Cell adhesion molecules in human osteoblasts: Structure and function

Histology and Histopathology

Volumn 16, Issue 2, 2001, Pages 603-611

  Bennett, J H ^a   Moffatt, S ^a   Horton, M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Adhesion; Cadherin; Differentiation; Integrin; Osteoblast

Indexed keywords

CADHERIN; CD44V ANTIGEN; CELL ADHESION MOLECULE; COLLAGEN; FIBRONECTIN; IMMUNOGLOBULIN; INTEGRIN; SELECTIN; SYNDECAN;

BONE DEVELOPMENT; BONE MATRIX; CELL ACTIVITY; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL INTERACTION; CELL PROLIFERATION; CYTOPLASM; HOMEOSTASIS AND REGULATION; HUMAN; OSTEOBLAST; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVIEW; SKELETON;

CADHERINS; CELL ADHESION; CELL ADHESION MOLECULES; CELL COMMUNICATION; CELL DIFFERENTIATION; EXTRACELLULAR MATRIX; HUMANS; INTEGRINS; LIGANDS; OSTEOBLASTS; SIGNAL TRANSDUCTION;

EID: 0035070367     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (109)

1. Integrin expression in a mandibular explant model of osteoblast differentiation
2. Adhesive properties of isolated chick osteocytes in vitro
3. The short amino acid sequence of Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function
4. Marrow adipocytes and fibroblasts have osteogenic potential
5. Differential regulation of syndecan expression by osteosarcoma cell lines in response to cytokines but not osteotropic hormones
6. β1 integrin is essential for teratoma growth and angiogenesis
7. Genetic analysis of β1 integrin function: Confirmed, new and revised roles for a crucial family of cell adhesion molecules
8. Identification of integrin cell-sustratum adhesion receptors on cultured rat bone cells
9. Mesenchymal stem cells in osteobiology and applied bone regeneration
10. Mesenchymal stem cell surface antigen SB-10 corresponds to activated leucocyte cell adhesion molecule and is involved in osteogenic differentiation
11. Changes in trabecular bone, haematopoesis and bone marrow vessels in aplastic anaemia, primary osteoporosis and old age. A comparative histomorphometric study
12. Immunolocalization of collagen types I and II, tenascin, and fibronectin in intramembranous bone
13. Integrin-mediated signal transduction pathways
14. Human osteoblasts express a repertoire of cadherins which are critical in BMP-2 induced osteogenic differentiation
15. Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells
16. Integrins and signal transduction pathways: The road taken
17. Are MG-63 and HOS TE85 human osteosarcoma cell lines representative models of the osteoblastic phenotype?
18. Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture
19. Bi-directional signal transduction by integrin receptors
20. Mineralisation and the expression of matrix proteins during in vivo bone development
21. Integrin-linked kinase (ILK): A regulator of integrin and growth-factor signalling
22. Alterations in integrin receptor expression on chemically transformed human cells: Specific enhancement of laminin and collagen receptor complexes
23. Genetic determination of Colles' fracture and differential bone mass in women with and without Colles' fracture
24. Morphological evidence of gap junctions between bone cells
25. The cell and molecular biology of fracture healing
26. Consequences of lack of beta 1 integrin gene expression in mice
27. Genetic analyses of integrin function in mice
28. A role for N-cadherin in the development of the differentiated osteoblastic phenotype
29. Precursor cells of mechanocytes
30. Definition of two angiogenic pathways by distinct αv integrins
31. Ascorbic acid alters collagen integrins in bone culture
32. VEGF couples hypertrophic cartilage remodelling, ossification and angiogenesis during endochondral bone formation
33. Integrin signalling
34. Fibronectin is a survival factor for differentiated osteoblasts
35. Immunogold localization of beta-1 integrin in bone: Effect of glucocorticoids and insulin-like growth factor I on integrins and osteocyte formation
36. Response of human osteoblasts to implant materials: Integrin-mediated adhesion
37. Integrin expression and function on human osteoblast-like cells
38. Bone matrix RGD glycoproteins: Immunolocalisation and interaction with human primary osteoblastic bone cells in vitro
39. Integrins and adhesion molecules
40. Beta 1 integrins and osteoclast function: Involvement in collagen recognition and bone resorption
41. The alpha v beta 3 integrin "vitronectin receptor"
42. Perspectives: Adhesion receptors in bone
43. Integrins as therapeutic targets in bone disease
44. Integrin expression in human bone
45. CD44 expression in human bone: A novel marker of osteocyte differentiation
46. Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin
47. Distribution of integrin subunits on rat metaphyseal osteoclasts and osteoblasts
48. Integrins: A family of cell surface receptors
49. Integrins: Versatility, modulation and signalling in cell adhesion
50. Collagen integrin receptors regulate early osteoblast differentiation induced by BMP-2
51. 2+ in mouse epidermal cells is controlled by cadherin
52. Integrin alpha(2)I domain recognises type I and type IV collagens by different mechanisms
53. Anomalous cadherin expression in osteosarcoma: Possible relationships to metastasis and morphogenesis
54. Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11
55. Distribution of integrins and their matrix ligands in osteogenic sarcomas
56. Interaction of type IV collagen with the isolated integrins alpha 1 beta 1 and alpha 2 beta 1
57. Identification in collagen type I of an integrin α2β1-binding site containing an essential GER sequence
58. Cadherin-6 mediates the heterotopic interactions between the hemopoietic osteoclast cell lineage and stromal cells in a murine model of osteoclast differentiation
59. Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies
60. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Role of integrin aggregation and occupancy of receptors
61. Integrins and cell motility in MG 63 cells
62. Differential expression of fibroblast growth factor receptor -1, -2, and -3 and syndecan-1, -2, and -4 in neonatal rat mandibular condyle and calvaria during osteogenic differentiation in vitro
63. Interactions between integrin receptors and fibronectin are required for calvarial osteoblast differentiation in vitro
64. Fibronectin regulates calvarial osteoblast differentiation
65. Localisation of CD 44, the hyaluronate receptor, on the plasma membrane of osteocytes and osteoclasts in rat tibia
66. Biochemical characterization of human osteoclast integrins. Osteoclasts express alpha v beta 3, alpha 2 beta 1, and alpha v beta 1 integrins
67. Genetics of fracture: Challenges and opportunities
68. Bone morphogenetic protein-2 is a regulator of cell adhesion
69. Spatial distribution of CD44 and hyaluronan in the proximal tibia of the growing rat
70. Molecular cloning and characterisation of cadherin-11, a new member of the cadherin family expressed in osteoblasts
71. Lineage of osteogenic cells and their relationship to the stromal system
72. The marrow stromal cell system
73. Morphological study of intercellular junctions during osteocyte differentiation
74. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
75. Integrin synthesis and utilisation in cultured human osteoblasts
76. Cloning, primary structure and properties of a novel human integrin beta subunit
77. Static and dynamic bone histomorphometry in children with osteogenesis imperfecta
78. Transforming growth factor-β regulates collagen gel contraction by increasing α2β1 integrin expression in osteogenic cells
79. The role of osteogenic cells in the pathophysiology of Paget's disease
80. Selective attachment of osteoprogenitors to laminin
81. p38 MAP kinase activation by vascular endothelial growth factor mediated actin reorganisation and cell migration in human endothelial cells
82. New perspectives in cell adhesion: RGD and integrins
83. Identification of integrins on cultured human bone cells
84. Electrophysiological responses of human bone cells to mechanical stimulation: Evidence for specific integrin function in mechanotransduction
85. Adhesion-growth factor interactions during differentiation: An integrated biological response
86. Integrin signalling and tyrosine phosphorylation: Just the FAK's?
87. αvβ3 integrin associates with activated insulin and PDGF-β receptors and potentiates the biological activity of PDGF
88. Expression of proteoglycan core proteins in human bone marrow stroma
89. Osteogenic potential of vascular pericytes
90. Regulation of human osteoblast integrin expression by orthopaedic implant materials
91. Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor-2
92. Immunohistochemical localization of cell adhesion proteins and integrins in the peridontium
93. Differentiation and cell surface expression of transforming growth factor-beta receptors are regulated by interaction with matrix collagen in murine osteoblastic cells
94. Differentiation and transforming growth factor-β down-regulation by collagen α2β1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells
95. The cadherins: Cell-cell adhesion molecules controlling animal morphogenesis
96. Morphogenetic roles of classic cadherins
97. Osteoblasts are regulated by cellular adhesion through ICAM-1 and VCAM-1
98. The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure
99. Association of insulin receptor substrate-1 with integrins
100. Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing uniques α and β subunits
101. Synthesis and localisation of fibronectin during collagenous matrix-mesenchymal cell interaction and differentiation of cartilage and bone in vivo
102. β1 integrin-dependent and -independent polymerisation of fibronectin
103. ECM and cell surface proteolyis: Regulating cellular ecology
104. The synergystic activity of αvβ3 integrin and PDGF receptor increases cell migration
105. Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: Requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence
106. Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor
107. Functional gap junctions between osteocytic and osteoblastic cells
108. Impaired bone formation in transgenic mice resulting from altered integrin function in osteoblasts