CD4+IL13+ T lymphocytes at birth and the development of wheezing and/or asthma during the 1st year of life

International Archives of Allergy and Immunology

Volumn 124, Issue 4, 2001, Pages 497-501

  Spinozzi, Fabrizio ^a   Agea, Elisabetta ^b   Russano, Anna ^b   Bistoni, Onelia ^b   Minelli, Liliana ^b   Bologni, Donatella ^b   Bertotto, Alberto ^b   De Benedictis, Fernando M ^b  

^a POLICLINICO MONTELUCE   (Italy)

^b NONE

Author keywords

Asthma; Cord blood; Cytokines; Newborns; T lymphocytes; Th2 cells

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5;

ARTICLE; ASTHMA; BIRTH; CHILDHOOD DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; T LYMPHOCYTE; TH2 CELL; UMBILICAL CORD BLOOD; WHEEZING;

ASTHMA; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COHORT STUDIES; CYTOKINES; FETAL BLOOD; HUMANS; INFANT; INFANT, NEWBORN; INTERLEUKIN-13; PROSPECTIVE STUDIES; RESPIRATORY SOUNDS; TH2 CELLS;

EID: 0035014542     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053785     Document Type: Article

References (32)

1. Bochner BS, Undem BJ, Lichtenstein LM: Immunological aspects of allergic asthma. Annu Rev Immunol 1994;12:295-335.
2. Barnes KC, Marsh DG: The genetics and complexity of allergy and asthma. Immunol Today 1998;19:325-332.
3. Moffat MF, Cookson WO: The genetics of asthma. Maternal effects in atopic disease. Clin Exp Allergy 1998;28(suppl 1):56-61.
4. Yang LP, Byun DG, Demeure CE, Vezzio N, Delespesse G: Default development of cloned naive CD4 T cells into interleukin-4 and interleukin-5-producing effector cells. Eur J Immunol 1995;25:3517-3520.
5. Piccinni MP, Beloni L, Giannarini L et al: Abnormal production of T helper type-2 cyto kines interleukin-4 and interleukin-5 by T cells from newborns from atopic parents. Em J Immunol 1996;26:2293-2298.
6. Gern JE, Lemanske RF, Busse WW: Early life origins of asthma. J Clin Invest 1999;104:837-843.
7. Marshall-Clarke S, Reen D, Tasker L, Hassan J: Neonatal immunity: How well has it grown up? Immunol Today 2000;21:35-41.
8. Holt PG, Macaubas C, Stumbles PA, Sly PD: The role of allergy in the development of asthma. Nature 1999;402(suppl):B12-B17.
9. McKenzie GJ, Emson CL, Bell SE, et al: Impaired development of TH2 cells in IL-13-deficient mice. Immunity 1999;9:423-432.
10. Gauchat JF, Schlagenhauf E, Feng NP, et al: A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor. Eur J Immunol 1997;27:971-978.
11. Corry DB: IL-13 in allergy: Home at last. Curr Opin Immunol 1999;11:610-614.
12. Vogel G: Interleukin-13's key role in asthma shown. Science 1998;282:2168.
13. European Community Respiratory Health Survey: Prevalence of asthma and asthma symptoms in a general population sample from northern Italy. Allergy 1995;50:755-759.
14. Asher MI, Keil U, Anderson HR, et al: International Study of Asthma and Allergies in Childhood (ISAAC): Rationale and methods. Eur Respir J 1995;8:483-491.
15. Jung T, Schauer U, Heusser C, Neumann C, Rieger C: Detection of intracellular cytokines by flow cytometry. J Immunol Methods 1993; 159:197-207.
16. Seder RA, Paul WE: Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 1994;12:635-673.
17. Yashimoto T, Paul WE: CD4+NK1.1+ T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med 1994;179:1285-1295.
18. Swain SL, Weinberg AD, English M, Huston G: 1L-4 directs the development of Th2-like helper effectors. J Immunol 1990;145:3796-3806.
19. Romagnani S: Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994;12:227-258.
20. Prescott SL, Holt PG: Abnormalities in cord blood mononuclear cytokine production as a predictor of later atopic disease in childhood. Clin Exp Allergy 1998;28:1313-1316.
21. Björkstén B: Allergy priming early in life. Lancet 1999;353:167-168.
22. Wills-Karp M: Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 1999;17:255-281.
23. Melhop PD, Van de Rijn M, Goldberg AB, Brewer JP, Kurup VP, Martin TR, Oettgen HC: Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in mouse model of asthma. Proc Natl Acad Sci USA 1997;94:1344-1349.
24. Krampera M, Tavecchia L, Benedetti F, Nadali G, Pizzolo G: Intracellular cytokine profile of cord blood T-, and NK-cells and monocytes. Haematologica 2000;85:675-679.
25. von Freeden U, Zessack N, van Valen F, Burdach S: Defective Interferon gamma production in neonatal T cells is independent of interleukin-2 receptor binding. Pediatr Res 1991; 30:270-278.
26. Warner JA, Miles EA, Jones AC, Quint DJ, Colwell BM, Warner JO: Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema? Clin Exp Allergy 1994;24:423-430.
27. Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Holt PG: Development of allergen-specific T-cell memory in atopic and normal children. Lancet 1999;353:196-200.
28. Grunig G, Warnock M, Wakil AE, et al: Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998;282:2261-2263.
29. Kaplan MH, Schindler U, Smiley ST, Grusby MJ: Stat6 is required tor mediating responses to IL-4 and for development of Th2 cells. Immunity 1996;4:311-319.
30. Zhu Z, Homer RJ, Wang Z, et al: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities and eotaxin production. J Clin Invest 1999;103:779-788.
31. Izuhara K, Shirakawa T: Signal transduction via the interleukin-4 receptor and its correlation with atopy. Int J Mol Med 1999;3:3-10.
32. Heinzmann A, Mao X, Akaiwa M, et al: Genetic variants of IL-13 signaling and human asthma and atopy. Hum Mol Genet 2000;9:549-559.