Disruption of positive selection of thymocytes causes autoimmunity

Nature Medicine

Volumn 6, Issue 3, 2000, Pages 298-305

  Kretz Rommel, Anke ^a   Rubin, Robert L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; HYDROXYLAMINE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2; PEPTIDE; PROCAINAMIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; FETUS; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, NEWBORN; ANTIGEN-PRESENTING CELLS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; COLUMBIDAE; CYTOCHROME C GROUP; IMMUNE TOLERANCE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, INBRED STRAINS; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; ORGAN CULTURE TECHNIQUES; PEPTIDE FRAGMENTS; PROCAINAMIDE; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; THYMUS GLAND;

ANIMALIA;

EID: 0034020886     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/73152     Document Type: Article

References (56)

1. Hess, E.V. & Mongey, A.-B. Drug-related lupus. Bull. Rheum. Dis. 40, 1-8 (1991).
2. Yung, R.L. & Richardson, B.C. Drug-induced lupus. Rheum. Dis. Clin. North Am. 20, 61-86 (1994).
3. th edn. (eds. Wallace, D.J. & Hahn, B.H.) 871-901 (Williams and Wilkens, Baltimore, Maryland, 1997).
4. von Boehmer, H. Positive selection of lymphocytes. Cell 76, 219-228 (1994).
5. lc thymocytes in vivo. Science 250, 1720-1722 (1990).
6. Kappler, J.W., Roehm, N. & Marrack, P.C. T cell tolerance by clonal elimination in the thymus. Cell 149, 273-280 (1987).
7. + thymocytes. Nature 333, 742-746 (1988).
8. Vasquez, N.J., Kaye, J. & Hedrick, S.M. In vivo and in vitro clonal deletion of double-positive thymocytes. J. Exp. Med. 175, 1307-1316 (1992).
9. Rubin, R.L. & Kretz-Rommel, A. Linkage of immune self-tolerance with the positive selection of T cells. Crit. Rev. Immunol. 19, 199-218 (1999).
10. Kretz-Rommel, A., Duncan, S.R. & Rubin, R.L. Autoimmunity caused by disruption of central T cell tolerance: a murine model of drug-induced lupus. J. Clin. Invest. 99, 1888-1896 (1997).
11. Kretz-Rommel, A. & Rubin, R.L. Persistence of autoreactive T cell drive in required to elicit anti-chromatin antibodies in a murine model of drug-induced lupus. J. Immunol. 162, 813-820 (1999).
12. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341, 746-749 (1989).
13. Fink, P.J., Matis, L.A., McElligott, D.L., Bookman, M. & Hedrick, S.M. Correlations between T-cell specificity and the structure of the antigen receptor. Nature 321, 219-226 (1986).
14. Ogasawara, K., Maloy, W.L., Beverly, B. & Schwartz, R.H. Functional analysis of the antigenic structure of a minor T cell determinant from pigeon cytochrome C. Evidence against an alpha-helical conformation. J. Immunol. 142, 1448-1456 (1989).
15. Suzuki, G. & Schwartz, R.H. The pigeon cytochrome c-specific T cell response of low responder mice. I. Identification of antigenic determinants on fragment 1 to 65. J. Immunol. 136, 230-239 (1986).
16. Matechak, E.O., Killeen, N., Hedrick, S.M. & Fowlkes, B.J. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 4, 337-347 (1996).
17. Oehen, S., Feng, L., Xia, Y., Suhr, C.D. & Hedrick, S.M. Antigen compartmentation and T helper cell tolerance induction. J. Exp. Med. 183, 2617-2626 (1996).
18. Janeway, C.A. Selective elements for the Vβ region of the T cell receptor: Mls and the bacterial toxic mitogens. Adv. Immunol. 50, 1-53 (1991).
19. β-specific superantigen Staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56, 27-35 (1989).
20. Kaye, J. & Ellenberger, D.L. Differentiation of an immature T cell line: A model of thymic positive selection. Cell 71, 423-435 (1992).
21. Kishimoto, H. et al. Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes. J. Exp. Med. 184, 531-537 (1996).
22. Ohashi, P.S. T cell selection and autoimmunity: flexibility and tuning. Curr. Opinion Immunol. 8, 808-814 (1996).
23. Grossman, Z. & Singer, A. Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus. Proc. Natl. Acad. Sci. USA 93, 14747-14752 (1996).
24. Allen, P.M. Peptides in positive and negative selection: A delicate balance. Cell 76, 593-596 (1994).
25. Vasquez, N.J., Kane, L.P. & Hedrick, S.M. Intracellular signals that mediate thymic negative selection. Immunity 1, 45-56 (1994).
26. k peptide combination. J. Exp. Med. 186, 1441-1450 (1997).
27. Alberola-Ila, J., Forbush, K.A., Seger, R., Krebs, E.G. & Perlmutter, R.G. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373, 620-623 (1995).
28. Sugawara, T., Moriguchi, T., Nishida, E. & Takahama, Y. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes. Immunity 9, 565-574 (1998).
29. + thymocytes by T-cell receptor peptide antagonists. Proc. Natl. Acad. Sci. USA 91, 4057-4061 (1994).
30. Davey, N.J. et al. Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells. J. Exp. Med. 188, 1867-1874 (1998).
31. Lucas, B., Stefanová, I., Yasutomo, K., Dautigny, N. & Germain, R.N. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. Cell 10, 367-376 (1999).
32. Jardetzky, T.S., Lane, W.S., Robinson, R.A. & Wiley, D.C. Identification of self peptides bound to purified HLA-B27. Nature 353, 326-329 (1991).
33. Marrack, P., Ignatowicz, L., Kappler, J.W., Boymel, J. & Freed, J.H. Comparison of peptides bound to spleen and thymus class II. J. Exp. Med. 178, 2173-2183 (1993)
34. Barton, T. & Rudensky, A.Y. Requirement for diverse, low-abundance peptides in positive selection of T cells. Science 283, 67-70 (1999).
35. + T cells. Immunity 7, 209-219 (1997).
36. Nakano, N., Rooke, R., Benoist, C. & Mathis, D. Positive selection of T cells induced by viral delivery of neopeptides to the thymus. Science 275, 678-683 (1997).
37. Sant'Angelo, D.B. et al. The imprint of intrathymic self-peptides on the mature T cell receptor repertoire. Immunity 7, 517-524 (1997).
38. Chimielowski, B., Muranski, P. & Ignatowicz, L. In the normal repertoire of CD4+ T cells, a single class II MHC/peptide complex positively selects TCRs with various antigen specificities. J. Immunol. 162, 95-105 (1999).
39. Grubin, C.E., Kovats, S., deRoos. P. & Rudensky, A.Y. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7, 197-208 (1997).
40. Pawlowski, T.J., Singleton, M.D., Loh, D.Y., Berg, R. & Staerz, U.D. Permissive recognition during positive selection. Eur. J. Immunol. 26, 851-857 (1996).
41. Ignatowicz, L., Kappler, J. & Marrack, P. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84, 521-529 (1996).
42. 0-0 mice. Immunity 7, 187-195 (1997).
43. Liu, C.-P., Crawford, F., Marrack, P. & Kappler, J. T cell positive selection by a high density, low affinity ligand. Proc. Natl. Acad. Sci. USA 95, 4522-4526 (1998).
44. Gapin, L. et al. Quantitative analysis of the T cell repertoire selected by a single peptide-major histocompatibility complex. J. Exp. Med. 187, 1871-1883 (1998).
45. Cavenagh, J.D., Milne, T.M., Macey, M.G. & Newland, A.C. Thymic function in adults: evidence derived from immune recover patterns following myeloablative chemotherapy and stem cell infusion. Br. J. Haematol 97, 673-676 (1997).
46. Weinberg, K. et al. The effect of thymic function on immunocompetence following bone marrow transplantation, Biol. Blood Marrow Transplant. 1, 18-23 (1995).
47. + T-lymphocyte regeneration after intensive chemotherapy. N. Engl. J. Med. 332, 143-149 (1995).
48. Douek, D.C. et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 396, 690-695-(1998).
49. β genes in aging mice. J. Immunol. 149, 230-236 (1992).
50. Mackall, C.L., Punt, J.A., Morgan, P., Farr, A.G. & Gress, R.E. Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution. Eur. J. Immunol. 28, 1886-1893 (1998).
51. Kuhlman, P., Moy, V.T., Lollo, B.A. & Brian, A.A. The accessory function of murine intercellular adhesion molecule-1 in T lymphocyte activation. J. Immunol. 146, 1773-1782 (1991).
52. Rubin, R.L., Uetrecht, J.P. & Jones, J.E. Cytotoxicity of oxidative metabolites of procainamide. J. Phormacol. Exp. Ther. 242, 833-841 (1987).
53. Burlingame, R.W. & Rubin, R.L. Subnucleosome structures as substrates in enzyme-linked immunosorbent assays. J. Immunol. Meth. 134, 187-199 (1990).
54. Lyons, A.B. & Parish, C.R. Determination of lymphocyte division by flow cytometry. J. Immunol. Meth. 171, 131-137 (1994).
55. Jenkinson, E.J., Anderson, G. & Owen, J.J.T. Studies on T cell maturation on defined thymic stromal cell populations in vitro. J. Exp. Med. 845-852 (1992).
56. Kretz-Rommel, A. & Rubin, R.L. A metabolite of the lupus-inducing drug procainamide prevents anergy induction in T cell clones. J. Immunol. 158, 4465-4470 (1997).