The role of catalytic cleft and exosite residues of factor VIIa for complex formation with tissue factor pathway inhibitor

Thrombosis and Haemostasis

Volumn 85, Issue 3, 2001, Pages 458-463

  Iakhiaev, A ^a   Ruf, W ^a   Rao, L V M ^a  

^a UNIVERSITY OF TEXAS AT TYLER   (United States)

Author keywords

Factor VIIa; Factor Xa; Protein interaction; Tissue factor; Tissue factor pathway inhibitor

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; CELL SURFACE RECEPTOR; DETERGENT; PHOSPHOLIPID; PROTEINASE; TISSUE FACTOR PATHWAY INHIBITOR;

ALLOSTERISM; ARTICLE; BINDING SITE; CATALYSIS; CELL SURFACE; COMPLEX FORMATION; CONCENTRATION RESPONSE; ENZYME ACTIVITY; ENZYME SUBSTRATE; EXPERIMENTAL MODEL; INHIBITION KINETICS; MICELLE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; STRUCTURE ANALYSIS;

EID: 0035077045     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615605     Document Type: Article

References (35)

1. The tissue factor pathway: How it has become a "prima ballerina"
2. Allosteric regulation of the cofactor dependent serine protease coagulation factor VIIa
3. Regions remote from the site of cleavage determine macromolecular substrate recognition by the prothrombinase complex
4. Macromolecular substrate affinity for the tissue factor-factor VIIa complex is independent of scissile bond docking
5. Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease
6. Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor VIIa protease
7. Importance of factor VIIa Gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X Gla-domain
8. Engineered recombinant factor VII Q217 variants with altered inhibitor specificities
9. Factor VIIa residue Arg290 is required for efficient activation of the macromolecular substrate factor X
10. The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: Insight into its possible mechanism of action
11. The extrinsic pathway inhibitor: A regulator of tissue factor-dependent blood coagulation
12. Modifications of extrinsic pathway inhibitor (EPI) and factor Xa that affect their ability to interact and to inhibit factor VIIa/tissue factor: Evidence for a two-step model of inhibition
13. Regulation of coagulation by a multivalent kunitz-type inhibitor
14. Functional significance of the kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor
15. Inhibition of factor VIIa-tissue factor coagulation activity by a hybrid protein
16. Mechanisms of binding of recombinant extrinsic pathway inhibitor (rEPI) to cultured cell surfaces. Evidence that rEPI can bind to and inhibit factor VIIa-tissue factor complexes in the absence of factor Xa
17. Inhibitory properties of full-length and truncated recombinant tissue factor pathway inhibitor (TFPI). Evidence that the third kunitz-type domain of TFPI is not essential for the inhibition of factor VIIa-tissue factor complexes on cell surfaces
18. Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant
19. Alteration of the substrate and inhibitor specificities of blood coagulation factor VIIa: Importance of amino acid residue K192
20. Tissue factor residues Lys165 and Lys166 are essential for rapid formation of quaternary complex of tissue factor. VIIa with Xa. tissue factor pathway inhibitor
21. Regulation of extrinsic pathway factor Xa formation by tissue factor pathway inhibitor
22. An anti-tissue factor monoclonal antibody which inhibits TF.VIIa complex is a potent anticoagulant in plasma
23. Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa
24. Recombinant soluble human tissue factor secreted by saccharomyces cerevisiae and refolded
25. Regulation of the catalytic function of coagulation factor VIIa by a conformational linkage of surface residue Glu 154 to the active site
26. A simplified procedure for purification of human prothrombin, factor IX and factor X
27. Factor VIIa/tissue factor-catalyzed activation of factors IX and X on a cell surface and in suspension: A kinetic study
28. Kinetics of the inhibition of tissue factor-factor VIIa by tissue factor pathway inhibitor
29. Kinetics of the inhibition of factor Xa and the tissue factor-factor VIIa complex by the tissue factor pathway inhibitor in the presence and absence of heparin
30. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor
31. SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modeling
32. Manipulation of the membrane binding site of vitamin K-dependent proteins: Enhanced biological function of human factor VII
33. Kinetics of slow and tight-binding inhibitors
34. Characterization of factor VII association with tissue factor in solution
35. Kinetics of the inhibition of tissue factor-factor VIIa by tissue factor pathway inhibitor