Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases

Molecular and Cellular Biology

Volumn 17, Issue 5, 1997, Pages 2413-2424

  Lai, Fang ^a   Chen, Chun Xia ^a   Carter, Kenneth C ^b   Nishikura, Kazuko ^a  

^a WISTAR INSTITUTE   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; DEAMINASE; DOUBLE STRANDED RNA; GLUTAMATE RECEPTOR; INOSINE; ION CHANNEL; ISOENZYME; RECEPTOR SUBUNIT; RECOMBINANT PROTEIN;

ALTERNATIVE RNA SPLICING; ARTICLE; ENZYME ACTIVITY; ENZYME SPECIFICITY; MOLECULAR CLONING; PRIORITY JOURNAL; RNA EDITING; SEQUENCE HOMOLOGY;

EID: 0031003879     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.5.2413     Document Type: Article

References (51)

1. Adams, M. D., A. R. Kerlavage, R. D. Fleischmann, R. A. Fuldner, C. J. Bult, N. H. Lee, E. F. Kirkness, K. G. Weinstock, J. D. Gocayne, O. White, G. Sutton, J. A. Blake, R. C. Brandon, M.-W. Chiu, R. A. Clayton, R. T. Cline, FitzHugh, J. L. Fritchman, N. S. M. Geoghagen, A. Glodek, C. L. Gnehm, M. C. Hanna, E. Hedblom, P. S. Hinkle, Jr., J. M. Kelley, K. M. Klimek, J. C. Kelly, L.-I. Liu, S. M. Marmaros, J. M. Merrick, R. F. Moreno-Palanques, L. A. McDonald, D. T. Nguyen, S. M. Pellegrino, C. A. Phillips, S. E. Ryder, J. L. Scott, D. M. Saudek, R. Shirley, K. V. Small, T. A. Spriggs, T. R. Utterback, J. F. Weidman, Y. Li, R. Barthlow, D. P. Bednarik, L. Cao, M. A. Cepeda, T. A. Coleman, E.-J. Collins, D. Dimke, P. Feng, A. Ferrie, C. Fischer, G. A. Hastings, W.-W. He, J.-S. Hu, K. A. Huddleston, J. M. Greene, J. Gruber, P. Hudson, A. Kim, D. L. Kozak, C. Kunsch, H. Ji, H. Li, P. S. Meissner, H. Olsen, L. Raymond, Y.-F. Wei, J. Wing, C. Xu, G.-L. Yu, S. M. Ruben, P. J. Dillon, M. R. Fannon, C. A. Rosen, W. A. Haseltine, C. Fields, C. M. Fraser, and J. C. Venter. 1995. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Nature (London) 377(Suppl.):3-174.
2. Altschul, S. F., W. Gish, W. Miller, E. W. Myer, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
3. Bass, B. L. 1995. An I for editing. Curr. Biol. 5:598-600.
4. Benne, R. 1996. The long and short of it. Nature (London) 380:391-392.
5. Berk, A. J., and P. A. Sharp. 1978. Spliced early mRNAs of simian virus 40. Proc. Natl. Acad. Sci. USA 75:1274-1278.
6. Bernard, A., and M. Khrestchatisky. 1994. Assessing the extent of RNA editing in the TMII regions of GluR5 and GluR6 kainate receptors during rat brain development. J. Neurochem. 62:2057-2060.
7. Burnashev, N., H. Monyer, P. H. Seeburg, and B. Sakmann. 1992. Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron 8:189-198.
8. Caras, I. W., M. A. Davitz, L. Rhee, G. Weddell, D. W. Martin, Jr., and V. Nussenzweig. 1987. Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins. Nature (London) 325:545-549.
9. Chan, L., and K. Nishikura. Mammalian RNA editing. In D. Morris and J. B. Harford (ed.), Posttranscriptional gene regulation, modern cell biology, in press. Wiley-Liss Books, New York, N.Y.
10. Cheng, J.-F., V. Boyartchuk, and Y. Zhu. 1994. Isolation and mapping of human chromosome 21 cDNA: progress in constructing a chromosome 21 expression map. Genomics 23:75-84.
11. Dabiri, G. A., F. Lai, R. A. Drakas, and K. Nishikura. 1996. Editing of the GluR-B ion channel RNA in vitro by recombinant double-stranded RNA adenosine deaminase. EMBO J. 15:34-45.
12. Devereux, J., P. Haeberli, and O. Smithies. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12:387-395.
13. Egebjerg, J., V. Kakekov, and S. F. Heinemann. 1994. Intron sequence directs RNA editing of the glutamate receptor subunit GluR2 coding sequence. Proc. Natl. Acad. Sci. USA 91:10270-10274.
14. Görlich, D., and I. W. Mattaj. 1996. Nucleocytoplasmic transport. Science 271:1513-1518.
15. Herb, A., M. Higuchi, R. Sprengel, and P. H. Seeburg. 1996. Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences. Proc. Natl. Acad. Sci. USA 93:1875-1880.
16. Herbert, A., Y.-G. Kim, J. Alfken, K. Nishikura, and A. Rich. A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase. Proc. Natl. Acad. Sci. USA, in press.
17. Higuchi, M., F. N. Single, M. Köhler, B. Sommer, R. Sprengel, and P. H. Seeburg. 1993. RNA editing of AMPA receptor subunit GluR-B: a base-paired intron exon structure determines position and efficiency. Cell 75: 1361-1370.
18. Hopp, T. P., K. S. Prickett, V. Prive, R. T. Libby, C. March, P. Ceretti, D. L. Urdal, and P. J. Conlon. 1988. A short polypeptide marker sequence useful for recombinant protein identification and purification. Biotechnology 6:1205-1210.
19. Kao, P. N., L. Chen, G. Brock, J. Ng, J. Kenny, A. J. Smith, and B. Corthesy. 1994. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. J. Biol. Chem. 269:20691-20699.
20. Kim, U., T. L. Garner, T. Sanford, D. Speicher, J. M. Murray, and K. Nishikura. 1994. Purification and characterization of double-stranded RNA adenosine deaminase from bovine nuclear extracts. J. Biol. Chem. 269: 13480-13489.
21. Kim, U., Y. Wang, T. Sanford, Y. Zeng, and K. Nishikura. 1994. Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing. Proc. Natl. Acad. Sci. USA 91:11457-11461.
22. 2+ permeability in both TM1 and TM2 of high-affinity kainate receptor channels: diversity by RNA editing. Neuron 10:491-500.
23. Köhler, M., H.-C. Kornaut, and P. H. Seeburg. 1994. The organization of the gene for the functionally dominant α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor subunit GluR-B. J. Biol. Chem. 269:17367-17370.
24. Korenberg, J., X.-N. Chen, R. Schipper, Z. Sun, R. Gonsky, S. Gerwehr, N. Carpenter, C. Daumer, P. Dignan, C. Disteche, J. M. Graham, Jr., L. Hudgins, B. McGillivray, K. Miyazaki, N. Ogasawara, J. P. Park, R. Pagon, S. Pueschel, G. Sack, B. Say, S. Schuffenhauer, S. Soukup, and T. Yamanaka. 1994. Down syndrome phenotypes: the consequences of chromosomal imbalance. Proc. Natl. Acad. Sci. USA 91:4997-5001.
25. Kozak, M. 1989. The scanning model for translation: an update. J. Cell Biol. 108:229-241.
26. Lai, F., R. Drakas, and K. Nishikura. 1995. Mutagenic analysis of double-stranded RNA adenosine deaminase, a candidate enzyme for RNA editing of glutamate-gated ion channel transcripts. J. Biol. Chem. 270:17098-17105.
27. Lai, F., C.-X. Chen, V. M.-Y. Lee, and K. Nishikura. Dramatic increase of the RNA editing mechanism for glutamate receptor subunits during terminal differentiation of clonal human neurons. J. Neurochem., in press.
28. Lomeli, H., J. Mosbacher, T. Melcher, T. Höger, J. R. P. Geiger, T. Kuner, H. Monyer, M. Higuchi, A. Bach, and P. H. Seeburg. 1994. Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science 226:1709-1713.
29. Maas, S., T. Melcher, A. Herb, P. H. Seeburg, W. Keller, S. Krause, M. Higuchi, and M. A. O'Connell. 1996. Structural requirements for RNA editing in glutamate receptor pre-mRNAs by recombinant double-stranded RNA adenosine deaminase. J. Biol. Chem. 271:12221-12226.
30. Makalowski, W., G. A. Mitchell, and D. Labuda. 1994. Alu sequences in the coding regions of mRNA: a source of protein variability. Trends Genet. 10:188-193.
31. Melcher, T., S. Maas, A. Herb, R. Sprengel, P. H. Seeburg, and M. Higuchi. 1996. A mammalian RNA editing enzyme. Nature (London) 379:460-464.
32. Melcher, T., S. Maas, M. Higuchi, W. Keller, and P. H. Seeburg. 1995. Editing of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR-B pre-mRNA in vitro reveals site-selective adenosine to inosine conversion. J. Biol. Chem. 270:100-120.
33. Nutt, S. L., and R. K. Kamboj. 1994. Differential RNA editing efficiency of AMPA receptor subunit GluR-2 in human brain. NeuroReport 5:1679-1683.
34. O'Connell, M. A., S. Krause, M. Higuchi, J. J. Hsuan, N. Totty, A. Jenny, and W. Keller. 1995. Cloning of cDNAs encoding mammalian double-stranded RNA-specific adenosine deaminase. Mol. Cell. Biol. 15:1389-1397.
35. O'Reilly, D. R., L. K. Miller, and V. A. Lucklow. 1992. Baculovirus expression vectors. CRC Press, Inc., Boca Raton, Fla.
36. Paschen, W., and W. Djuricic. 1995. Regional differences in the extent of RNA editing of the glutamate receptor subunits GluR2 and GluR6 in rat brain. J. Neurosci. Methods 56:21-29.
37. Patterson, J. B., and C. E. Samuel. 1995. Expression and regulation by Interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase. Mol. Cell. Biol. 15:5376-5388.
38. Proudfoot, N. J., and G. G. Brownlee. 1976. 3′ non-coding region sequences in eukaryotic mRNA. Nature (London) 263:211-214.
39. Puchalski, R. B., J.-C. Louis, N. Brose, S. F. Traynelis, J. Egebjerg, V. Kukekov, R. J. Wenthold, S. W. Rogers, F. Lin, T. Moran, J. H. Morrison, and S. F. Heinemann. 1994. Selective RNA editing and subunit assembly of native glutamate receptors. Neuron 13:131-147.
40. Ruano, D., B. Lamholez, J. Rossier, A. V. Paternain, and J. Lerma. 1995. Kainate receptor subunits expressed in single cultured hippocampal neurons: molecular and function variants by RNA editing. Neuron 14:1009-1017.
41. Rueter, S. M., C. M. Burns, S. A. Coode, P. Mookherjee, and R. B. Emeson. 1995. Glutamate receptor RNA editing in vitro by enzymatic conversion of adenosine to inosine. Science 267:1491-1494.
42. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
43. Schumacher, J. M., K. Lee, S. Edelhoff, and R. E. Braun. 1995. Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules. J. Cell Biol. 129:1023-1032.
44. Scott, J. 1995. A place in the world for RNA editing. Cell 81:833-836.
45. Seeburg, P. H. 1996. The role of RNA editing in controlling glutamate receptor channel properties. J. Neurochem. 66:1-5.
46. Sommer, B., M. Köhler, R. Sprengel, and P. H. Seeburg. 1991. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 67:11-19.
47. St. Johnson, D., N. H. Brown, J. G. Gall, and M. Jantsch. 1992. A conserved double-stranded RNA-binding domain. Proc. Natl. Acad. Sci. USA 89:10979-10983.
48. Verdoorn, T. A., N. Burmashev, H. Monyer, P. H. Seeburg, and B. Sakmann. 1991. Structural determinants of ion flow through recombinant glutamate receptor channels. Science 252:1715-1718.
49. Wang, Y., Y. Zeng, J. M. Murray, and K. Nishikura. 1995. Genomic organization and chromosomal location of the human dsRNA adenosine deaminase gene: the enzyme for glutamate-activated ion channel RNA editing. J. Mol. Biol. 254:184-195.
50. Weier, H.-U. G., C. X. George, K. M. Greulich, and C. E. Samuel. 1995. The interferon-inducible, double-stranded RNA-specific adenosine deaminase gene (DSRAD) maps to human chromosome 1q21.1-21.2. Genomics 30: 372-375.
51. Yang, J.-H., P. Sklar, R. Axel, and T. Maniatis. 1995. Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adeosine. Nature (London) 374:77-81.