Lack of triglyceride-lowering properties of fish oil in apolipoprotein E - Deficient mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 21, Issue 3, 2001, Pages 401-406

  Asset, G ^a,b   Bauge E ^a,b   Fruchart, J C ^a,b   Dallongeville, Jean ^a,b  

^a INSERM   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Apolipoprotein E; Atherosclerosis; Diet; Fish oil; Lipoprotein; Lipoprotein lipase; Nutrition; Triglycerides; VLDL

Indexed keywords

CHOLESTEROL; COCONUT OIL; FISH OIL; LIPOPROTEIN LIPASE; SUNFLOWER OIL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FATTY ACID SYNTHESIS; HYPERLIPOPROTEINEMIA TYPE 3; LIPOLYSIS; MOUSE; NONHUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0035092638     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.21.3.401     Document Type: Article

References (29)

1. n-3 fatty acids and serum lipoproteins: Human studies
2. n-3 fatty acids and serum lipoproteins: Animal studies
3. Eicosapentaenoic acid inhibits the secretion of triacylglycerol and of apoprotein B and the binding of LDL in HepG2 cells
4. Reduced triglyceride formation from long-chain polyenoic fatty acids in rat hepatocytes
5. Administration of n-3 fatty acids in the diets of rats or directly to hepatocyte cultures results in different effects on hepatocellular apoB metabolism and secretion
6. Fish oil fatty acids impair VLDL assembly and/or secretion by cultured rat hepatocytes
7. Fish oil supplementation reduces beta-very low density lipoprotein in type III dysbetalipoproteinemia
8. Apolipoprotein E and the apolipoprotein E-deficient mouse
9. Sequential ultracentrifugation micromethod for separation of serum lipoproteins and assays of lipids, apolipoproteins, and lipoprotein particles
10. Method to measure apolipoprotein B-48 and B-100 secretion rates in an individual mouse: Evidence for a very rapid turnover of VLDL and preferential removal of B-48- relative to B- 100-containing lipoproteins
11. Triglyceride metabolism in heterozygote of Watanabe heritable hyperlipidemic rabbit
12. Regulation of gene expression by dietary fat
13. Effects of dietary fish oil on plasma high density lipoprotein: Electron spin resonance and fluorescence polarization studies of lipid ordering and dynamics
14. Remnant lipoprotein metabolism: Key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E
15. Changes in fatty acid metabolism in rat hepatocytes in response to dietary n-3 fatty acids are associated with changes in the intracellular metabolism and secretion of apolipoprotein B-48
16. The adaptive effects of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver
17. Quantification in vivo of the effects of different types of dietary fat on the loci of control involved in hepatic triacylglycerol secretion
18. The hypotriglyceridemic effect of eicosapentaenoic acid in rats is reflected in increased mitochondrial fatty acid oxidation followed by diminished lipogenesis
19. Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E-deficient mouse hepatocytes
20. Influence of n-3 fatty acid supplementation on the endogenous activities of plasma lipases
21. Postheparin lipolytic activity and plasma lipoprotein response to omega-3 polyunsaturated fatty acids in patients with primary hypertriglyceridemia
22. Lipoprotein lipase synthesis and secretion: Effects of concentration and type of fatty acids in adipocyte cell culture
23. Triglyceride hydrolysis of soy oil vs fish oil emulsions
24. Hydrolysis of chylomicron polyenoic fatty acid esters with lipoprotein lipase and hepatic lipase
25. The effects of dietary fish oil on hepatic high density and low density lipoprotein receptor activities in the rat
26. Lipoprotein lipases, lipoprotein density gradient profile and LDL receptor activity in miniature pigs fed fish oil and corn oil
27. Low density lipoprotein from humans supplemented with n-3 fatty acids depresses both LDL receptor activity and LDLr mRNA abundance in HepG2 cells
28. Dietary fish oil modification of cynomolgus monkey low density lipoproteins results in decreased binding and cholesteryl ester accumulation by cultured fibroblasts
29. Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants: A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both