Defensins impair phagocytic killing by neutrophils in biomaterial- related infection

Infection and Immunity

Volumn 67, Issue 4, 1999, Pages 1640-1645

  Kaplan, S S ^a,c   Heine, R P ^b   Simmons, R L ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; DACRON; DEFENSIN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; OXYGEN RADICAL; PHORBOL 13 ACETATE 12 MYRISTATE; POLYSTYRENE; PROTEIN ANTIBODY; SILASTIC; SUPEROXIDE; ZYMOSAN;

ARTICLE; BACTERIAL INFECTION; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; NEUTROPHIL; PHAGOCYTOSIS; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

EID: 0033037234     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/.67.4.1640-1645.1999     Document Type: Article

References (79)

1. Absolom, D. R., F. F. Lamberti, Z. Policova, W. Zingg, C. J. van Oss, and A. W. Neumann. 1983. Surface thermodynamics of bacterial adhesion. Appl. Environ. Microbiol. 46:90-97.
2. Arizono, T., M. Oga, and Y. Sugioka. 1992. Increased resistance of bacteria after adherence to polymethyl methacrylate. Acta Orthop. Scand. 63:661-664.
3. Babior, B. M. 1984. Oxidants from phagocytes: agents of defense and destruction. Blood 64:959-966.
4. Baddour, L. M., G. D. Christensen, M. G. Hester, and A. L. Bisno. 1984. Production of experimental endocarditis by coagulase-negative staphylococci: variability in species virulence. J. Infect. Dis. 150:721-727.
5. Borregaard, N., K. Lollike, L. Kyeldsen, H. Sengelov, L. Bastholm, M. H. Nielsen, and D. F. Bainton. 1993. Human neutrophil granules and secretory vesicles. Eur. J. Haematol. 51:187-198.
6. Boyum, A. 1968. Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Investig. 21:77-89.
7. Brunstedt, M. R., S. Sapatnekar, K. R. Rubin, K. M. Kieswetter, N. P. Ziats, K. Merritt, and J. M. Anderson. 1995. Bacteria/blood/material interactions. I. Injected and preseeded slime-forming Staphylococcus epidermidis in flowing blood with biomaterials. J. Biomed. Mater. Res. 29:455-466.
8. Charp, P. A., W. G. Rice, R. L. Raynor, E. Reimund, J. M. Kinkade, T. Ganz, M. E. Selsted, R. I. Lehrer, and J. F. Kuo. 1988. Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils. Biochem. Pharmacol. 37:951-956.
9. Christensen, G. D., W. A. Simpson, A. L. Bisno, and E. H. Beachey. 1982. Adherence of slime-producing strains of Staphylococcus epidermidis to smooth surfaces. Infect. Immun. 37:318-326.
10. Christensen, G. D., W. A. Simpson, A. L. Bisno, and E. H. Beachey. 1983. Experimental foreign body infections in mice challenged with slime-producing Staphylococcus epidermidis. Infect. Immun. 40:407-410.
11. Daher, K. A., M. E. Selsted, and R. I. Lehrer. 1986. Direct inactivation of viruses by human granulocyte defensins. J. Virol. 60:1068-1074.
12. Dougherty, S. H. 1988. Pathobiology of infection in prosthetic devices. Rev. Infect. Dis. 10:1102-1117.
13. Dougherty, S. H., and R. L. Simmons. 1982. Infections in bionic man: the pathobiology of infections in prosthetic devices - part I. Curr. Probl. Surg. 19:221-264.
14. Dougherty, S. H., and R. L. Simmons. 1989. Endogenous factors contributing to prosthetic device infections. Infect. Dis. Clin. N. Am. 3:199-209.
15. Falck, P. 1995. Characterization of human neutrophils adherent to organic polymers. Biomaterials 16:61-66.
16. Friedman, D. W., P. J. Orland, and R. S. Greco. 1994. Biomaterials: an historical perspective, p. 1-12. In R. S. Greco (ed.), Implantation biology: the host response and biomedical devices. CRC Press, Boca Raton, Fla.
17. Ganz, T. 1987. Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes. Infect. Immun. 55:568-571.
18. Ganz, T., and R. I. Lehrer. 1995. Defensins. Pharmacol. Ther. 66:191-205.
19. Ganz, T., M. E. Selsted, D. Szklarek, S. S. Harwig, K. Daher, D. F. Bainton, and R. I. Lehrer. 1985. Defensins: natural peptide antibiotics of human neutrophils. J. Clin. Investig. 76:1427-1435.
20. Gera, J. R., and A. Lichtenstein. 1991. Human neutrophil peptide defensins induce single strand DNA breaks in target cells. Cell. Immunol. 138:108-120.
21. Gormley, I. P., M. J. Kowolik, and R. T. Cullen. 1985 The chemiluminescent response of human phagocytic cells to mineral ducts. Br. J. Exp. Pathol. 66: 409-416.
22. Greco, R. S. 1997. Body parts: in vivo veritas. J. Biomed. Mater. Res. 34:409-410.
23. Gristina, A. G. 1987. Biomaterial centered infection: microbial adhesion versus tissue integration. Science 237:1588-1595.
24. Gristina, A. G., and J. W. Costerton. 1985. Bacterial adherence to biomaterials and tissue. J. Bone Joint Surg. 67:264-273.
25. Gristina, A. G., J. J. Dobbins, B. Giammara, J. C. Lewis, and W. C. DeVries. 1988. Biomaterial-centered sepsis and the total artificial heart - microbial adhesion versus tissue integration. J. Am. Med. Assoc. 259:870-874.
26. Guo, W. 1993. Infections associated with intraperitoneal biomaterials. Bulletin no. 92 of the Department of Surgery, Lund University, p. 9-12. Lund University, Lund, Sweden.
27. Hogt, A. H., J. Dankert, and J. Feijen. 1985. Adhesion of Staphylococcus epidermidis and Staphylococcus saprophyticus to a hydrophobic biomaterial. J. Gen. Microbiol. 131:2485-2491.
28. Hristova, K., M. E. Selsted, and S. H. White. 1997. Critical role of lipid composition in membrane permeabilization by rabbit neutrophil defensins. J. Biol. Chem. 272:24224-24333.
29. Hubbell, J. A. 1995. Biomaterials in tissue engineering. Bio/Technology 13: 565-576.
30. Hunt, J. A., B. F. Flanagan, P. J. McLaughlin, I. Strickland, and D. F. Williams. 1996. Effect of biomaterial surface charge on the inflammatory response: evaluation of cellular infiltration and TNF production. J. Biomed. Mater. Res. 31:139-144.
31. Johnson, G. M., D. A. Lee, W. E. Regelmann, E. D. Gray, G. Peters, and P. G. Quie. 1986. Interference with granulocyte function by Staphylococcus epidermidis slime. Infect. Immun. 54:13-20.
32. Kagan, B. L., T. Ganz, and R. I. Lehrer. 1994. Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology 87:131-149.
33. Kagan, B. L., M. E. Selsted, T. Ganz, and R. I. Lehrer. 1990. Neutrophil antimicrobial peptides (defensins) form voltage-dependent ionic channels in planar lipid bilayer membranes. Proc. Natl. Acad. Sci. USA 87:210-214.
34. Kaplan, S. S., R. E. Basford, M. H. Jeong, and R. L. Simmons. 1992. Biomaterial-induced alterations of neutrophil superoxide production. J. Biomed. Mater. Res. 26:1039-1051.
35. Kaplan, S. S., R. E. Basford, M. H. Jeong, and R. L. Simmons. 1994. Mechanisms of biomaterial-induced superoxide release by neutrophils. J. Biomed. Mater. Res. 28:377-386.
36. Kaplan, S. S., R. E. Basford, M. H. Jeong, and R. L. Simmons. 1996. Biomaterial-neutrophil interactions: dysregulation of oxidative functions of fresh neutrophils induced by prior neutrophil-biomaterial interaction. J. Biomed. Mater. Res. 30:67-75.
37. Kaplan, S. S., L. A. Caliguiri, R. E. Basford, and U. E. Zdziarski. 1987. Transient chemotactic defect in a child with elevated IgE. Ann. Allergy 59: 213-217.
38. Kaplan, S. S., and M. A. Nardi. 1977. Impairment of leukocyte function during sickle cell crisis. J. Reticuloendothel. Soc. 22:499-506.
39. Karlsson, C., H. Nygren, and M. Braide. 1996. Exposure of blood to biomaterial surfaces liberates substances that activate polymorphonuclear granulocytes. J. Lab. Clin. Med. 128:496-505.
40. Katz, D. A., and R. S. Greco. 1994 The pathobiology of infections associated with biomaterials. Probl. Gen. Surg. 1994(2):209-226.
41. Katz, D. A., B. Haimovich, and R. S. Greco. 1994. Neutrophil activation by expanded polytetrafluoroethylene is dependent on the induction of protein phosphorylation. Surgery 116:446-455.
42. Klock, J. C., and D. F. Bainton. 1976. Degranulation and abnormal bactericidal function of granulocytes procured by reversible adhesion to nylon wool. Blood 48:149-161.
43. 2 production and calcium release in human polymorphonuclear leukocytes. Blood 58:535-540.
44. Lehrer, R. I., A. Barton, K. A. Dahrer, S. S. L. Harwig, T. Ganz, and M. E. Selsted. 1989. Interaction of human defensins with Escherichia coli: mechanism of bactericidal activity. J. Clin. Investig. 84:553-561.
45. Lehrer, R. I., K. Daher, T. Ganz, and M. E. Selsted. 1985. Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes. J. Virol. 54:467-472.
46. Lehrer, R. I., and T. Ganz. 1990. Antimicrobial polypeptides of human neutrophils. Blood 76:2169-2181.
47. Lichtenstein, A. 1991. Mechanism of mammalian cell lysis mediated by peptide defensins. J. Clin. Investig. 88:93-100.
48. Lichtenstein, A., T. Ganz, M. E. Selsted, and R. I. Lehrer. 1986. In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood 68:1407-1410.
49. Lichtenstein, A. K., T. Ganz, T. M. Nguyen, M. E. Selsted, and R. I. Lehrer. 1988. Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity. J. Immunol. 140:2686-2694.
50. Lichtenstein, A. K., T. Ganz, M. E. Selsted, and R. I. Lehrer. 1988 Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins. Cell. Immunol. 114:104-116.
51. Malangoni, M. A., D. H. Livingston, and J. D. Peyton. 1993. The effect of protein binding on the adherence of staphylococci to prosthetic vascular grafts. J. Surg. Res. 54:168-172.
52. Marchant, R., A. Hiltner, C. Hamlin, A. Rabinovitch, and J. M. Anderson. 1983. In vivo biocompatibility studies. I. The cage implant system and a biodegradable hydrogel. J. Biomed. Mater. Res. 2:283-318.
53. Marchant, R., K. Miller, and J. M. Anderson. 1984. In vivo biocompatibility studies. V. In vivo leukocyte interactions with biomer. J. Biomed. Mater. Res. 18:1169-1190.
54. Miller, R. A., and B. E. Britigan. 1995, The formation and biologic significance of phagocyte-derived oxidants. J. Investig. Med. 43:39-49.
55. Panyutich, A. V., N. N. Voitenok, R. I. Lehrer, and T. Ganz. 1991. An enzyme immunoassay for human defensins. J. Immunol. Methods 141:149-155.
56. Peters, G., R. Locci, and G. Pulverer. 1982. Adherence and growth of coagulase-negative staphylococci on surfaces of intravenous catheters. J. Infect. Dis. 146:479-482.
57. Petty, W. 1978. The effect of methylmethacrylate on bacterial phagocytosis and killing by human polymorphonuclear leukocytes. J. Bone Joint Surg. 60A:752-757.
58. Ratner, B. D., A. B. Johnston, and T. J. Lenk. 1987. Biomaterial surface. J. Biomed. Mater. Res. 21(Suppl. A):59-87.
59. Salthouse, T. N. 1976. Cellular enzyme activity at the polymer-tissue interface: a review. J. Biomed. Mater. Res. 10:197-229.
60. Schwarzmann, S., and J. R. Boring. 1971. Antiphagocytic effect of slime from a mucoid strain of Pseudomonas aeruginosa. Infect. Immun. 3:762-766.
61. Selsted, M. E., D. Szklarek, T. Ganz, and R. I. Lehrer. 1985. Activity of rabbit leukocyte peptides against Candida albicans. Infect. Immun. 49:202-206.
62. Sengelov, H., P. Follin, L. Kjeldsen, K. Lollike, C. Dahlgren, and N. Borregaard. 1995. Mobilization of granules and secretory vesicles during in vivo exudation of human neutrophils. J. Immunol. 154:4157-4165.
63. Sengelov, H., L. Kjeldsen, and N. Borregaard. 1993. Control of exocytosis in early neutrophil activation. J. Immunol. 150:1535-1543.
64. Shanbhag, A., J. Yang, J. Lilien, and J. Black. 1992 Decreased neutrophil respiratory burst on exposure to cobalt-chrome alloy and polystyrene in vitro. J. Biomed. Mater. Res. 26:185-195.
65. Sheu, M. J., W. W. Baldwin, and K. W. Brunson. 1985. Cytotoxicity of rabbit macrophage peptides MCP-1 and MCP-2 for mouse tumor cells. Antimicrob. Agents Chemother. 28:626-629.
66. Sugarman, B., and E. J. Young. 1989. Infections associated with prosthetic devices: magnitude of the problem. Infect. Dis. Clin. N. Am. 3:187-198.
67. Tal, T., and I. Aviram. 1993. Defensin interferes with the activation of neutrophil NADPH oxides in a cell-free system. Biochem. Biophys. Res. Commun. 196:636-641.
68. Tal, T., M. Sharabani, and I. Aviram. 1998. Cationic proteins of neutrophil azurophilic granules: protein-protein interaction and blockade of NADPH oxidase activation. J. Leukoc. Biol. 63:305-311.
69. Wade, B. H., and G. L. Mandell. 1983. Polymorphonuclear leukocytes: dedicated professional phagocytes. Am. J. Med. 74:686-693.
70. Wang, I., J. M. Anderson, M. R. Jacobs, and R. E. Marchant. 1995. Adhesion of Staphylococcus epidermidis to biomedical polymers: contributions of surface thermodynamics and hemodynamic shear conditions. J. Biomed. Mater. Res. 29:485-493.
71. Wang, I., J. M. Anderson, and R. E. Marchant. 1993. Staphylococcus epidermidis adhesion to hydrophobic biomedical polymer is mediated by platelets. J. Infect. Dis. 167:329-336.
72. Wright, D. G., D. A. Bralove, and J. I. Gallin. 1977. The differential mobilization of human neutrophil granules. Effects of phorbol myristate acetate and ionophore A23187. Am. J. Pathol. 87:273-284.
73. Wright, D. G., and J. I. Gallin. 1979. Secretory responses of human neutrophils: exocytosis of specific (secondary) granules by human neutrophils during adherence in vitro and during exudation in vivo. J. Immunol. 123:285-294.
74. Yeaman, M. R., A. S. Bayer, S.-P. Koo, W. Foss, and P. M. Sullam. 1998. Platelet microbicidal proteins and neutrophil defensin disrupt the Staphylococcus aureus cytoplasmic membrane by distinct mechanisms of action. J. Clin. Investig. 101:178-187.
75. Yomugida, S., I. Nagaoka, K. Saito, and T. Yamashita. 1996. Evaluation of the effects of defensins on neutrophil functions. Inflamm. Res. 45:62-67.
76. Young, E. J., and B. Sugarman. 1988. Infections in prosthetic devices. Surg. Clin. N. Am. 68:167-180.
77. Ziats, N., K. Miller, and J. M. Anderson. 1988. In vitro and in vivo interactions of cells with biomaterials. Biomaterials 9:5-13.
78. Zimmerli, W., P. D. Lew, and F. A. Waldvogel. 1984. Pathogenesis of foreign body infection. Evidence for a local granulocyte defect. J. Clin. Investig. 73: 1191-1200.
79. Zimmerli, W., F. A. Waldvogel, P. Vandaux, and V. E. Nydegger. 1982. Pathogenesis of foreign body infection: description and characteristics of an animal model. J. Infect. Dis. 146:487-497.