Analysis of the α4β1 integrin-osteopontin interaction

Experimental Cell Research

Volumn 258, Issue 2, 2000, Pages 342-351

  Barry, Simon T ^a   Ludbrook, Steven B ^a   Murrison, Elaine ^a   Horgan, Carmel M T ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Adhesion; Extracellular matrix; Inflammation; Osteopontin; 4 1 integrin

Indexed keywords

INTEGRIN; OSTEOPONTIN; HOMING RECEPTOR; HYBRID PROTEIN; SIALOGLYCOPROTEIN; SPP1 PROTEIN, HUMAN; VERY LATE ACTIVATION ANTIGEN 4;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL ADHESION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; AMINO ACID SEQUENCE; CELL LINE; CHROMOSOME MAP; GENE EXPRESSION; GENETICS; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY;

AMINO ACID SEQUENCE; BINDING SITES; CELL ADHESION; CELL LINE; CHROMOSOME MAPPING; GENE EXPRESSION; HUMANS; INTEGRIN ALPHA4BETA1; INTEGRINS; MOLECULAR SEQUENCE DATA; OSTEOPONTIN; RECEPTORS, LYMPHOCYTE HOMING; RECOMBINANT FUSION PROTEINS; SIALOGLYCOPROTEINS;

EID: 0034238108     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.4941     Document Type: Article

References (56)

1. Hynes R. O. Integrins: Versatility, modulation, and signalling in cell adhesion. Cell. 69:1992;11-25.
2. Clark E. A., Brugge J. S. Integrins and signal transduction pathways: The road taken. Science. 268:1995;233-239.
3. Lobb R. R., Hemler M. E. The pathophysiologic role of alpha 4 integrins in vivo. J. Clin. Invest. 94:1994;1722-1728.
4. Springer T. A. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell. 76:1994;301-314.
5. Carlos T. M., Harlan J. M. Leukocyte-endothelial adhesion molecules. Blood. 84:1994;2068-2101.
6. Duplaa C., Couffinhal T., Dufourcq P., Llanas B., Moreau C., Bonnet J. The integrin very late antigen-4 is expressed in human smooth muscle cell. Involvement of alpha 4 and vascular cell adhesion molecule-1 during smooth muscle cell differentiation. Circ. Res. 80:1997;159-169.
7. Taichman D. B., Cybulsky M. I., Djaffar I., Longenecker B. M., Teixido J., Rice G. E., Aruffo A., Bevilacqua M. P. Tumor cell surface alpha 4 beta 1 integrin mediates adhesion to vascular endothelium: Demonstration of an interaction with the N-terminal domains of INCAM-110/VCAM-1. Cell Regul. 2:1991;347-355.
8. Qian F., Vaux D. L., Weissman I. L. Expression of the integrin alpha 4 beta 1 on melanoma cells can inhibit the invasive stage of metastasis formation. Cell. 77:1994;335-347.
9. Alon R., Kassner P. D., Carr M. W., Finger E. B., Hemler M. E., Springer T. A. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J. Cell Biol. 128:1995;1243-1253.
10. Berlin C., Bargatze R. F., Campbell J. J., von Andrian U. H., Szabo M. C., Hasslen S. R., Nelson R. D., Berg E. L., Erlandsen S. L., Butcher E. C. Alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell. 80:1995;413-422.
11. Bochner B. S., Luscinskas F. W., Gimbrone M. A. Jr., Newman W., Sterbinsky S. A., Derse-Anthony C. P., Klunk D., Schleimer R. P. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: Contributions of endothelial cell adhesion molecules. J. Exp. Med. 173:1991;1553-1556.
12. Ferguson T. A., Mizutani H., Kupper T. S. Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo. Proc. Natl. Acad. Sci. USA. 88:1991;8072-8076.
13. Wahl S. M., Allen J. B., Hines K. L., Imamichi T., Wahl A. M., Furcht L. T., McCarthy J. B. Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment. J. Clin. Invest. 94:1994;655-662.
14. Molossi S., Elices M., Arrhenius T., Diaz R., Coulber C., Rabinovitch M. Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts. J. Clin. Invest. 95:1995;2601-2610.
15. Shih P. T., Brennan M. L., Vora D. K., Territo M. C., Strahl D., Elices M. J., Lusis A. J., Berliner J. A. Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet. Circ. Res. 84:1999;345-351.
16. Elices M. J., Osborn L., Takada Y., Crouse C., Luhowskyj S., Hemler M. E., Lobb R. R. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell. 60:1990;577-584.
17. Newham P., Craig S. E., Seddon G. N., Schofield N. R., Rees A., Edwards R. M., Jones E. Y., Humphries M. J. Alpha4 integrin binding interfaces on VCAM-1 and MAdCAM-1. Integrin binding footprints identify accessory binding sites that play a role in integrin specificity. J. Biol. Chem. 272:1997;19429-19440.
18. Guan J. L., Hynes R. O. Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1. Cell. 60:1990;53-61.
19. Mould A. P., Humphries M. J. Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin. EMBO J. 10:1991;4089-4095.
20. Moyano J. V., Carnemolla B., Dominguez-Jimenez C., Garcia-Gila M., Albar J. P., Sanchez-Aparicio P., Leprini A., Querze G., Zardi L., Garcia-Pardo A. Fibronectin type III5 repeat contains a novel cell adhesion sequence, KLDAPT, which binds activated alpha4beta1 and alpha4beta7 integrins J. Biol. Chem. 272:1997;24832-24836.
21. Bayless K. J., Meininger G. A., Scholtz J. M., Davis G. E. Osteopontin is a ligand for the alpha4beta1 integrin. J. Cell Sci. 111:1998;1165-1174.
22. Masumoto A., Hemler M. E. Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1. J. Biol. Chem. 268:1993;228-234.
23. Chen L. L., Whitty A., Lobb R. R., Adams S. P., Pepinsky R. B. Multiple activation states of integrin alpha4beta1 detected through their different affinities for a small molecule ligand. J. Biol. Chem. 274:1999;13167-13175.
24. Chan B. M., Wong J. G., Rao A., Hemler M. E. T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix. J. Immunol. 147:1991;398-404.
25. Shimizu Y., Van Seventer G. A., Horgan K. J., Shaw S. Regulated expression and binding of three VLA (beta 1) integrin receptors on T cells. Nature. 345:1990;250-253.
26. Giachelli C. M., Schwartz S. M., Liaw L. Molecular and cellular biology of osteopontin: Potential role in cardiovascular disease. Trends Card. Med. 5:1995;88-95.
27. Denhardt D. T., Guo X. Osteopontin: A protein with diverse functions. FASEB J. 7:1993;1475-1482.
28. Butler W. T. The nature and significance of osteopontin. Connect. Tissue Res. 23:1989;123-136.
29. Liaw L., Birk D. E., Ballas C. B., Whitsitt J. S., Davidson J. M., Hogan B. L. Altered wound healing in mice lacking a functional osteopontin gene (Supp1). J. Clin. Invest. 101:1998;1468-1478.
30. Panda D., Kundu G. C., Lee B. I., Peri A., Fohl D., Chackalaparampil I., Mukherjee B. B., Li X. D., Mukherjee D. C., Seides S., Rosenberg J., Stark K., Mukherjee A. B. Potential roles of osteopontin and alphaVbeta3 integrin in the development of coronary artery restenosis after angioplasty. Proc. Natl. Acad. Sci. USA. 94:1997;9308-9313.
31. Bennett J. S., Chan C., Vilaire G., Mousa S. A., DeGrado W. F. Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin. J. Biol. Chem. 272:1997;8137-8140.
32. Liaw L., Lindner V., Schwartz S. M., Chambers A. F., Giachelli C. M. Osteopontin and beta 3 integrin are co-ordinately expressed in regenerating endothelium in vivo and stimulate Arg-Gly-Asp-dependent endothelial migration in vitro. Circ. Res. 77:1995;665-672.
33. Giachelli C. M., Bae N., Almeida M., Denhardt D. T., Alpers C. E., Schwartz S. M. Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. J. Clin. Invest. 92:1993;1686-1696.
34. Giachelli C. M., Pichler R., Lombardi D., Denhardt D. T., Alpers C. E., Schwartz S. M., Johnson R. J. Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis. Kidney Int. 45:1994;515-524.
35. Pichler R., Giachelli C. M., Lombardi D., Pippin J., Gordon K., Alpers C. E., Schwartz S. M., Johnson R. J. Tubulointerstitial disease in glomerulonephritis. Potential role of osteopontin (uropontin). Am. J. Pathol. 144:1994;915-926.
36. Lan H.-Y., Yu X. Q., Yang N., Nikolic-Paterson D. J., Mu W., Pichler R., Johnson R. J., Atkins R. C. De novo glomerular osteopontin expression in rat crescentic glomerulonephritis. Kidney Int. 53:1998;136-145.
37. Rittling S. R., Novick K. E. Osteopontin expression in mammary gland development and tumorigenesis. Cell Growth Differ. 8:1997;1061-1069.
38. Craig A. M., Smith J. H., Denhardt D. T. Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis. J. Biol. Chem. 264:1989;9682-9689.
39. Senger D. R., Perruzzi C. A., Papadopoulous A. Elevated expression of secreted phosphoprotein I (osteopontin, 2ar) as a consequence of neoplastic transformation. Anticancer Res. 9:1989;1291-1299.
40. Liaw L., Skinner M. P., Raines E. W., Ross R., Cheresh D. A., Schwartz S. M., Giachelli C. M. The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro. J. Clin. Invest. 95:1995;713-724.
41. O'Regan A. W., Chupp G. L., Lowry J. A., Goetschkes M., Mulligan N., Berman J. S. Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro. J. Immunol. 162:1999;1024-1031.
42. Hu D. D., Lin E. C., Kovach N. L., Hoyer J. R., Smith J. W. A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5. J. Biol. Chem. 270:1995;26232-26238.
43. Miyauchi A., Alvarez J., Greenfield E. M., Teti A., Grano M., Colucci S., Zambonin-Zallone A., Ross F. P., Teitelbaum S. L., Cheresh D. Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts. J. Biol. Chem. 266:1991;20369-20374.
44. Ross F. P., Chappel J., Alvarez J. I., Sander D., Butler W. T., Farach-Carson M. C., Mintz K. A., Robey P. G., Teitelbaum S. L., Cheresh D. A. Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption. J. Biol. Chem. 268:1993;9901-9907.
45. Liaw L., Almeida M., Hart C. E., Schwartz S. M., Giachelli C. M. Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro. Circ. Res. 74:1994;214-224.
46. Hu D. D., Hoyer J. R., Smith J. W. Ca2+ suppresses cell adhesion to osteopontin by attenuating binding affinity for integrin alpha v beta 3. J. Biol. Chem. 270:1995;9917-9925.
47. Denda S., Reichardt L. F., Muller U. Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis. Mol. Biol. Cell. 9:1998;1425-1435.
48. Smith L. L., Cheung H.-K., Ling L. E., Chen J., Sheppard D., Pytela R., Giachelli C. M. Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin. J.Biol. Chem. 271:1996;28485-28491.
49. Smith L. L., Giachelli C. M. Structural requirements for alpha 9 beta 1-mediated adhesion and migration to thrombin-cleaved osteopontin. Exp. Cell Res. 242:1998;351-360.
50. Barry S. T., Ludbrook S. B., Murrison E., Horgan C. M. T. Biochem. Biophys. Res. Commun. 267:2000;764-769.
51. Yokosaki Y., Matsuura N., Sasaki T., Murakami I., Schneider H., Higashiyama S., Saitoh Y., Yamakido M., Taooka Y., Sheppard D. The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. J. Biol. Chem. 274:1999;36328-35334.
52. Senger D. R., Perruzzi C. A., Papadopoulos-Sergiou A., Van Der Water L. Adhesive properties of osteopontin: Regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain. Mol. Biol. Cell. 5:1994;565-574.
53. Lin K.-C., Ateeq H. S., Lee W-C., Zimmerman C. N., Castro A., Hammond C., Halkunte S., Chen L. L., Pepinsky R. B., Leone D. R., Sprague A. G., Abraham W. M., Gill A., Lobb R. R., Adams S. P. Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. J. Med. Chem. 42:1999;920-934.
54. Sanchez-Aparicio P., Domingez-Jimenenz C., Garcia-Pardo A. Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin. J. Cell Biol. 126:1994;271-279.
55. Taooka Y., Chen J., Yednock T., Sheppard D. The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1. J. Cell Biol. 145:1999;413-420.
56. Palmer E. L., Ruegg C., Ferando R., Pytela R., Sheppard D. Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle. J. Cell Biol. 123:1993;1289-1297.