Cubilin, a multifunctional epithelial receptor: An overview

Journal of Molecular Medicine

Volumn 79, Issue 4, 2001, Pages 161-167

  Kozyraki, Renata ^a  

^a HÔPITAL SAINT ANTOINE   (France)

Author keywords

Cubilin; Endocytosis; High density lipoprotein; Megalin; Vitamin B12

Indexed keywords

CUBILIN; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MEGALIN;

HUMAN; HUMAN CELL; INTERNALIZATION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; REVIEW;

ANIMALS; EPITHELIAL CELLS; HUMANS; ILEUM; INTESTINAL MUCOSA; KIDNEY TUBULES, PROXIMAL; LIGANDS; LIPID METABOLISM; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, CELL SURFACE; YOLK SAC;

EID: 0035031562     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090100193     Document Type: Review

References (61)

1. Sahali D, Mulliez N, Chatelet F, Dupuis R, Ronco P, Verroust P (1988) Characterization of a 280-kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac. Teratogenic effect of the specific monoclonal antibodies. J Exp Med 167:213-218
2. Sahali D, Mulliez N, Chatelet F, Laurent-Winter C, Citadelle D, Roux C, Ronco P, Verroust P (1992) Coexpression in humans by kidney and fetal envelopes of a 280 kDa-coated pit-restricted protein. Similarity with the murine target of teratogenic antibodies. Am J Pathol 140:33-44
3. Seetharam B, Christensen EI, Moestrup SK, Hammond TG, Verroust PJ (1997) Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor. J Clin Invest 99:2317-2322
4. Saito A, Pietromonaco S, Loo AK, Farquhar MG (1994) Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci U S A 91:9725-9729
5. Seetharam B, Levine JS, Ramasamy M, Alpers DH (1988) Purification, properties, and immunochemical localization of a receptor for intrinsic factor-cobalamin complex in the rat kidney. J Biol Chem 263:4443-4449
6. Ramanujam KS, Seetharam S, Seetharam B (1993) Regulated expression of intrinsic factor-cobalamin receptor by rat visceral yolk sac and placental membranes. Biochim Biophys Acta 1146:243-246
7. Kozyraki R, Kristiansen M, Silahtaroglu A, Hansen C, Jacobsen C, Tommerup N, Verroust PJ, Moestrup SK (1998) The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region. Blood 91:3593-3600
8. Aminoff M, Carter JE, Chadwick RB, Johnson C, Grasbeck R, Abdelaal MA, Broch H, Jenner LB, Verroust PJ, Moestrup SK, de la Chapelle A, Krahe R (1999) Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1. Nat Genet 21:309-313
9. Kozyraki R, Fyfe J, Kristiansen M, Gerdes C, Jacobsen C, Cui S, Christensen EI, Aminoff M, de la Chapelle A, Krahe R, Verroust PJ, Moestrup SK (1999) The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein. Nat Med 5:656-661
10. Birn H, Fyfe JC, Jacobsen C, Mounier F, Verroust PJ, Orskov H, Willnow TE, Moestrup SK, Christensen EI (2000) Cubilin is an albumin binding protein important for renal tubular albumin reabsorption. J Clin Invest 105:1353-1361
11. Moestrup SK, Kozyraki R, Kristiansen M, Kaysen JH, Rasmussen HH, Brault D, Pontillon F, Goda FO, Christensen EI, Hammond TG, Verroust PJ (1998) The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. J Biol Chem 273:5235-5242
12. Xu D, Kozyraki R, Newman TC, Fyfe JC (1999) Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption. Blood 94:3604-3606
13. Romero A, Romao MJ, Varela PF, Kolln I, Dias JM, Carvalho AL, Sanz L, Topfer-Petersen E, Calvete JJ (1997) The crystal structures of two spermadhesins reveal the CUB domain fold. Nat Struct Biol 4:783-788
14. Varela PF, Romero A, Sanz L, Romao MJ, Topfer-Petersen E, Calvete JJ (1997) The 2.4A resolution crystal structure of boar seminal plasma PSP-I/PSP-II: a zona pellucida-binding glycoprotein heterodimer of the spermadhesin family built by a CUB domain architecture. J Mol Biol 274:635-649
15. Le Panse S, Ayani E, Nielsen S, Ronco P, Verroust P, Christensen EI (1997) Internalization and recycling of glycoprotein 280 in epithelial cells of yolk sac. Eur J Cell Biol 72:257-267
16. Le Panse S, Verroust P, Christensen EI (1997) Internalization and recycling of glycoprotein 280 in BN/MSV yolk sac epithelial cells: a model system of relevance to receptor-mediated endocytosis in the renal proximal tubule. Exp Nephrol 5:375-383
17. Birn H, Verroust PJ, Nexo E, Hager H, Jacobsen C, Christensen EI, Moestrup SK (1997) Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein. J Biol Chem 272:26497-26504
18. Kristiansen M, Kozyraki R, Jacobsen C, Nexo E, Verroust PJ, Moestrup SK (1999) Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding. J Biol Chem 274:20540-20544
19. Christensen EI, Birn H, Verroust P, Moestrup SK (1998) Membrane receptors for endocytosis in renal proximal tubule. Int Rev Cytol 180:237-284
20. Baricault L, Galceran M, Ronco PM, Trugnan G, Verroust PJ (1995) Unusual processing of GP280, a protein associated with the intermicrovillar areas of yolk sac epithelial cells: plasma membrane delivery of immature protein. Biochem Biophys Res Commun 212:353-359
21. Birn H, Vorum H, Verroust PJ, Moestrup SK, Christensen EI (1999) Receptor associated protein is important for normal processing of megalin in kidney proximal tubules. J Am Soc Nephrol 11:191-202
22. Le Panse S, Galceran M, Pontillon F, Lelongt B, van de Putte M, Ronco PM, Verroust PJ (1995) Immunofunctional properties of a yolk sac epithelial cell line expressing two proteins gp280 and gp330 of the intermicrovillar area of proximal tubule cells: inhibition of endocytosis by the specific antibodies. Eur J Cell Biol 67:120-129
23. Grasbeck R (1997) Selective cobalamin malabsorption and the cobalamin-intrinsic factor receptor. Acta Biochim Pol 44:725-734
24. Seetharam B, Bose S, Li N (1999) Cellular import of cobalamin (vitamin B-12). J Nutr 129:1761-1764
25. Idriss JM, Jonas AJ (1998) Vitamin B12 transport by rat liver lysosomal membrane vesicles. J Biol Chem 266:9438-9441
26. Fyfe JC, Ramanujam KS, Ramaswamy K, Patterson DF, Seetharam B (1991) Defective brush-border expression of intrinsic factor-cobalamin receptor in canine inherited intestinal cobalamin malabsorption. J Biol Chem 266:4489-4494
27. Kristiansen M, Aminoff M, Jacobsen C, Krahe R, de la Chapelle A, Verroust P, Moestrup SK (2000) The cubilin P1297L mutation associated with hereditary megaloblastic anaemia 1 (MGA1) causes impaired recognition of intrinsic factor-vitamin B12 by cubilin. Blood 96:405-409
28. Cui S, Verroust PJ, Moestrup SK, Christensen EI (1996) Megalin/gp330 mediates uptake of albumin in renal proximal tubule. Am J Physiol 271:F900-F9007
29. Zhai XY, Nielsen R, Birn H, Moestrup SK, Verroust PJ, Christensen, E I, Gekle M (2000) Cubilin and megalin mediated uptake of albumin in cultured proximal tubule cells of opossum kidney. Kidney Int 58:153-1533
30. Christensen EI, Kozyraki R, Dautry-Varsat A, Fyfe JC, Willnow TE, Verroust PJ, Moestrup SK (2000) Cubilin mediated, megalin assisted accumulation of transferrin in proximal tubule. J Am Soc Nephrol 11:49A
31. Remuzzi G, Bertani T (1998) Pathophysiology of progressive nephropathies. N Engl J Med 339:1448-1456
32. Zoja C, Benigni A, Remuzzi G (1999) Protein overload activates proximal tubular cells to release vasoactive and inflammatory mediators. Exp Nephrol 7:420-428
33. Neverov NI, Kaysen GA, Nuccitelli R, Weiss RH (1997) HDL causes mesangial cell mitogenesis through a tyrosine kinase-dependent receptor mechanism. J Am Soc Nephrol 8:1247-1256
34. Sahali D, Mulliez N, Chatelet F, Laurent-Winter C, Citadelle D, Sabourin JC, Roux C, Ronco P, Verroust P (1993) Comparative immunochemistry and ontogeny of two closely related coated pit proteins. The 280-kd target of teratogenic antibodies and the 330-kd target of nephritogenic antibodies. Am J Pathol 142:1654-1667
35. Lloyd JB (1990) Cell physiology of the rat visceral yolk sac: a study of pinocytosis and lysosome function. Teratology 41:383-393
36. Farese RV Jr, Herz J (1998) Cholesterol metabolism and embryogenesis. Trends Genet 14:115-120
37. Terasawa Y, Cases SJ, Wong JS, Jamil H, Jothi S, Traber MG, Packer L, Gordon DA, Hamilton RL, Farese RV Jr (1999) Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development. J Lipid Res 40:1967-1977
38. Lloyd JB, Brent RL, Beckman DA (1996) Sources of amino acids for protein synthesis during early organogenesis in the rat. III. Methionine incorporation. Placenta 17:629-634
39. Beckman DA, Lloyd JB, Brent RL (1998) Quantitative studies on the mechanisms of amino acid supply to rat embryos during organogenesis. Reprod Toxicol 12:197-200
40. Lloyd JB, Beckman DA, Brent RL (1998) Nutritional role of the visceral yolk sac in organogenesis-stage rat embryos. Reprod Toxicol 12:193-195
41. Herz J, Willnow TE, Farese RV Jr (1997) Cholesterol, hedge-hog and embryogenesis. Nat Genet 15:123-124
42. Roux C, Wolf C, Mulliez N, Gaoua W, Cormier V, Chevy F, Citadelle D (2000) Role of cholesterol in embryonic development. Am J Clin Nutr 71:1270S-1279S
43. Gaoua W, Wolf C, Chevy F, Ilien F, Roux C (2000) Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz syndrome animal model. J Lipid Res 41:637-646
44. Nanni L, Schelper RL, Muenke MT (2000) Molecular genetics of holoprosencephaly. Front Biosci 5:D334-D342
45. Wyne KL, Woollett LA (1998) Transport of maternal LDL and HDL to the fetal membranes and placenta of the Golden Syrian hamster is mediated by receptor-dependent and receptor-independent processes. J Lipid Res 39:518-530
46. Krieger M (1999) Charting the fate of the "good cholesterol": identification and characterization of the high-density lipoprotein receptor SR-BI. Annu Rev Biochem 68:523-558
47. Le Panse S, Ayani E, Mulliez N, Chatelet F, Cywiner-Golenzer C, Galceran M, Citadelle D, Roux C, Ronco P, Verroust P (1994) Antibodies to the 280-kd coated pit protein, target of teratogenic antibodies, produce alterations in the traffic of internalized proteins. Am J Pathol 145:1526-1536
48. Lafond J, Charest MC, Alain JF, Brissette L, Masse A, Robidoux J, Simoneau L (1999) Presence of CLA-1 and HDL binding sites on syncytiotrophoblast brush border and basal plasma membranes of human placenta. Placenta 20:583-590
49. Silver DL, Jiang XC, Arai T, Bruce C, Tall AR (2000) Receptors and lipid transfer proteins in HDL metabolism. Ann N Y Acad Sci 902:103-111
50. Glass CK, Pittman RC, Keller GA, Steinberg D (1983) Tissue sites of degradation of apoprotein A-I in the rat. J Biol Chem 258:7161-7167
51. Glass C, Pittman RC, Weinstein DB, Steinberg D (1983) Dissociation of tissue uptake of cholesterol ester from that of apoprotein A-I of rat plasma high density lipoprotein: selective delivery of cholesterol ester to liver, adrenal, and gonad. Proc Natl Acad Sci U S A 80:5435-5439
52. Braschi S, Neville TA, Maugeais C, Ramsamy TA, Seymour R, Sparks DL (2000) Role of the kidney in regulating the metabolism of HDL in rabbits: evidence that iodination alters the catabolism of apolipoprotein A-I by the kidney. Biochemistry 39:5441-5449
53. Bohrer MP, Baylis C, Humes HD, Glassock RJ, Robertson CR, Brenner BM (1978) Permselectivity of the glomerular capillary wall. Facilitated filtration of circulating polycations. J Clin Invest 61:72-78
54. Braschi S, Neville TA, Vohl MC, Sparks DL (1999) Apolipoprotein A-I charge and conformation regulate the clearance of reconstituted high density lipoprotein in vivo. J Lipid Res 40:522-532
55. Bruce C, Chouinard RA Jr, Tall AR (1998) Plasma lipid transfer proteins, high-density lipoproteins, and reverse cholesterol transport. Annu Rev Nutr 18:297-330
56. Weng W, Breslow JL (1996) Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility. Proc Natl Acad Sci USA 93:14788-14794
57. Lambert G, Amar MJ, Martin P, Fruchart-Najib J, Foger B, Shamburek RD, Brewer HB Jr, Santamarina-Fojo S (2000) Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo. J Lipid Res 41:667-672
58. Jaye M, Lynch KJ, Krawiec J, Marchadier D, Maugeais C, Doan K, South V, Amin D, Perrone M, Rader DJ (1999) A novel endothelial-derived lipase that modulates HDL metabolism. Nat Genet 21:424-428
59. Ueda Y, Royer L, Gong E, Zhang J, Cooper PN, Francone O, Rubin EM (1999) Lower plasma levels and accelerated clearance of high density lipoprotein (HDL) and non-HDL cholesterol in scavenger receptor class B type I transgenic mice. J Biol Chem 274:7165-7171
60. Chatelet F, Cywiner C, Pastier D, Tran Quang N, Chambaz J, Verroust P, Kalopissis A (2000) Increased renal catabolism of endogenous apoA-I in transgenic mice overexpressing human apoA-II. Atherosclerosis 151[1], 174
61. Brooks-Wilson A, Marcil M, Clee SM, Zhang LH, Roomp K, van Dam M, Yu L, Brewer C, Collins JA, Molhuizen HO, Loubser O, Ouelette BF, Fichter K, Ashbourne-Excoffon KJ, Sensen CW, Scherer S, Mott S, Denis M, Martindale D, Frohlich J, Morgan K, Koop B, Pimstone S, Kastelein JJ, Hayden MR (1999) Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet 22:336-345