Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain

British Journal of Pharmacology

Volumn 127, Issue 6, 1999, Pages 1337-1348

  Webster, J Christopher ^a   Francis, Michael M ^b,d   Porter, Julia K ^a   Robinson, Gillian ^a   Stokes, Clare ^a   Horenstein, Ben ^c   Papke, Roger L ^a,b  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c University of Florida   (United States)

^d NONE   (United States)

Author keywords

Ganglionic blockers; Mecamylamine; Nicotine AChR; Voltage clamp; Voltage dependence; Xenopus oocytes

Indexed keywords

MECAMYLAMINE; NICOTINE; NICOTINIC RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BETA CHAIN; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; ELECTRIC POTENTIAL; FEMALE; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT;

AMINO ACID SEQUENCE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FEMALE; MECAMYLAMINE; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUSCLES; NEURONS; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; OOCYTES; POINT MUTATION; RATS; RECEPTORS, NICOTINIC; SENSITIVITY AND SPECIFICITY; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS;

EID: 0032784581     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702686     Document Type: Article

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