Immunopathology of immune-mediated (type 1) diabetes

Clinics in Laboratory Medicine

Volumn 21, Issue 1, 2001, Pages 15-30

  Marker, J ^a   Maclaren, N ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; VACCINE;

AUTOIMMUNITY; BACTERIAL INFECTION; EARLY DIAGNOSIS; ENVIRONMENTAL FACTOR; GENETIC PREDISPOSITION; HUMAN; IMMUNE MEDIATED INJURY; IMMUNE SYSTEM; IMMUNOPATHOLOGY; IMMUNOREGULATION; INSULIN DEPENDENT DIABETES MELLITUS; NATURAL KILLER CELL; PARASITOSIS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; VIRUS INFECTION;

DIABETES MELLITUS, TYPE 1; HUMANS; ISLETS OF LANGERHANS;

EID: 0035073561     PISSN: 02722712     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (85)

1. Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes
2. Functional diversity of helper T lymphocytes
3. Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes
4. What causes diabetes?
5. Are insulin autoantibodies markers for insulin-dependent diabetes mellitus?
6. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
7. Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus
8. Coxsackie B, mumps, rubella, and cytomegalovirus specific IgM responses in patients with juvenile-onset insulin-dependent diabetes mellitus in Britain, Austria, and Australia
9. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
10. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus
11. Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes
12. Starvation in man
13. Age and family relationship accentuate the risk of insulin-dependent diabetes mellitus (IDDM) in relatives of patients with IDDM
14. Virologic, immunologic, and genetic factors in insulin-dependent diabetes mellitus
15. Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity
16. Genetics of diabetes. Genes and environment
17. Influence of phosphorylation on the interaction of effectors with rat liver pyruvate kinase
18. Mechanisms of hormonal regulation of hepatic glucose metabolism
19. The pathology of the endocrine pancreas in type 1 (insulin-dependent) diabetes mellitus
20. Differential sensitivity to beta-cell secretagogues in "early," type I diabetes mellitus
21. Genetic analysis of immune dysfunction in nonobese diabetic (NOD) mice: Mapping of a susceptibility locus close to the Bc1-2 gene correlates with increased resistance of NOD T cells to apoptosis induction
22. The endocrine pancreas. Functional morphology and histopathology
23. Lack of glucagon response to hypoglycemia in diabetes: Evidence for an intrinsic pancreatic alpha cell defect
24. Congenital rubella syndrome as a model for type 1 (insulin-dependent) diabetes mellitus: Increased prevalence of islet cell surface antibodies
25. Myocarditis and insulitis following coxsackie virus infection
26. Analysis of cytokine mRNA expression in pancreatic islets of nonobese diabetic mice
27. Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
28. Although DR3-DQB1*0201 may be associated with multiple component diseases of the autoimmune polyglandular syndromes, the human leukocyte antigen DR4-DQB1*0302 haplotype is implicated only in beta-cell autoimmunity
29. Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice
30. Pancreatic islet-cell damage in children with fatal viral infections
31. A review of the recent epidemiological data on the worldwide incidence of type 1 (insulin-dependent) diabetes mellitus
32. T helper cell subsets in insulin-dependent diabetes
33. A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus
34. Regulation of initiation of protein synthesis by insulin in skeletal muscle
35. Commentary: Autoimmunity and diabetes
36. Cryptic epitope and autoimmunity
37. IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus
38. Islet-cell antibodies in juvenile diabetes mellitus of recent onset
39. Concordance between twins for beta-cell autoimmunity
40. Th1 and Th2 CD4 + T cells in the pathogenesis of organ-specific autoimmune diseases
41. Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: Precursor of the 37-kDa tryptic fragment
42. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain
43. Is insulin-dependent diabetes mellitus environmentally induced?
44. Antibody to cultured human insulinoma cells in insulin-dependent diabetes
45. Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (type 1) diabetes in relatives
46. Insulin-dependent diabetes mellitus: The hypothesis of molecular mimicry between islet cell antigens and microorganisms
47. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
48. Residual beta-cell function and HLA-A24 in IDDM: Markers of glycemic control and subsequent development of diabetic retinopathy
49. Molecular basis for HLA-DQ associations with IDDM
50. HLA-antigens and diabetes mellitus
51. Islet cell and other organ-specific antibodies in U.S. Caucasians and Blacks with insulin-dependent diabetes mellitus
52. IA-2 and IA-2 beta are major autoantigens in IDDM and the precursors of the 40 kDa and 37 kDa tryptic fragments
53. Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis
54. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
55. Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice
56. Immunization therapies in the prevention of diabetes
57. Mechanisms decreasing glucose oxidation in diabetes and starvation: Role of lipid fuels and hormones
58. Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes
59. An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes
60. Beta-cell autoantibodies in infants and toddlers without IDDM relatives: Diabetes autoimmunity study in the young (DAISY)
61. Dendritic cells in the autoimmune insulitis in NOD mouse models of diabetes
62. Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: Correlation with the development of diabetes
63. Autoantigen-independent deletion of diabetogenic CD4+ thymocytes by protective MHC class II molecules
64. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
65. B lymphocytes are critical antigenpresenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice
66. Susceptibility to type I diabetes: HLA-DQ and DR revisited
67. Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type 1 diabetes mellitus
68. An Epstein-Barr virus-associated superantigen
69. Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to type 1 (insulin-dependent) diabetes mellitus
70. Insulin-dependent diabetes mellitus
71. Genetic control of autoimmunity in type 1 diabetes
72. Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic mice
73. Development of autoimmune insulitis is prevented in E alpha d but not in A beta k NOD transgenic mice
74. Diabetes mellitus
75. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
76. Uber "insulitis" bei diabetes
77. Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB rats
78. Molecular mimicry in diabetes mellitus: The homologous domain in coxsackie B virus protein 2C and islet autoantigen GAD65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule
79. Genetic analysis of autoimmune disease
80. The role of CD8 + T cells in the initiation of insulin-dependent diabetes mellitus
81. In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes
82. Genetic control of autoimmune diabetes in the NOD mouse
83. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis
84. Cellular and molecular mechanisms for the initiation and progression of beta cell destruction resulting from the collaboration between macrophages and T cells
85. Prophylactic insulin treatment in relatives at high risk for type 1 diabetes