The potential of nucleic acid repair in functional genomics

Nature Biotechnology

Volumn 19, Issue 4, 2001, Pages 321-326

  Rice, M C ^a   Czymmek, K ^a   Kmiec, E B ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; OLIGOMERS; PLANTS (BOTANY); REPAIR; RNA;

FRAMESHIFT MUTATIONS; FUNCTIONAL GENOMICS;

GENES;

ACETOLACTATE SYNTHASE; ADENOSINE DEAMINASE; ANTISENSE OLIGONUCLEOTIDE; BETA GLOBIN; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; DIOLEOYLPHOSPHATIDYLSERINE; DNA; DYSTROPHIN; ENDONUCLEASE; GALACTOSYLCERAMIDE; GREEN FLUORESCENT PROTEIN; HERBICIDE; INTEGRASE; LIPOFECTAMINE; LIPOFECTIN; LIPOSOME; NUCLEIC ACID; OLIGONUCLEOTIDE; POLYETHYLENEIMINE; RIBONUCLEOPROTEIN; RNA; SYNTHETASE;

CHIMERA; DNA REPAIR; DNA SEQUENCE; GENE; GENE MUTATION; GENE TARGETING; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

DNA; DNA DAMAGE; DNA REPAIR; GENOME; MODELS, GENETIC; NUCLEIC ACIDS; OLIGONUCLEOTIDES; PLASMIDS; RECOMBINANT FUSION PROTEINS; RNA; SACCHAROMYCES CEREVISIAE;

ANIMALIA;

EID: 0035069295     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/86701     Document Type: Review

References (48)

1. Ribozymes and their medical implications
2. Ribozymes
3. Progress towards gene therapy for HIV infection
4. Ribozyme-mediated trans-splicing of a trinucleotide repeat
5. Ribozyme-mediated repair of sickle β-globin mRNAs in erythrocyte precursors
6. Evaluating group I intron catalytic efficiency in mammalian cells
7. Repair of Thalassemic human β-globin mRNA in mammalian cells by antisense oligonucleotides
8. Antisense oligonucleotides and RNAs as modulators of pre-mRNA splicing
9. Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides
10. Group II introns designed to insert into therapeutically relevant DNA target sites in human cells
11. Targeted correction of an episomal gene in mammalian cells by short DNA fragment tethered to a triplex-forming oligonucleotide
12. Correction of chromosomal point mutations in human cells with bifunctional oligonucleotides
13. The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts
14. Mechanism and utility of an RNA-cleaving DNA enzyme
15. The excision of intervening sequences from Salmonella 23S ribosomal RNA
16. A complex ligase ribozyme evolved in vitro from a group I ribozyme domain
17. Targeted gene repair
18. A plausible mechanism for gene correction by chimeric oligonucleotides
19. Targeted gene repair directed by chimeric RNA/DNA oligonucleotide in mammalian cell-free extract
20. Genetic repair of mutations in plant cell-free extracts directed by specific chimeric oligonucleotides
21. Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA/DNA oligonucleotide
22. Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide
23. Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric oligonucleotide
24. In-vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides
25. Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide
26. In vivo gene targeting in carbonic anhydrase II deficient mice by chimeric RNA/DNA oligonucleotides
27. Correction of the UDP-glucuronosyltransferase gene defect in the Gunn rat model of Criglar-Najjar syndrome type I with a chimeric oligonucleotide
28. Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA/DNA oligonucleotide
29. Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides
30. In vivo targeted repair of a point mutation in the canine dystrophin gene by a chimeric RNA/DNA oligonucleotide
31. Gene therapy in plants
32. A tool for functional plant genomics: Chimeric RNA/DNA oligonucleotides cause in vivo gene-specific mutations
33. Targeted manipulation of maize genes in vive using chimeric RNA/DNA oligonucleotides
34. Engineering herbicide-resistant maize using chimeric RNA/DNA oligonucleotides
35. Enhancement of strand invasion by oligonucleotides through manipulation of backbone charge
36. Gene transfer in hepatocarcinoma cell lines: In vitro optimization of a virus-free system
37. Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer
38. Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: A stage toward artificial viruses
39. Comparison of cell proliferation and toxicity assays using two cationic liposomes
40. Phosphatidylethanolamine liposomes: Drug delivery, gene transfer and immunodiagnostic applications
41. Enhanced gene transfer into HuH-7 cells and primary rat hepatocytes using targeted liposomes and polyethylenimine
42. Human neonatal lymphocytes immortalized after microinjection of Epstein-Barr virus DNA
43. Glass needle-mediated microinjection of macromolecules and transgenes into primary human blood stem/progenitor cells
44. Specific covalent labeling of recombinant protein molecules inside live cells
45. Pedigree analysis of plasmid segregation in yeast