Morphology of early choroidal neovascularisation in age-related macular degeneration: Correlation with activity

Eye

Volumn 11, Issue 4, 1997, Pages 515-522

  Sarks, J P ^a,c   Sarks, S H ^a   Killingsworth, M C ^b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b SYDNEY SOUTH WEST AREA HEALTH SERVICE   (Australia)

^c NONE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN;

AGED; ANGIOGENESIS; ARTICLE; BASEMENT MEMBRANE; BRUCH MEMBRANE; CADAVER; CASE REPORT; CHOROID CAPILLARY LAYER; CHOROID VASCULARIZATION; ENDOTHELIUM CELL; ERYTHROCYTE; EXTRAVASATION; GIANT CELL; HUMAN; HUMAN TISSUE; MACROPHAGE; MALE; MEMBRANE DAMAGE; MORPHOLOGY; PATIENT; PERICYTE; PIGMENT EPITHELIUM; RETINA MACULA DEGENERATION; SUBRETINAL NEOVASCULARIZATION;

EID: 0030805978     PISSN: 0950222X     EISSN: None     Source Type: Journal    
DOI: 10.1038/eye.1997.137     Document Type: Article

References (30)

1. Sarks SH. New vessel formation beneath the retinal pigment epithelium in senile eyes. Br J Ophthalmol 1973;57:951-65.
2. Green WR, McDonnell PJ, Yeo JH. Pathologic features of senile macular degeneration. Ophthalmology 1985;92:615-27.
3. Sarks SH. Ageing and degeneration in the macular region: a clinico-pathological study. Br J Ophthalmol 1976;60:324-41.
4. Gregor Z, Bird AC, Chisholm IH. Senile disciform macular degeneration in the second eye. Br J Ophthalmol 1977;61:141-7.
5. Bressler SB, Macquarie MG, Bressler NM, Fine SL. The Macular Photocoagulation Study Group. Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. Arch Ophthalmol 1990;108:1442-7.
6. Killingsworth MC. Angiogenesis in early choroidal neovascularization secondary to age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 1995;233:313-23.
7. Killingsworth MC, Sarks JP, Sarks SH. Macrophages related to Bruch's membrane in age-related macular degeneration. Eye 1990;4:613-21.
8. Sarks JP, Sarks SH, Killingsworth MC. Evolution of soft drusen in age-related macular degeneration. Eye 1994;8:269-83.
9. Seregard S, Algvere PV, Berglin L. Immunohistochemical characterization of surgically removed subfoveal fibrovascular membranes. Graefes Arch Clin Exp Ophthalmol 1994;232:325-9.
10. Yamagami I. Electron microscopic study of the cornea. 1. The mechanism of experimental new vessel formation. Jpn J Ophthalmol 1970;14:41-58.
11. Green W, Enger C. Age-related macular degeneration: histopathologic studies. The 1992 Lorenz E. Zimmerman lecture. Ophthalmology 1993;100:1519-35.
12. Penfold PL. Senile macular degeneration: the involvement of immunocompetent cells. Graefes Arch Clin Exp Ophthalmol 1985;223:69-76.
13. Dastgheib K, Green WR. Granulomatous reaction to Bruch's membrane in age-related macular degeneration. Arch Ophthalmol 1994;112:813-8.
14. Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359:843-5.
15. Forrester JV, Chapman A, Kerr C, Roberts J, Lee WR, Lackie JM. Bovine retinal explants cultured in collagen gels: a model system for the study of proliferative retinopathy. Arch Ophthalmol 1990;108:415-20.
16. McLeod DS, Lutty GA. High-resolution histologic analysis of the human choroidal vasculature. Invest Ophthalmol Vis Sci 1994;35:3799-811.
17. Miller H, Miller B, Ishibashi T, Ryan SJ. Pathogenesis of laser-induced choroidal subretinal neovascularization. Invest Ophthalmol Vis Sci 1990;31:899-908.
18. Gass DJ. Biomicroscopic and histopathologic considerations regarding the feasibility of surgical excision of subfoveal neovascular membranes. Trans Am Ophthalmol Soc 1994;92:91-116.
19. Folkman J, Haudenschild C. Angiogenesis in vitro. Nature 1980;288:551-6.
20. Folkman J, Klaesbrun M. Angiogenic factors. Science 1987;235:442-7.
21. Ausprunk DH, Folkman J. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res 1977;14:53-65.
22. Ishibashi T, Miller H, Orr G, Sorgente N, Ryan SJ. Morphologic observations on experimental subretinal neovascularization in the monkey. Invest Ophthalmol Vis Sci 1987;28:1116-30.
23. Ishibashi T, Inomata H, Sakamoto T, Ryan SJ. Pericytes of newly formed vessels in experimental subretinal neovascularization. Arch Ophthalmol 1995;113:227-31.
24. Orlidge-Antonelli A, Smith SR, D'Amore PA. Influence of pericytes on capillary endothelial cell growth. Am Rev Respir Dis 1989;140:1129-31.
25. Miller H, Miller B, Ryan SJ. Correlation of choroidal subretinal neovascularization with fluorescein angiography. Am J Ophthalmol 1985;99:263-71.
26. Maurice DM, Gaubermann H, Michaelson IC. Stimulus to neovascularisation in the cornea. Exp Eye Res 1966;5:163-84.
27. Lopez PF, Lambert HM, Grossniklaus HE, Sternberg P Jr. Well-defined subfoveal choroidal neovascular membranes in age-related macular degeneration. Ophthalmology 1993;100:415-22.
28. Lopez PF, Grossniklaus HE, Lambert HM, Aaberg TM, Capone A Jr, Sternberg P Jr, L'Hernault N. Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration. Am J Ophthalmol 1991;112:647-56.
29. Lee BL, Lim JI, Grossniklaus HE. Clinicopathologic features of indocyanine green angiography-imaged, surgically excised choroidal neovascular membranes. Retina 1996;16:64-9.
30. Sims DE, Miller F, Perricone MA. A role of pericytes in skeletal muscle vasculature during macromolecular leakage. Microvasc Res 1985;29:250.