High seropositivity of anti-CagA antibody in Helicobacter pylori- Infected patients irrelevant to peptic ulcers and normal mucosa in Japan

Digestive Diseases and Sciences

Volumn 42, Issue 9, 1997, Pages 1841-1847

  Maeda, Shin ^a   Kanai, Fumihiko ^a   Ogura, Keiji ^a   Yoshida, Haruhiko ^a   Ikenoue, Tsuneo ^a   Takahashi, Morio ^a   Kawabe, Takao ^a   Shiratori, Yasushi ^a   Omata, Masao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Anti CagA antibody; CagA; Gastroduodenal disease; Helicobacter pylori; Recombinant protein

Indexed keywords

ADULT; ARTICLE; BACTERIUM DETECTION; CONTROLLED STUDY; CORRELATION FUNCTION; DIAGNOSTIC VALUE; FEMALE; GASTRODUODENAL ULCER; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MALE; PEPTIC ULCER; PRIORITY JOURNAL; SERODIAGNOSIS; STOMACH MUCOSA;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; FEMALE; GASTRIC MUCOSA; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; JAPAN; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PEPTIC ULCER; PREVALENCE; RABBITS; SEROEPIDEMIOLOGIC STUDIES; STOMACH NEOPLASMS;

EID: 0030849535     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018846723379     Document Type: Article

References (20)

1. NIH Consensus Conference: Helicobacter pylori in peptic ulcer disease. NIH consensus development panel on Helicobacter pylori in peptic ulcer disease. JAMA 272:65-69, 1994
2. Graham DY, Lew GM, Klein PD, Evans DG, Evans DJ, Saeed ZA, Malaty HM: Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer: A randomized, controlled study. Ann Intern Med 116:705-708, 1992
3. Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Richard KS: Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 325:1127-1131, 1991
4. Nomura A, Stemmermann GN, Chyou PH, Kato I, Perez-Perez GI, Blaser MJ: Helicobacter pylori infection and gastric carcinoma among Japanese American in Hawaii. N Engl J Med 325:1132-1136, 1991
5. Blaser MJ, Perez-Perez GI, Cover TL, Peek RM, Chyou PH, Stemmermann GN, Nomura A: Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of stomach. Cancer Res 55:2111-2115, 1995
6. Ching CK, Wong BCY, Kwok E, Ong L, Covacci A, Lam SK: Prevalence of CagA-bearing Helicobacter pylori strains detected by the anti-CagA assay in patients with peptic ulcer disease and in controls. Am J Gastroenterol 41:944-953, 1996
7. + Helicobacter pylori strains. J Clin Microbiol 33:1496-1500, 1995
8. Crabtree JE, Farmery SM, Lindley IKD, Figura N, Peichl P, Tompkins DS: CagA/cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines. J Clin Pathol 47:945-950, 1994
9. Graham DY, Genta RM, Graham DP, Crabtree JE: Serum CagA antibodies in asymptomatic subjects and patients with peptic ulcer: Lack of correlation of IgG antibody in patients with peptic ulcer or asymptomatic Helicobacter pylori gastritis. J Clin Pathol 49:829-832, 1996
10. Miehlke S, Kibler K, Kim JG, Figure N, Small SM, Graham DY, Go MF: Allelic variation in the cagA Gene of Helicobacter pylori obtained from Korea compared to the United States. Am J Gastroenterol 41:1322-1325, 1996
11. Yamaoka Y, Kita M, Kodama T, Sawai N, Imanishi J: Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa. Gastroenterology 110:1744-1752, 1996
12. Awakawa T, Sugiyama T, Hisano K, Karita M, Yachi A: Detection and identification of cagA of Helicobacter pylori by polymerase chain reaction. Eur J Gastroentrol Hepatol 5 (suppl):S75-S78, 1995
13. Covacci A, Censini S, Bugnoli M, Petracca R, Burroni D, Macchia G, Massone A, Papini E, Xiang Z, Figura N, Rappuoli R: Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA 90:5791-5795, 1993
14. Tummuru MKR, Cover TL, Blaser MJ: Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: Evidence of linkage to cytotoxin production. Infect immun 61:1799-1809, 1993
15. Sanger F, Nicklen S, Coulson AR: DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467, 1977
16. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680, 1970
17. Kawamata O, Yoshida H, Hirota K, Yoshida A, Kawaguchi R, Shiratori Y, Omata M: Nested-polymerase chain reaction for the detection of Helicobacter pylori infection with novel primers designed by sequence analysis of urease A gene in clinically isolated bacterial strains. Biochem Biophys Res Commun 219:266-272, 1996
18. Hochuli E, Dobeli H, Schacher A: New metal chelate adsorbent selective for proteins and peptides containing neighboring histidine residues. J Chromatog 411:177-184, 1987
19. Ogura K, Kanai F, Maeda S, Yoshida H, Ogura M, Lan KH, Hirota K, Kawabe T, Shiratori Y, Omata M: High prevalence of cytotoxin-positive Heticobacter pylori in patients irrelevant to the presence of peptic ulcers in Japan. Gut (in press)
20. Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, Rappuoli R, Covacci A: cag, a pathogenicity island of Helicobacter pylori, encodes type I-specitic and disease-associated virulence factors. Proc Natl Acad Sci USA 93:14648-14653, 1996