Hypoxia upregulates VEGF production in keloid febroblasts

Annals of Plastic Surgery

Volumn 42, Issue 5, 1999, Pages 514-520

  Steinbrech, Douglas S ^a   Mehrara, Babak J ^a   Chau, Dorothy ^a   Rowe, Norman M ^a   Chin, Gyu ^a   Lee, Tom ^a   Saadeh, Pierre B ^a   Gittes, George K ^a   Longaker, Michael T ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; CYTOKINE; VASCULOTROPIN;

ARTICLE; BLOOD VESSEL OCCLUSION; CELL CULTURE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; HUMAN; HUMAN CELL; HYPOXIA; KELOID; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RECEPTOR UPREGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WOUND HEALING;

EID: 0032891017     PISSN: 01487043     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000637-199905000-00009     Document Type: Article

References (41)

1. Murray JC. Scars and keloids. Dermatol Clin 1993;11(4): 697-708
2. Nemeth AJ. Keloids and hypertrophic scars. J Dermatol Surg Oncol 1993;19(8):738-746
3. Datubo-Brown DD. Keloids: a review of the literature. Br J Plast Surg 1990;43(1):70-77
4. Kischer CW, Shetlar MR, Chvapil M. Hypertrophic scars and keloids: a review and new concept concerning their origin. Scanning Electron Microsc 1982;(Pt 4):1699-1713
5. Kischer CW, Thies AC, Chvapil M. Perivascular myofibroblasts and microvascular occlusion in hypertrophic scars and keloids. Hum Pathol 1982;13(9):819-824
6. Leung DW, Cachianes G, Kuang WJ, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246(4935):1306-1309
7. Keck PJ, Hauser SD, Krivi G, et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989;246(4935):1309-1312
8. Gospodarowicz D, Lau K. Pituitary follicular cells secrete both vascular endothelial growth factor and follistatin. Biochem Biophys Res Commun 1989;165(1):292-298
9. Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989; 161(2):851-858
10. Conn G, Bayne ML, Soderman DD, et al. Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc Natl Acad Sci U S A 1990;87(7):2628-2632
11. Connolly DT, Heuvelman DM, Nelson R, et al. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 1989;84(5):1470-1478
12. Namiki A, Brogi E, Kearney M, et al. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J Biol Chem 1995;270(52):31189-31195
13. Minchenko A, Bauer T, Saleda S, Caro J. Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo. Lab Invest 1994;71(3):374-379
14. Detmar M, Yeo KT, Nagy JA, et al. Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells. J Invest Dermatol 1995;105(1):44-50
15. Sandner P, Wolf K, Bergmaier U, et al. Induction of VEGF and VEGF receptor gene expression by hypoxia: divergent regulation in vivo and in vitro. Kidney Int 1997;51(2): 448-453
16. Gorden DL, Mandriota SJ, Montesano R, et al. Vascular endothelial growth factor is increased in devascularized rat islets of Langerhans in vitro. Transplantation 1997; 63(3):436-443
17. Hunt TK. Prospective: a retrospective perspective on the nature of wounds. Prog Clin Biol Res 1988;266:13-20
18. Knighton DR, Silver IA, Hunt TK. Regulation of wound-healing angiogenesis - effect of oxygen gradients and inspired oxygen concentration. Surgery 1981;90(2):262-270
19. Knighton DR, Fiegel VD. Regulation of cutaneous wound healing by growth factors and the microenvironment. Invest Radiol 1991;26(6):604-611
20. Kueng W, Silber E, Eppenberger U. Quantification of cells cultured on 96-well plates. Anal Biochem 1989;182:16-19
21. Anderson G, Volpe C, Russo C, et al. The anoxic fibroblast response is an early-stage wound healing program. J Surg Res 1995;59:666-674
22. Shima D, Deutsch U, D'Amore P. Hypoxia induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability. FEBS Lett 1995;370(3):203-208
23. Thomas KA. Vascular endothelial growth factor, a potent and selective angiogenic agent. J Biol Chem 1996;271(2): 603-606
24. Brown LF, Yeo K, Berse B, et al. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 1992;176:1375-1379
25. Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996;380(6573):435-439
26. Ferrara N, Carver-Moore K, Chen H, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996;380(6573):439-442
27. Enholm B, Paavonen K, Ristimaki A, et al. Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia. Oncogene 1997;14:2475-2483
28. Frank S, Hubner G, Breier G, et al. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem 1995;270(21):12607-12613
29. Kvanta A. Expression and regulation of vascular endothelial growth factor in choroidal fibroblasts. Curr Eye Res 1995;14(11):1015-1020
30. Detmar M, Brown LF, Berse B, et al. Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin. J Invest Dermatol 1997;108(3):263-268
31. Stein I, Neeman M, Shweiki D, et al. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol 1995;15(10):5363-5368
32. Brogi E, Schatteman G, Wu T, et al. Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression. J Clin Invest 1996;97(2):469-476
33. Waltenberger J, Mayr U, Pentz S, Hombach V. Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia. Circulation 1996;94(7):1647-1654
34. Knighton DR, Hunt TK, Scheuenstuhl H, et al. Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science 1983;221(4617):1283-1285
35. Orphanides C, Fine LG, Norman JT. Hypoxia stimulates proximal tubular cell matrix production via a TGF-beta1-independent mechanism. Kidney Int 1997;52(3): 637-647
36. Agocha A, Lee HW, Eghbali-Webb M. Hypoxia regulates basal and induced DNA synthesis and collagen type I production in human cardiac fibroblasts: effects of transforming growth factor-beta 1, thyroid hormone, angiotensin II and basic fibroblast growth factor. J Mol Cell Cardiol 1997;29(8):2233-2244
37. Kischer CW. The microvessels in hypertrophic scars, keloids and related lesions: a review. J Submicrosc Cytol Pathol 1992;24(2):281-296
38. O'Toole EA, Marinkovich MP, Peavey CL, et al. Hypoxia increases human keratinocyte motility on connective tissue. J Clin Invest 1997;100(11):2881-2891
39. Dawes KE, Peacock AJ, Gray AJ, et al. Characterization of fibroblast mitogens and chemoattractants produced by endothelial cells exposed to hypoxia. Am J Respir Cell Mol Biol 1994;10(5):552-559
40. Mesri E, Federoff H, Brownlee M. Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice. Circ Res 1995;76(2):161-167
41. Smyth AP, Rook SL, Detmar M, Robinson GS. Antisense oligonucleotides inhibit vascular endothelial growth factor/vascular permeability factor expression in normal human epidermal keratinocytes. J Invest Dermatol 1997; 108(4):523-526