Transcription elongation complex: Structure and function

Current Opinion in Microbiology

Volumn 4, Issue 2, 2001, Pages 119-125

  Korzheva, Nataliya ^a   Mustaev, Arkady ^a  

^a PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELONGATION FACTOR; RNA POLYMERASE;

DNA SEQUENCE; MOLECULAR MODEL; PEPTIDE MAPPING; PROTEIN RNA BINDING; REVIEW; RNA BINDING; RNA SYNTHESIS; RNA TRANSCRIPTION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION; X RAY ANALYSIS;

BACTERIA (MICROORGANISMS);

EID: 0035074008     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(00)00176-4     Document Type: Review

References (46)

1. Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases
2. Crystal structure of Thermus aquaticus RNA polymerase at 3.3 Å resolution
3. Architecture of RNA polymerase II and implications for the transcription mechanism
4. A structural model of transcription elongation
5. Structural organization of the RNA polymerase-promoter open complex
6. The orientation of DNA in an archaeal transcription initiation complex
7. Development of RNA polymerase-promoter contacts during open complex formation
8. Nuclease cleavage of the upstream half of the nontemplate strand DNA in an Escherichia coli transcription elongation complex causes upstream translocation and transcriptional arrest
9. Translocation of the Escherichia coli transcription complex observed in the registers 11 to 20: 'Jumping' of RNA polymerase and asymmetric expansion and contraction of the 'transcription bubble'
10. Mechanistic model of the elongation complex of Escherichia coli RNA polymerase
11. Transcription processivity: Protein-DNA interactions holding together the elongation complex
12. Mapping of catalytic residues in the RNA polymerase active center
13. Promoter proximal sequences modulate RNA polymerase II elongation by a novel mechanism
14. Transcriptional arrest: Escherichia coli RNA polymerase translocates backward, leaving the 3′ end of the RNA intact and extruded
15. RNA polymerase switches between inactivated and activated states by translocating back and forth along the DNA and the RNA
16. The RNA-DNA hybrid maintains the register of transcription by preventing backtracking of RNA polymerase
17. In vivo evidence for back and forth oscillations of the transcription elongation complex
18. Transcript elongation and termination
19. A thermodynamic analysis of RNA transcript elongation and termination in Escherichia coli
20. New models for mechanism of transcription elongation and its regulation
21. Basic mechanisms of transcript elongation and its regulation
22. Structural analysis of ternary complexes of Escherichia coli RNA polymerase: Ribonuclease footprinting of the nascent RNA in complexes
23. Crucial role of the RNA:DNA hybrid in the processivity of transcription
24. Spatial organization of transcription elongation complex in Escherichia coli
25. RNA polymerase slides home: Pause and termination site recognition
26. Footprinting analysis of mammalian RNA polymerase II along its transcript: An alternative view of transcription elongation
27. Functional topography of nascent RNA in elongation intermediates of RNA polymerase
28. Determinants of the stability of transcription elongation complexes: Interactions of the nascent RNA with the DNA template and the RNA polymerase
29. Interaction of a nascent RNA structure with RNA polymerase is required for hairpin-dependent transcriptional pausing but not for transcript release
30. Mechanism of intrinsic transcription termination and antitermination
31. RNA displacement pathways during transcription from synthetic RNA-DNA bubble duplexes
32. Attachment of nascent RNA molecules to superhelical DNA
33. Prediction of rho-independent Escherichia coli transcription terminators. A statistical analysis of their RNA stem-loop structures
34. Contributions of RNA secondary structure and length of the thymidine tract to transcription termination at the thr operon attenuator
35. Functional importance of sequence in the stem-loop of a transcription terminator
36. Transcription termination at intrinsic terminators: The role of the RNA hairpin
37. Escherichia coli RNA polymerase terminates transcription efficiently at rho-independent terminators on single-stranded DNA templates
38. The mechanism of intrinsic transcription termination
39. Shifting RNA polymerase into overdrive
40. Transcription elongation: Structural basis and mechanisms
41. Discontinuous movements of DNA and RNA in RNA polymerase accompany formation of a paused transcription complex
42. Coupling between transcription termination and RNA polymerase inchworming
43. Transcription attenuation
44. Pausing by bacterial RNA polymerase is mediated by mechanistically distinct classes of signals
45. RNA polymerase structure-function: Insights into points of transcriptional regulation
46. Transcript cleavage factors from E. coli