Pharmacokinetic/pharmacodynamic modeling of antipyretic and anti-inflammatory effects of naproxen in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 1, 2001, Pages 198-205

  Josa, M ^a   Urizar, J P ^a   Rapado, J ^a   Dios Vieitez C ^a   Castaneda Hernandez G ^a   Flores Murrieta, F ^a   Renedo, M J ^a   Troconiz, I F ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; BACTERIUM LIPOPOLYSACCHARIDE; DICLOFENAC; IBUPROFEN; NAPROXEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; BASAL BODY TEMPERATURE; BIOSYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGRADATION; DISEASE MODEL; DRUG ABSORPTION; DRUG EFFECT; EDEMA; FEVER; IC 50; INFLAMMATION; MALE; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION TIME;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; MALE; MODELS, BIOLOGICAL; NAPROXEN; RATS; RATS, WISTAR;

EID: 0035079038     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Serum protein binding of nonsteroidal anti-inflammatory drugs: A comparative study
2. Integrated pharmacokinetic-pharmacodynamic model for acetaminophen, ibuprofen and placebo antipyresis in children
3. Involvement of cyclooxygenase-2 in lps-induced fever and regulation of its mRNA by lps in the rat brain
4. Relationship between naproxen plasma concentration and its anti-inflammatory effect in experimental hepatitis
5. Noxious stimulus-induced increase in spinal prostaglandin E2 is noradrenergic terminal dependent
6. Clinical pharmacokinetics of naproxen
7. Choosing the right non-steroidal antiinflammatory drug for the right patient. A pharmacokinetic approach
8. Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine
9. Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model
10. Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine
11. Estimated rate of prostacyclin secretion into the circulation of normal man
12. Pharmacodynamic modeling of nonsteroidal anti-inflammatory drugs: Antipyretic effect of ibuprofen
13. Pharmacokinetic-pharmacodynamic modeling of the immunomodulating agent susalimod and experimentally induced tumor necrosis factor-α levels in the mouse
14. Relationship between pharmacokinetics and the analgesic effect of ketorolac in the rat
15. Down-regulation models and modelling of testosterone production induced by recombinant human choriogonadotropin
16. Xpose: An S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM
17. Pharmacokinetics and pharmacodynamics of ibuprofen isomers and acetaminophen in febrile children
18. Fever: Role of pyrogens and cryogens
19. Enantio-specific pharmacokinetics and pharmacodynamics of ketoprofen in sheep
20. Pharmacokinetics and pharmacodynamics of ketoprofen enantiomers in the horse
21. Cyclooxygenase knockout mice
22. Relationships between biophasic disposition and pharmacokinetic behavior in nonsteroid antiinflammatory drugs
23. Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: Light and electron microscopic immunocytochemical studies
24. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
25. Effect of endotoxin and interleukin-1beta on corticotropin-releasing-factor and prostaglandin release by rat brainstem slices
26. Prostaglandin E2 may induce hyperthermia through EP1 receptor in the anterior wall of the third ventricle and neighboring preoptic regions
27. Perfusion of vasopressin within the rat brain suppresses prostaglandin E-hyperthermia
28. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
29. Pharmacological analysis of cyclooxygenase-1 in inflammation
30. Pharmacokinetic-pharmacodynamic modelling of the antipyretic effect of two oral formulations of ibuprofen
31. Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs
32. Individual differences in response to lps and psychological stress in aged rats
33. Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs
34. Behavioral effects of lipopolysaccharide in rats: Involvement of endogenous opioids
35. Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production