Mitochondrial involvement in schizophrenia and other functional psychoses

Neurochemical Research

Volumn 21, Issue 9, 1996, Pages 995-1004

  Whatley, S A ^a   Curti, D ^b   Marchbanks, R M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

affective disorder; cytochrome oxidase; flupenthixol; gene expression; mitochondria; NADH cytochrome c reductase; psychosis; ribosomal RNA; Schizophrenia

Indexed keywords

CYTOCHROME C OXIDASE; FLUPENTIXOL; MITOCHONDRIAL RNA;

AFFECTIVE NEUROSIS; AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FRONTAL CORTEX; GENE EXPRESSION; HUMAN; MITOCHONDRION; PATHOGENESIS; PRIORITY JOURNAL; PSYCHOSIS; RNA ANALYSIS; SCHIZOPHRENIA;

ADULT; AGED; AGED, 80 AND OVER; AUTOPSY; DEPRESSIVE DISORDER; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX IV; FEMALE; FRONTAL LOBE; HUMANS; KINETICS; MALE; MIDDLE AGED; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PROTEIN BIOSYNTHESIS; REFERENCE VALUES; RNA, MESSENGER; SCHIZOPHRENIA; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0029848373     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02532409     Document Type: Article

References (33)

1. Crow, T. J., 1987 Psychosis as a continuum and the virogene concept. British Medical Bulletin, 43:754-767.
2. Johnstone, E. C., Crow, T. J., Frith, C. D., Carney, M. W. P. and Price, J. S., 1978 Mechanism of the antipsychotic in the treatment of acute schizophrenia. Lancet 1:848-851.
3. Coon, H., Byerley, W., Holik, J., Hoff, M., Myles-Worsley, M., Lannfelt, L., Sokoloff, P., Schwartz, J. C., Waldo, M., and Freedman, R, 1993 Linkage analysis of schizophrenia with five dopamine receptor genes in nine pedigrees. Am. J. Hum. Genet. 52: 327-334.
4. McGuffin P., Sargeant M., Hett G., Tidmarsh S., Whatley S. A. and Marchbanks R. M. 1990, Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11-q13 region:new data and a reanalysis of previous reports. Am. J. Hum. Genet. 47:524-535.
5. Mulcrone J., Whatley S. A., Marchbanks R. M., Wildenauer D., Altmark D., Daoud H., Gur E., Ebstein R. P., and Lerer B. 1995, Genetic linkage analysis of schizophrenia using chromosome llql3-24 markers in Israeli pedigrees. Am.J.Med.Genet. 60:103-108.
6. Perrett C. W., Marchbanks R. M., and Whatley S. A., 1988, Characterisation of messenger RNA extracted post-mortem from the brains of schizophrenic, depressed and control subjects, J.Neurol.Neurosurg.Psychiatr.51:325-331.
7. Perrett C. W., Whatley, S. A., Ferrier I. N., and Marchbanks R. M., 1992, Changes in relative levels of specific brain mRNA species associated with schizophrenia and depression. Mol. Brain. Res. 12:163-171.
8. Mulcrone J., and Whatley S. A. 1993, The application of differential cloning techniques in post-mortem studies of neuropsychiatric disorders: a way ahead. Psych. Med: 23,825-829.
9. Mulcrone, J., Whatley, S. A., Ferrier, I. N., and Marchbanks, R. M. 1995, A study of altered gene expression in frontal cortex from schizophrenic patients using differential screening. Schizophrenia Research 14:203-213.
10. Perrett, C., Owen, M., Marchbanks, R., and Whatley, S. 1992, The effect of chronic α- and β-flupenthixol treatment upon mRNA populations in the rat brain. Molecular Neuropharmacology, 2: 289-296.
11. Wharton D. C., and Tzagaloff A. 1967 Cytochrome oxidase from beef heart mitochondria. (Estabrook R. W. and Pullman (eds), Methods in Enzymology Vol. X, pages 245-246, Academic press, New York and London.
12. Seligman, A. M., Karnovsky, M. J., Waserkrug, H. L., and Hanker, J. S. 1968 Non droplet ultrastructural demonstration of cytochrome oxidase activity with a polymerising osmiophiolic reagent diaminobenzidine (DAB). J. Cell Biol, 38, 1-14.
13. +-linked isocitrate dehydrogenase glutamate dehydrogenase, aspartate aminotransferase in nervous tissue of vertebrates and invertebrates. Biochem. J., 150: 105-111.
14. Corral-Debrinski M., Horton T., Lott M. T., Schoffner J. M., Beal M. F., and Douglas C. W. 1992 Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nature Genetics 2:324-329.
15. Goff D. C., Henderson D. C., and Amico E. 1992 Cigarette smoking in schizophrenia relationship to psychopathology and medication side effects. Am J Psychiatry 149:1189-1194.
16. Brown M. D., Yang C-C, Trounce I., Torroni A., Lott M. T., and Wallace D. C. 1990 A mitochondrial DNA variant identified in Leber hereditary neuropathy patients which extends the amino acid sequence of cytochrome c oxidase subunit I. Am. J. Human Genetics, 46:428-433.
17. B binuclear site of bovine cytochrome c oxidase: new evidence for a redox linked conformational change at the binuclear site. Biochemistry 32:174-182.
18. Cavalier, L., Jazin, E, E., Erikson, I., Prince, J., Båve, J., Oreland, and Gyllensten U. 1995 Decreased cytochrome-c oxidase activity and lack of age related accumulation of mitochondrial DNA deletions in the brains of schizophrenics. Genomics, 229,217-224.
19. Chandrasekaran K., Giordano T., Brady D. R., Stoll J., Martin L. J., and Rapoport S. I. 1994 Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer's disease. Molecular Brain Res., 24:336-340.
20. Kish S. J., Bergeron C., Rajput A., Dozic S., Mastrogiacomo F., Chang L., Wilson J. M., DiStefano L. M., and Nobrega J. N. 1992 Brain cytochrome oxidase in Alzheimer's disease. J. Neurochem. 59:776-779
21. Mutisaya E. M., Bowling A. C., and Beal M. F. 1994 Cortical cytochrome oxidase activity is reduced in Alzheimer's disease J. Neurochem., 63:2179-2184.
22. Duara, R., Grady, C., and Haxby, I. 1986 Positron emission tomography in Alzheimer's disease. Neurology, 3:879-887.
23. Schapira A. H. V., Cooper J. M., Dexter D., Clark J. B., Jenner P., and Marsden C. D. 1990 Mitochondrial complex I deficiency in Parkinson's disease. J.Neurochem. 54:823-827
24. Takahashi, Y. 1954 An enzymological study on brain tissue of schizophrenic patients. Carbohydrate metabolism, Folia Psychiatrica Neurologia Japonica 7:214-237.
25. Cohen R. M., Semple W. E., Gross M, Nordahl T. E., Holcomb H. H., Dowling S., and Pickar D 1988 The effect of neuroleptics on dysfunction in a prefron substrate of sustained attention in schizophrenia. Life Sciences 43:1138-1150
26. Buchsbaum M. S, Neuchterlein K. H., Haier R. J., Wu J, Sicotte N, Hazlett E, Asarnow R, Potkin S., and Guich, S. 1990 Glucose metabolic rate in normals and schizophrenics during the continuous performance test assessed by Positron Emission Tomography. British J. Psychiatry 156:217-227.
27. Gold H. A., Henderson D. C., Clayton D. A., and Craft J 1989 The RNA processing enzyme RNase MRP is identical to the Th RNP and related to RNase P. Science 245:1377-1380.
28. Bonfa E., Golombek S. J., Kaufmann L. D., Skelly S., Weissbach H., Brot N., and Elkon H. B. 1987 Association between lupus psychosis and anti-ribosomal P protein antibodies. N. England J. Med. 317:265-271
29. Schneebaum, A. B., Singleton, J. D., West, S. G., Blodgett, J. K., Allen, Cheronis, J. C., and Kotzin, B. L. 1991 Association of psychiatric manifestations with antibodies to ribosomal P proteins in systemic lupus erythematosus. Am. J. Med., 90:564-62.
30. Goldstein J. M., Faraone S. V., Chen W. J., Tolmiczencko G. S., and Tsuang M. T. 1990 Sex differences in the familial transmission of schizophrenia. Br. J. Psych. 156:819-826.
31. Wolyneic P. S., Pulver A. E., McGrath J. A. and Tam D. 1992 Schizophrenia: Gender and familial risk. J. Psychiatr. Res. 1:17-27.
32. Schork, N. J., and Guo S-W 1993 Pedigree models for complex human traits involving the human genome. Am. J. Hum. Genet. 53:1320-1337.
33. Schacterle, G. B., and Pollack, R. I. 1973 A simplified method for the quantitation of small amounts of protein in biological materials. Anal. Biochem., 51:654-655