C2-ceramide attenuates phenylephrine-induced vasoconstriction and elevation in [Ca2+](i) in rat aortic smooth muscle

Lipids

Volumn 34, Issue 7, 1999, Pages 689-695

  Zheng, Tao ^a   Li, Wenyan ^a   Wang, Jun ^b   Altura, Bella T ^a,b   Altura, Burton M ^a,b  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b SUNY Downstate Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; BISINDOLYLMALEIMIDE; CALCIUM ION; CERAMIDE; INDOMETACIN; N(G) METHYLARGININE; PHENYLEPHRINE; PROTEIN KINASE C INHIBITOR; STAUROSPORINE; CALCIUM; ENZYME INHIBITOR; NITRIC OXIDE; PROTEIN KINASE C;

ANIMAL TISSUE; AORTA MEDIA; ARTERY TONE; ARTERY WALL; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; MALE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASCULAR RING; VASOCONSTRICTION; VASODILATATION; ANIMAL; AORTA; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; VASCULAR SMOOTH MUSCLE; WISTAR RAT;

ANIMALIA;

ANIMALS; AORTA; CALCIUM; CERAMIDES; ENZYME INHIBITORS; INDOMETHACIN; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; PHENYLEPHRINE; PROTEIN KINASE C; RATS; RATS, WISTAR; VASOCONSTRICTION;

EID: 0032587470     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11745-999-0414-4     Document Type: Article

References (27)

1. Ballou, L.R. (1992) Sphingolipids and Cell Function, Immunol. Today 13, 339-341.
2. Hannun, Y.A. (1996) Functions of Ceramide in Coordinating Cellular Responses to Stress, Science 274, 1855-1859.
3. Hannun, Y.A. (1994) The Sphingomyelin Cycle and the Second Messenger Function of Ceramide, J. Biol. Chem. 269, 3125-3128.
4. Mathias, S., and Kolesnick, R. (1993) Ceramide: A Novel Second Messenger, Adv. Lipid Res. 25, 65-90.
5. Hannun, Y.A., and Bell, R.M. (1993) The Sphingomyelin Cycle: A Prototypic Sphingolipid Signaling Pathway, Adv. Lipid Res. 25, 27-40.
6. Kolesnick, R. (1994) Signal Transduction Through the Sphingomyelin Pathway, Mol. Chem. Neuropathol. 21, 287-297.
7. Altura, B.M., and Altura, B.T. (1995) Magnesium and Cardiovascular Biology: An Important Link Between Cardiovascular Risk Factors and Atherogenesis, Cell Mol. Biol. Res. 41, 347-360.
8. Schissel, S.L., Hardman, J.T., Rapp, J.H., Graham, G., Williams, K.J., and Tabas, I. (1996) Rabbit Aorta and Human Atherosclerotic Lesions Hydrolyze the Sphingomyelin of Retained Low-Density Lipoprotein. Proposed Role for Arterial-Wall Sphingomyelinase in Subendothelial Retension and Aggregation of Atherogenic Lipopoteins, J. Clin. Invest. 98, 1455-1464.
9. Exton, J.H. (1985) Mechanisms Involved in α-Adrenergic Phenomena, Am. J. Physiol. 248, E634-E647.
10. Altura, B.M., and Altura, B.T. (1974) Contractile Actions of Antihistamines on Isolated Arterial Smooth Muscle, J. Pharmacol. Exp. Ther. 191, 262-268.
11. +, Br. J. Pharmacol. 105, 305-310.
12. Zhang, A., Cheng, T.P.O., and Altura, B.M. (1992) Ethanol Decreases Cytosolic-Free Calcium Ions in Vascular Smooth Muscle Cells as Assessed by Digtial Image Analysis, Alcoholism Clin. Exp. Res. 16, 55-57.
13. Zhang, A., Chang, T.P.O., and Altura, B.M. (1992) Magnesium Regulates Intracellular Free Ionized Calcium Concentration and Cell Geometry in Vascular Smooth Muscle Cells, Biochim. Biophys. Acta Mol. Cell Res. 1134, 25-29.
14. Altura, B.M., and Altura, B.T. (1970) Differential Effects of Substrate Depletion on Drug-Induced Contractions of Rabbit Aorta, Am. J. Physiol. 219, 1698-1705.
15. i: Relation to Etiology of Alcohol-Induced Stroke, Alcohol 14, 367-371.
16. Furchgott, R.E., and Vanhoutte, P.M. (1989) Endothelium-Derived Relaxing and Contracting Factors, FASEB J. 3, 2007-2018.
17. 3-induced HL-60 Cell Differentiation, J. Biol. Chem. 265, 15823-15831.
18. Gomez-Muñoz, A., Martin, A., O'Brien, L., and Brindley, D.N. (1994) Cell-Permeable Ceramides Inhibit the Stimulation of DNA Synthesis and Phospholipase D Activity by Phosphatidate and Lysophosphatidate in Rat Fibroblast, J. Biol. Chem. 269, 8937-8943.
19. Nakamura, Y., Nakashima, S., Ojio, K., Banno, Y., Miyata, H., and Nozawa, Y. (1996) Ceramide Inhibits IgE-Mediated Activation of Phospholipase D, but Not of Phospholipase C, in Rat Basophilic Leukemia (RBL-2H3) Cells, J. Immunol. 156, 256-262.
20. 2-ceramide) Inhibited Neutrophil Superoxide Formation and Calcium Influx, J. Biol. Chem. 270, 3056-3062.
21. Negishi, T., Chik, C.L., and Ho, A.K. (1998) Ceramide Selectively Inhibits Calcium-Mediated Potentiation of β-Adrenergic-Stimulated Cyclic Nucleotide Accumulation in Rat Pinealocyte, Biochem. Biophys. Res. Commun. 244, 57-61.
22. 2+ Current in Adult Rat Ventricular Myocytes, Am. J. Physiol. 272, H2591-H2598.
23. Dobrowsky, R.T., Kamibayashi, C., Mumby, M.C., and Hannun, Y.A. (1993) Ceramide Activates Heterotrimeric Protein Phosphatase 2A, J. Biol. Chem. 268, 15523-15530.
24. Winder, S.J., Pato, M.D., and Walsh, M.P. (1992) Purification and Characterization of Calponin Phosphatase from Smooth Muscle: Effect of Dephosphorylation on Calponin Function, Biochem. J. 286, 197-203.
25. Pato, M.D., Sutherland, C., Winder S.J., and Walsh, M.P. (1993) Smooth-Muscle Caldesmon Phosphatase Is SMP-1, a Type 2A Protein Phosphatase, Biochem. J. 293, 35-41.
26. Lee, M.W., and Severson, D.L. (1994) Signal Transduction in Vascular Smooth Muscle: Diacylglycerol Second Messengers and PKC Action, Am. J. Physiol. 267, C659-C678.
27. Walsh, M.P., Kargacin, G.J., Kendrick-Jones, J., and Lincoln, T.M. (1995) Intracellular Mechanisms Involved in the Regulation of Vascular Smooth Muscle Tone, Can. J. Physiol. Pharmacol. 73, 565-573.