Tolerant B lymphocytes acquire resistance to Fas-mediated apoptosis after treatment with interleukin 4 but not after treatment with specific antigen unless a surface immunoglobulin threshold is exceeded

Journal of Experimental Medicine

Volumn 187, Issue 6, 1998, Pages 847-853

  Foote, Linda C ^a,d   Marshak Rothstein, Ann ^a   Rothstein, Thomas L ^a,b,c  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOSTON MEDICAL CENTER   (United States)

^d MERRIMACK COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; FAS ANTIGEN; INTERLEUKIN 4; LYMPHOCYTE ANTIGEN RECEPTOR; STREPTAVIDIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BIOTINYLATION; CONTROLLED STUDY; FLUORESCENCE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; B-LYMPHOCYTES; CD40 LIGAND; IMMUNE TOLERANCE; INTERLEUKIN-4; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MURAMIDASE; RECEPTORS, ANTIGEN, B-CELL;

EID: 0032536832     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.6.847     Document Type: Article

References (35)

1. Owen-Schaub, L.B., S. Yonehara, W.L. Crump, and E.A. Grimm. 1992. DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cell. Immunol. 140:197-205.
2. 2+ -independent T cell-mediated cytotoxicity. J. Exp. Med. 177:195-200.
3. Stalder, T., S. Hahn, and P. Erb. 1994. Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity. J. Immunol. 152:1127-1133.
4. Ju, S.-T., H. Cui, D.J. Panka, R. Ettinger, and A. Marshak-Rothstein. 1994. Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells. Proc. Natl. Acad. Sci. USA. 91:4185-4189.
5. Hanabuchi, S., M. Koyanagi, A. Kawasaki, N. Shinohara, A. Matsuzawa, Y. Nishimura, S. Kobayashi, S. Yonehara, H. Yagita, and K. Okumura. 1994. Fas and its ligand in a general mechanism of T cell-mediated cytotoxicity. Proc. Natl. Acad. Sci. USA. 91:4930-4934.
6. Vignaux, F., E. Vivier, B. Malissen, V. Depraetere, S. Nagata, and P. Golstein. 1995. TCR/CD3 coupling to Fas-based cytotoxicity. J. Exp. Med. 181:781-786.
7. Henkart, P.A. 1994. Lymphocyte-mediated cytotoxicity: two pathways and multiple effector molecules. Immunity 1:343-346.
8. Rothstein, T.L., J.K.M. Wang, D.J. Panka, L.C. Foote, Z. Wang, B. Stanger, H. Cui, S.-T. Ju, and A. Marshak-Rothstein. 1995. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature. 374:163-165.
9. Garrone, P., E.-M. Neihardt, E. Garcia, L. Galibert, C. van Kooten, and J. Banchereau. 1995. Fas ligand induces apoptosis of CD40-activated human B lymphocytes. J. Exp. Med. 182:1265-1273.
10. Schattner, E.J., K.B. Elkon, D.-H. Yoo, J. Tumang, P.H. Krammer, M.C. Crow, and S.M. Friedman. 1995. CD40 ligation induces APO-1/Fas expression on human B lymphocytes and facilitates apoptosis through the APO-1/Fas pathway. J. Exp. Med. 182:1557-1565.
11. Foote, L.C., T.J. Schneider, G.M. Fischer, J.K.M. Wang, B. Rasmussen, K.M. Campbell, D.H. Lynch, S.-T. Ju, A. Marshak-Rothstein, and T.L. Rothstein. 1996. Intracellular signaling for inducible antigen receptor-mediated Fas resistance in B cells. J. Immunol. 157:1878-1885.
12. Lagresle, C., C. Mondiere, C. Bella, P.H. Krammer, and T. Defrance. 1996. Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis. J. Exp. Med. 183: 1377-1388.
13. Foote, L.C., R.G. Howard, A. Marshak-Rochstein, and T.L. Rothstein. 1996. IL-4 induces Fas resistance in B cells. J. Immunol. 157:2749-2753.
14. L protects primary B cells against Fasmediated apoptosis. J. Immunol. 159:4834-4839.
15. Nemazee, D.A., and K. Burki. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature. 337:562-566.
16. Hartley, S.B., J. Crosbie, R. Brink, A.A. Kantor, A. Basten, and C.C. Goodnow. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature. 353:765-769.
17. Tiegs, S.L., D.M. Russell, and D. Nemazee. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1009-1020.
18. Prak, E.L., and M. Weigert. 1995. Light chain replacement: a new model for antibody gene rearrangement. J. Exp. Med. 182:541-548.
19. Eris, J.M., A. Basten, R. Brink, K. Doherty, M.R. Kehry, and P.D. Hodgkin. 1994. Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T cell signals but are defective in antigen-receptor-mediated functions. Proc. Natl. Acad. Sci. USA. 92:99-105.
20. Cooke, M.P., A.W. Heath, K.M. Shokat, Y. Zeng, F.D. Finkleman, P.S. Linsley, M. Howard, and C.C Goodnow. 1994. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J. Exp. Med. 179:425-438.
21. Goodnow, C.C. 1996. Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc. Natl. Acad. Sci. USA. 93:2264-2271.
22. Izui, S., V.E. Kelley, K. Masuda, H. Yoshida, J.B. Roths, and E.D. Murphy. 1984. Induction of varioous autoantibodies by mutant gene lpr in several strains of mice. J. Immunol. 133: 227-233.
23. Adachi, M., S. Suematsu, T. Suda, D. Watanabe, H. Fukuyama, J. Ogasawara, T. Tanaka, N. Yoshida, and S. Nagata. 1996. Enhanced and accelerated lymphoproliferation in Fasnull mice. Proc. Natl. Acad. Sci. USA. 93:2131-2136.
24. Rathmell, J.C., M.P. Cooke, W.Y. Ho, J. Grein, S.E. Townsend, M.M. Davis, and C.C. Goodnow. 1995. CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Nature. 376:181-184.
25. Rathmell, J.C., S.E. Townsend, J.C. Xu, R.A. Flavell, and C.C. Goodnow. 1996. Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. Cell. 87:319-329.
26. Chen, S., and G.A. Evans. 1990. A simple screening method for transgenic mice using the polymerase chain reaction. Biotechniques. 8:32-33.
27. Lane, P., T. Brocker, S. Hubele, E. Padovan, A. Lanzavecchia, and F. McConnell. 1993. Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation. J. Exp. Med. 177:1209-1213.
28. Francis, D.A., J.G. Karras, X.-Y. Ke, R. Sen, and T.L. Rothstein. 1995. Induction of the transcription factor NF-κB, AP-1, and NF-AT during B cell stimulation through the CD40 receptor. Int. Immunol 7:151-161.
29. Brunswick, M., F.D. Finkelman, P.F. Highet, J.K. Inman, H.M. Dintzis, and J.J. Mond. 1988. Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation. J. Immunol. 140:3364-3372.
30. Goodnow, C.C., J. Crosbie, S. Adelstein, T.D. Lavoie, S.J. Smith-Gill, R.A. Brink, H. Pritchard-Briscoe, J.S. Wotherspoon, R.H. Loblay, K. Raphael, et al. 1988. Altered immunoglobulin expression and functional silencing of sell-reactive B lymphocytes in transgenic mice. Nature. 334:676-682.
31. Goodnow, C.C., J. Crosbie, H. Jorgensen, R.A. Brink, and A. Basten. 1989. Induction of self tolerance in mature peripheral B lymphocytes. Nature. 342:385-391.
32. DiPiro, J.T., T.R. Howdieshell, J.K. Goddard, D.B. Callaway, R.G. Hamilton, and A.R. Mansberger, Jr. 1995 Association of interleukin-4 plasma levels with traumatic injury and clinical course. Arch. Surg. 130:1159-1162.
33. 2-terminal amino acid sequences of the heavy and light chains of human monoclonal lupus autoantibodies containing the dominant 16/6 idiotype. J. Clin. Invest. 75:1138-1143.
34. Carroll, P., D. Stafford, R.S. Schwartz, and B.D. Stollar. 1985. Murine monoclonal anti-DNA autoantibodies bind to endogenous bacteria. J. Immunol. 135:1086-1090.
35. Duggan, D.B., C. Mackworth-Young, A. Kari-Lefvert, J. Andre-Schwartz, D. Mudd, K.P. McAdam, and R.S. Schwartz. 1988. Polyspecificity of human monoclonal antibodies reactive with Mycobacterium leprae, mitochondria, ssDNA, cytoskeletal proteins, amd the acetylcholine receptor. Clin. Immunol. Immunopathol. 49:327-340.