, Noro K, Yamamoto M, Ohki M, Hayshi Y: Adenoviaral E1A-associated protein is involved in acute myeloid leukemia with t(11;22) (q23;q13) Blood 90:4699, 1997
35. Giles RH, Dauwerse JG, Higgins C, Petrij F, Wessels JW, Beverstock GC, Dohner H, Jotterland-Belomo M, Falkenburg JH, Slater RM, van Ommen GJ, Hagemeijer A, van der Reijden BA, Breuning MH: Detection of CBP rearrangements in acute myeloid leukemia with t(8; 16) Leukemia 11:2087, 1997
36. Westendorf JJ, Yamamoto CM, Lenny N, Downing JR Selsted ME, Hiebert SW: The t(8;21) fusion product AML-1-Eto associates with C/EBPα, inhibits C/EBP alpha-dependent transcription, and blocks granulocytic differentiation. Mol Cell Biol 18:322, 1998
37. Zhang DE, Zhang P, Wang N-D, Hetherington CJ, Darlington GJ, Tenen D: Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc Natl Acad Sci USA 94:569, 1997
38. Tanaka T, Akira S, Yoshida K, Umemoto M, Yoneda Y, Shirafuji N, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T: Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80:353, 1995
39. Yamanaka R, Barlow C, Lekstrom-Himes, Castilla LH, Liu PP, Eckhaus M, Decker T, Wynshaw-Boris A, Xanthopoulos K: Impaired granulopoiesis, myelodysplasia and early lethality in CCAAT/enhancer binding protein ε-deficient mice. Proc Natl Acad Sci USA 94:131187, 1997
40. Lunblad JR, Kwok RPS, Lawrence ME, Hurter ML, Goodman RH: Adenoviral E1A-associated protein 300 as a functional homologue of the transcriptional coactivator CBP. Nature 374:85, 1995
41. Aziz N, Wu J, Dubendorff JW, Lipsick JS, Sturgill TW, Bender TP: c-myb and v-myb are differentially phosphorylated by p42mapk in vitro. Oncogene 8:2259, 1993
42. Aziz N, Miglarese MR, Hendrickson RC, Shabanowitz J, Sturgill TW, Hunt DF, Bender TP: Modulation of c-myb induced transcription activation by a phosporylation site near the negative regulatory domain. Proc Natl Acad Sci USA 92:6429, 1995
43. Chih DY, Chumakov AM, Park DJ, Silla AG, Koeffler HP: Modulation of mRNA expression of a novel human myeloid selective CCAAT/enhancer binding protein gene (C/EBP epsilon). Blood 90: 2987, 1997
44. Introna M, Golay J, Frampton J, Nakano T, Ness SA, Graf T: Mutations in v-myb alter the differentiation of myelomonocytic cells transformed by the oncogene. Cell 63:1287, 1990
45. Nuchprayoon I, Simkevich CP, Luo M, Friedman AD, Rosmarin AG: GABP cooperates with c-myb and C/EBP to activate the neutrophil elastase promoter. Blood 89:4546, 1997
46. Graf T: Myb a transcriptional activator linking proliferation and differentiation in hematopoietic cells. Curr Opin Genet Dev 2:249, 1992