Molecular mimicry in diabetes mellitus: The homologous domain in coxsackie B virus protein 2C and islet autoantigen GAD65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule

Diabetologia

Volumn 41, Issue 1, 1998, Pages 40-46

  Vreugdenhil, G R ^a   Geluk, A ^b   Ottenhoff, T H M ^b   Melchers, W J G ^a   Roep, B O ^b   Galama, J M D ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Coxsackie B virus; HLA DR; IDDM; Molecular mimicry; Peptide binding

Indexed keywords

AUTOANTIGEN; GLUTAMATE DECARBOXYLASE; HLA DR1 ANTIGEN; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; VIRUS PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; B LYMPHOBLAST; CONTROLLED STUDY; COXSACKIE VIRUS B; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOBLASTOID CELL LINE; MOLECULAR MIMICRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; T LYMPHOCYTE;

AMINO ACID SEQUENCE; AUTOANTIGENS; BASE SEQUENCE; BINDING SITES; CARRIER PROTEINS; CONSERVED SEQUENCE; DIABETES MELLITUS, TYPE 1; DNA PRIMERS; ENTEROVIRUS B, HUMAN; GLUTAMATE DECARBOXYLASE; HLA-DR1 ANTIGEN; HLA-DR3 ANTIGEN; HLA-DR4 ANTIGEN; HUMANS; ISLETS OF LANGERHANS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0031883094     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050864     Document Type: Article

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