Hypoxia-stimulated expression of angiogenic growth factors in cervical cancer cells and cervical cancer-derived fibroblasts

International Journal of Gynecological Cancer

Volumn 11, Issue 2, 2001, Pages 137-142

  Pilch, H ^a   Schlenger, K ^a   Steiner, E ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Angiogenesis; Cervical carcinoma; Fibroblasts; Tumor stroma

Indexed keywords

ANGIOGENIC FACTOR; ANGIOGENIN; GROWTH FACTOR; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CANCER CELL; CANCER GROWTH; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; METASTASIS; PRIORITY JOURNAL; PROTEIN SECRETION; STROMA CELL; UTERINE CERVIX CANCER;

ANOXIA; CELL DIVISION; ENDOTHELIAL GROWTH FACTORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; KINETICS; LYMPHOKINES; NEOVASCULARIZATION, PATHOLOGIC; RIBONUCLEASE, PANCREATIC; UTERINE CERVICAL NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035027615     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1438.2001.011002137.x     Document Type: Article

References (37)

1. Angiogenesis and metastasis
2. Tumoral vascularity as a prognostic factor in cancer
3. Angiogenesis in malignancies of the female genital tract
4. Blood flow, oxygen and nutrient supply, and metabolite microenvironment of human tumors: A review
5. Intratumoral pO2 predicts surivival in advanced cancer of the uterine cervix
6. Oxygenation predicts radiation response and survival in patients with cervix cancer
7. Intratumoral pO (2) -measurements as predictive assay in the treatment of carcinoma of the uterine cervix
8. Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: Relationships to pre-treatment tumor oxygeneration and vascularization
9. Quantitative RTPCR assay detecting the transcriptional induction of vascular endothelial growth factor under hypoxia
10. Secretion rates and levels of vascular endothelial growth factor in clone A or HCT-8 human colon tumor cells as function of oxygen concentration
11. A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines
12. Candidate genes for the hypoxic tumor phenotype
13. Hypoxia-induced up-regulation of angiogenin in human malignant melanoma
14. Hypoxia-induced release of peptide growth factors from neonatal porcine pulmonary artery smooth muscle cells
15. Human endothelium as a source of multifunctional cytokines: Molecular regulation and possible role in human disease
16. Adaptive responses of the endothelium to stress
17. Regulation of macrophage production of vascular endothelial growth factor (VEGF) by hypoxia and transforming growth factor beta-1
18. Production of vascular endothelial growth factor by murine macrophages. Regulation by hypoxia, lactate, and the inducible nitric oxide synthase pathway
19. Macrophage responses to hypoxia: Relevance to disease mechanisms
20. Hypoxia upregulates the synthesis of TGF-beta 1 by human dermal fibroblasts
21. Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression
22. Expression of vascular endothelial growth factor in synovial fibroblasts is induced by hypoxia and interleukin 1beta
23. Tumor induction of VEGF promoter activity in stromal cells
24. Hypoxia up-regulates VEGF production in keloid fibroblasts
25. Fibroblast response to hypoxia: The relationship between angiogenesis and matrix regulation
26. Pericellular PO2 and O2 consumption in monolayer cell cultures
27. 3-D coculture of hepatic sinusoidal cells with primary hepatocytes-design of an organotypical model
28. Cell inactivation and cell cycle inhibition as induced by extreme hypoxia: The possible role of cell cycle arrest as a protection against hypoxia-induced lethal damage
29. Circulating serum levels of cytokines and angiogenic factors in patients with cervical cancer
30. Angiogenesis is associated with vascular endothelial growth factor expression in cervical intraepithelial neoplasia
31. Expression of vascular endothelial growth factor (VEGF) and its mRNA in uterine cervical cancers
32. Different angiogenic pathways in human cervical cancers
33. Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as hypoxic marker
34. Immunohistochemical expression of growth factors in subacute thyroiditis and their effects on thyroid folliculogenesis and angiogenesis in collagen gel matrix culture
35. Expression of vascular endothelial growth factor (VEGF) and its two receptors (VEGF-R1-Flt1 and VEGF-R2-Flk1/KDR) in non-small cell lung carcinomas (NSCLCs): Correlation with angiogenesis and survival
36. Expression and regulation of vascular endothelial growth factor in choroidal fibroblasts