Telomerase activity in relation to pro- and anti-apoptotic protein expression in high grade non-hodgkin's lymphomas

Haematologica

Volumn 86, Issue 4, 2001, Pages 386-393

  MacNamara, B ^a   Xu, D ^a   Wang, W ^a   Chen, Z ^a   Hou, M ^a   Mazur, J ^a   Gruber, A ^a   Porwit MacDonald, A ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apoptosis; BCL 2; Lymphoma; p53; Proliferation; Telomerase

Indexed keywords

KI 67 ANTIGEN; MESSENGER RNA; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; PROTEIN P53; RNA DIRECTED DNA POLYMERASE; TANKYRASE; TELOMERASE;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER CLASSIFICATION; CANCER GRADING; CANCER SURVIVAL; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; ENZYME ACTIVITY; FEMALE; GENE AMPLIFICATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NICK END LABELING; NONHODGKIN LYMPHOMA; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; FEMALE; FROZEN SECTIONS; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOMA, NON-HODGKIN; MALE; MIDDLE AGED; PROTEINS; TELOMERASE;

EID: 0035023889     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Telomerase activity, cell proliferation, and cancer
2. Role of telomerase in cellular proliferation and cancer
3. Telomere length predicts replicative capacity of human fibroblasts
4. Structure and function of telomeres
5. Telomeres shorten during ageing of human fibroblasts
6. Specific association of human telomerase activity with immortal cells and cancer
7. Telomerases
8. Telomerase in human development and cancer
9. Telomere length and telomerase activity in malignant lymphomas at diagnosis and relapse
10. Telomerase activity in central nervous system malignant lymphoma
11. The RNA component of human telomerase
12. hEST2, the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization
13. Telomerase catalytic subunit homologs from fission yeast and humans
14. Extension of life-span by introduction of telomerase into normal human cells
15. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
16. Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro
17. Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells
18. High-grade malignant non-Hodgkin's lymphomas differ from low-grade lymphomas in the extent of apoptosis and their expression of bcl-2, mcl-1, BAX and p53
19. p53 gene mutations and rearrangements in non-Hodgkin's lymphoma
20. Mutations of the p53 gene as a prognostic factor in aggressive B-cell lymphoma
21. Telomerase activity in B-cell non-Hodgkin lymphoma
22. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
23. Tankyrase promotes telomere elongation in human cells
24. Telomerase activity in multiple myeloma
25. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
26. Bcl-2 expression and glucocorticoid-induced apoptosis of leukemic and lymphoma cells
27. Bcl-2 family proteins: Regulators of apoptosis and chemoresistance in hematologic malignancies
28. Bcl-2 modulates telomerase activity
29. Anti-apoptotic role of telomerase in pheochromocytoma cells
30. Telomerase activity in neuroblastoma: Is it a prognostic indicator of clinical behaviour?
31. Telomerase activity in gastric cancer
32. Telomerase activity in relation to p53 status and clinico-pathological parameters in breast cancer
33. Telomerase activity in ordinary meningiomas predicts poor outcome
34. Telomerase activity in chronic lymphoproliferative disorders of B-cell lineage
35. Frequent amplification of the telomerase reverse transcriptase gene in human tumors
36. Telomerase activity and the expression of telomerase components in acute myelogenous leukaemia
37. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group
38. International conference on leukemia-lymphoma. Ann Arbor, Michigan, October, 1967
39. CHOP-firstline treatment in NHL with unfavorable prognosis: Evaluation of therapeutic response and factors influencing prognosis
40. Prognostic significance of proliferative and apoptotic fractions in low grade follicle center cell-derived non-Hodgkin's lymphomas
41. DNA content and expression of PCNA and p53 in Hodgkin's disease and Hodgkin's-like B-cell lymphoma
42. Telomerase activity and telomere length in lymphocytes from patients with cutaneous T-cell lymphoma
43. Telomerase activity in reactive and neoplastic lymphoid tissues: Infrequent detection of activity in Hodgkin's disease
44. Telomerase activation in normal B lymphocytes and non-Hodgkin's lymphomas
45. Expression of TERT in early premalignant lesions and a subset of cells in normal tissues
46. Expression of human telomerase subunits in ovarian malignant, borderline and benign tumors
47. Upregulation of telomerase activity by X-irradiation in mouse leukaemia cells is independent of Tert, Terc, Tnks and Myc transcription
48. Telomerase activity by TRAP assay and telomerase RNA (hTR) expression are predictive of outcome in neuroblastoma
49. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types
50. Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes
51. Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription
52. Telomerase activity and Bcl-2 expression in non-small cell lung cancer
53. Life and death in the genesis of the tumour cell
54. Resistance to apoptosis in human cells conferred by telomerase function and telomere stability
55. Telomerase activity is not related to apoptosis in leukemic cell lines
56. Correlations between apoptotic and proliferative indices in malignant non-Hodgkin's lymphomas
57. Prognostic relevance of apoptotic cell death in non-Hodgkin's lymphomas: A multivariate survival analysis including Ki67 and p53 oncoprotein expression
58. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase
59. Telomerase activity significantly correlates with chromosome alterations, cell differentiation, and proliferation in lung adenocarcinomas
60. Telomerase activity significantly correlates with cell differentiation, proliferation and lymph node metastasis in colorectal carcinomas
61. High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer
62. Telomere length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukemia