Characterization of the CDKN2A and ARF genes in UV-induced melanocytic hyperplasias and melanomas of an opossum (Monodelphis domestica)

Molecular Carcinogenesis

Volumn 31, Issue 1, 2001, Pages 16-26

  Chan, Jeannie ^a   Robinson, Edward S ^a   Atencio, Julia ^b   Wang, Zhiqiang ^b   Kazianis, Steven ^b   Coletta, Luis Della ^a   Nairn, Rodney S ^a   McCarrey, John R ^b  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Cancer; Gene expression; Melanoma; Monodelphis; Mutation

Indexed keywords

ARF PROTEIN; COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GENE PRODUCT; UNCLASSIFIED DRUG;

ADOLESCENT; ALLELE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL HYPERPLASIA; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE MUTATION; MALE; MELANOCYTE; MELANOMA CELL; MOLECULAR CLONING; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; OPOSSUM; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRAVIOLET B RADIATION;

ANIMALS; DNA PRIMERS; GENES, P16; HYPERPLASIA; MALE; MELANOCYTES; MELANOMA; MUTATION; NEOPLASMS, RADIATION-INDUCED; OPOSSUMS; PHYLOGENY; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; READING FRAMES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN NEOPLASMS; TESTIS; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

DIDELPHIDAE; MONODELPHIS; MONODELPHIS DOMESTICA;

EID: 0035004825     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.1033     Document Type: Article

References (46)

1. Ultraviolet radiation induced signature mutations in photocarcinogenesis
2. Monodelphis domestica: A new animal model for studies in photodermatology
3. Malignant melanoma in ultraviolet irradiated laboratory opossums: Initiation in suckling young, metastasis in adults, and xenograft behavior in nude mice
4. Low-dose ultraviolet exposure early in development can lead to widespread melanoma in the opossum model
5. INK4a/CDKN2A tumor suppressor and its relatives
6. Malignant melanoma: Modern black plague and genetic black box
7. The INK4A/ARF locus and its two gene products
8. The INK4a/ARF locus in murine tumorigenesis
9. Separation of mouse spermatogenic cells by sedimentation velocity
10. Differential transcription of Pgk genes during spermatogenesis in the mouse
11. Genetic analysis of ultraviolet radiation-induced skin hyperplasia and neoplasia in a laboratory marsupial model (Monodelphis domestica)
12. UV-induced melanoma. A karyotype with a single translocation is stable after allografting and metastasis
13. Cell lines derived from ultraviolet radiation-induced benign melanocytic nevi in Monodelphis domestica exhibit cytogenetic aneuploidy
14. 'Touchdown' PCR to circumvent spurious priming during gene amplification
15. Comparative structure and characterization of a CDKN2 gene in a Xiphophorus fish melanoma model
16. Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer
17. Calibrated user-friendly reverse transcriptase-PCR assay: Quantitation of epidermal growth factor receptor mRNA
18. 'Cold SSCP': A simple, rapid and non-radioactive method for optimized single-strand conformation polymorphism analyses
19. Cloning and characterization of the CDKN2A and p19ARF genes from Monodelphis domestica
20. INK4b genes
21. INK4a tumor suppressor versus other INK4 family members during mouse development and aging
22. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma
23. Skin melanoma induced by 7,12-dimethylbenzanthracene in albino guinea pigs and its similarities to skin melanoma of humans
24. Role of ultraviolet radiation in the induction of melanocytic tumors in hairless mice following 7,12-dimethylbenz(a)anthracene application and ultraviolet irradiation
25. The role of ultraviolet radiation in the induction of melanocytic skin tumors in inbred mice
26. Ultraviolet radiation-induced malignant skin melanoma in melanoma-susceptible transgenic mice
27. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor
28. Development of heritable melanoma in transgenic mice
29. Induction of melanoma in TPras transgenic mice
30. Essential role for oncogenic Ras in tumour maintenance
31. Low frequency of p16/CDKN2A methylation in sporadic melanoma: Comparative approaches for methylation analysis of primary tumors
32. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
33. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
34. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
35. ARF genes in sporadic primary melanomas
36. Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets
37. INK4d
38. Evidence for u.v. induction of CDKN2 mutations in melanoma cell lines
39. INK4/MTS-1) gene in human melanoma cells: Relevance to tumor growth and metastasis
40. ARF
41. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
42. INK4b tumor suppressor genes in a subset of human sporadic cutaneous malignant melanoma
43. INK4a inactivation is not frequent in uncultured sporadic primary cutaneous melanoma
44. Overexpression of a fish CDKN2 gene in a hereditary melanoma model
45. The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis
46. INK4a-pRb regulatory pathway in cultured melanoma cells