Human peripheral blood T cells, monocytes, and macrophages secrete macrophage inflammatory proteins 1α and 1β following stimulation with heat-inactivated Brucella abortus

Infection and Immunity

Volumn 69, Issue 6, 2001, Pages 3817-3826

  Zaitseva, M ^a   King, L R ^a   Manischewitz, J ^a   Dougan, M ^a   Stevan, L ^a   Golding, H ^a   Golding, B ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BETA CHEMOKINE; CHEMOKINE RECEPTOR CCR5; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NEUTRALIZING ANTIBODY;

ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ANTIVIRAL ACTIVITY; ARTICLE; BRUCELLA ABORTUS; CELL FUSION; CELLULAR IMMUNITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMORAL IMMUNITY; IMMUNE DEFICIENCY; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VACCINATION; VIRUS ENVELOPE;

AIDS VACCINES; BRUCELLA ABORTUS; CD8-POSITIVE T-LYMPHOCYTES; HEAT; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MACROPHAGE INFLAMMATORY PROTEIN-1; MACROPHAGES; MEMBRANE FUSION; MONOCYTES; T-LYMPHOCYTES;

EID: 0035010113     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.6.3817-3826.2001     Document Type: Article

References (38)

1. Limited expression of R5-tropic HIV-1 in CCR5-positive type I polarized T cells explained by their ability to produce RANTES, MIP-1α, and MIP-1β
2. Lipopolysaccharide from Brucella abortus behaves as a T-cell-independent type 1 carrier in murine antigen-specific antibody responses
3. Brucella abortus stimulates human T cells from uninfected and infected individuals to secrete IFNγ
4. + T cells
5. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion of the CKR5 structural allele
6. Identification of a major co-receptor for primary isolates of HIV-1
7. + cells is mediated by the CC-CKR-5
8. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane G protein coupled receptor
9. Spontaneous and antigen-induced production of HIV-inhibitory β-chemokines are associated with AIDS-free status
10. Production of a novel antigen by conjugation of HIV-1 to Brucella abortus: Studies of immunogenicity, isotype analysis, T-cell dependency, and syncytia inhibition
11. + T-cell depletion
12. Design of vaccines for the induction of antibody responses in Th-cell deficient individuals
13. Immunity and protection against Brucella abortus
14. Strategies for the stimulation of CD4/CD8 T subsets
15. Lipopolysaccharide from Brucella abortus is less toxic than lipopolysaccharide from Escherichia coli, suggesting the possible use of B. abortus as a carrier in vaccines
16. Beta chemokines and neutralization antibody titers correlate with sterilizing immunity generated in HIV-1 vaccinated macaques
17. Lipopolysaccharide from an Escherichia coli htrB msbB mutant induces high levels of MIP-1α and MIP-1β secretion without inducing TNF-α and IL-1β
18. Induction and regulation of Th1-inducing cytokines by bacterial DNA, lipopolysaccharide, and heat-inactivated bacteria
19. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression
20. OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway
21. Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines
22. + cell-depleted BALB/c mice
23. Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques
24. A rational basis for mucosal vaccination against HIV infection
25. Up-regulation of beta chemokines and down-modulation of CCR5 co-receptors inhibit simian immunodeficiency virus transmission in non-human primates
26. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
27. Bone marrow CD34(+) cells and megakaryoblasts secrete β-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV
28. Preformed membrane-associated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite
29. +, T-cell clones correlates with the clinical state of human immunodeficiency virus type 1 (HIV-1)-infected individuals and may be responsible for blocking infection with non-syncytium-inducing HIV-1 in vitro
30. Resistance to HIV-1 infection of Caucasian individuals bearing mutant alleles of the CKR5 chemokine receptor gene
31. Synthesis of β-chemokines MIP-1α, MIP-1β, and RANTES is associated with a type 1 immune response
32. HIV peptide conjugated to heat-killed bacteria promotes antiviral responses in immunodeficient mice
33. T cell stimulation in vivo by lipopolysaccharide (LPS)
34. C-C chemokines released by lipopolysaccharide (LPS)-stimulated human macrophages suppress HIV-1 infection in both macrophages and T cells
35. Interferon gamma and interleukin 6 modulate the susceptibility of macrophages to human immunodeficiency virus type 1 infection
36. + T cells express Th1-like cytokine mRNA and proteins following in vitro stimulation with heat-inactivated Brucella abortus
37. Brucella abortus as a potential vaccine candidate. Induction of interleukin-12 secretion and enhanced B7.1, B7.2, and intercellular adhesion molecule 1 surface expression in elutriated monocytes stimulated by heat-inactivated B. abortus
38. Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry?