Overexpression of a fish CDKN2 gene in a hereditary melanoma model

Carcinogenesis

Volumn 21, Issue 4, 2000, Pages 599-605

  Kazianis, Steven ^a   Della Coletta, Luis ^a   Morizot, Donald C ^a   Johnston, Dennis A ^a   Osterndorff, Elizabeth A ^a   Nairn, Rodney S ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYTOSINE; PIGMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EXON; FISH; GENE DELETION; GENE MAPPING; GENE MUTATION; MELANOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

EID: 0034091823     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.4.599     Document Type: Article

References (65)

1. Gordon, M. (1927) The genetics of a viviparous top-minnow Platypoecilus; the inheritance of two kinds of melanophores. Genetics, 12, 253-283.
2. Kallman, K.D. (1975) The platyfish, Xiphophorus maculatus. In King, R.C. (ed.) Handbook of Genetics. Plenum Publishing Corporation, New York, Vol. 4, pp. 81-132.
3. Wittbrodt, J., Adam, D., Malitschek, B., Maueler, W., Raulf, F., Telling, A., Robertson, S. and Schartl, M. (1989) Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus. Nature, 341, 415-421.
4. Woolcock, B.W., Schmidt, B.M., Kallman, K.D. and Vielkind, J.R. (1994) Differences in transcription and promoters of Xmrk-1 and Xmrk-2 genes suggest a role for Xmrk-2 in pigment pattern development in the platyfish Xiphophorus maculatus. Cell Growth Differ., 5, 575-583.
5. Zechel, C., Schleenbecker, U., Anders, A., Pfutz, M. and Anders, F. (1989) Search for genes critical for the early and/or late events in carcinogenesis: studies in Xiphophorus (Pisces, Teleostei). Haematol. Blood Transfus., 32, 366-385.
6. Wellbrock, C., Fischer, P. and Schartl, M. (1998) Receptor tyrosine kinase Xmrk mediates proliferation in Xiphophorus melanoma cells. Int. J. Cancer, 76, 437-442.
7. Wellbrock, C. Gomez, A. and Schartl, M. (1997) Signal transduction by the oncogenic receptor tyrosine kinase Xmrk in melanoma formation of Xiphophorus. Pigment Cell Res., 10, 34-40.
8. Schartl, M. (1990) Homology of melanoma-inducing loci in the genus Xiphophorus. Genetics, 126, 1083-1091.
9. Kazianis, S. and Borowsky, R. (1995) Stable association of a pigmentation allele with an oncogene: non-hybrid melanomas in Xiphophorus variatus. J. Hered., 86, 199-203.
10. Anders, A., Anders, F. and Klinke, K. (1973) Regulation of gene expression in the Gordon-Kosswig melanoma system I. The distribution of the controlling genes in the genome of the xiphophorin fish, Platypoecilus maculatus and Platypoecilus variatus. In Schroder, J.H. (ed.) Genetics and Mutagenesis of Fish. Springer-Verlag, Berlin, Heidelberg, New York, pp. 33-52.
11. Zander, C.D. (1969) Uber die enstehung und veranderung von farbmustern in der gattung Xiphophorus (Pisces). Mitt. Hamburg. Zool. Mus. Inst., 66, 241-271.
12. Gordon, M. (1958) A genetic concept for the origin of melanomas. Ann. NY Acad. Sci., 71, 1213-1222.
13. Nairn, R., Morizot, D., Kazianis, S., Woodhead, A. and Setlow, R. (1996) Nonmammalian models for sunlight carcinogenesis: genetic analysis of melanoma formation in Xiphophorus hybrid fish. Photochem. Photobiol., 64, 440-448.
14. Ahuja, M.R., Schwab, M. and Anders, F. (1980) Linkage between a regulatory locus for melanoma cell differentiation and an esterase locus in Xiphophorus. J. Hered., 71, 403-407.
15. Setlow, R.B., Woodhead, A.D. and Grist, E. (1989) Animal model for ultraviolet radiation-induced melanoma: platyfish-swordtails hybrid. Proc. Natl Acad. Sci. USA, 86, 8922-8926.
16. Setlow, R.B., Grist, E., Thompson, K. and Woodhead, A.D. (1993) Wavelengths effective in induction of malignant melanoma. Proc. Natl Acad Sci. USA, 90, 6666-6670.
17. Kazianis, S., Morizot, D.C., Della Coletta, L., Johnston, D.A., Woolcock, B., Vielkind, J.R. and Nairn, R.S. (1999) Comparative structure and characterization of a CDKN2 gene in a Xiphophorus fish melanoma model. Oncogene, 18, 5088-5099.
18. Vielkind, U. (1976) Genetic control of cell differentiation in platyfish-swordtail melanomas. J. Exp. Zool., 196, 197-204.
19. Siciliano, M.J., Morizot, D.C. and Wright, D.A. (1976) Factors responsible for platyfish-swordtail hybrid melanomas - many or few? In Riley, V. (ed.) Pigment Cell. Karger, Basel, Vol. 2, pp. 47-58.
20. Kazianis, S., Gutbrod, H., Nairn, R., McEntire, B., Della Coletta, L., Walter, R., Borowsky, R., Woodhead, A., Setlow, R., Schartl, M. and Morizot, D. (1998) Localization of a CDKN2 gene in linkage group V of Xiphophorus fishes defines it as a candidate for the DIFF tumor supressor. Genes Chromosomes Cancer, 22, 210-220.
21. Nairn, R.S., Kazianis, S., McEntire, B.B., Della Coletta, L., Walter, R.B. and Morizot, D.C. (1996) A CDKN2-like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish-swordtail hybrids. Proc. Natl Acad. Sci. USA, 93, 13042-13047.
22. Morizot, D.C. and Siciliano, M.J. (1983) Linkage group V of platyfishes and swordtails of the genus Xiphophorus (Poeciliidae): linkage of loci for malate dehydrogenase-2 and esterase-1 and esterase-4 with a gene controlling the severity of hybrid melanomas. J. Natl Cancer Inst., 71, 809-813.
23. Förnzler, D., Wittbrodt, J. and Schartl, M. (1991) Analysis of an esterase linked to a locus involved in the regulation of the melanoma oncogene and isolation of polymorphic marker sequences in Xiphophorus. Biochem. Genet., 29, 509-524.
24. Ruas, M. and Peters, G. (1998) The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim. Biophys. Acta, 1378, F115-F177.
25. Chin, L., Merlino, G. and DePinho, R.A. (1998) Malignant melanoma: modern black plague and genetic black box. Genes Dev., 12, 3467-3481.
26. Herman, J.G., Jen, J., Merlo, A. and Baylin, S.B. (1996) Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B1. Cancer Res., 56, 722-727.
27. Drexler, H.G. (1998) Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia, 12, 845-859.
28. Hussussian, C.J., Struewing, J.P., Goldstein, A.M., Higgins, P.A.T., Ally, D.S., Sheahan, M.D., Clark, W.H.Jr, Tucker, M.A. and Dracopoli, N.C. (1994) Germline p16 mutations in familial melanoma. Nature Genet., 8, 15-21.
29. Ranade, K., Hussussian, C.J., Sikorski, R.S., Varmus, H.E., Goldstein, A.M., Tucker, M.A., Serrano, M., Hannon, G.J., Beach, D. and Dracopoli, N. (1995) Mutations associated with familial melanoma impair p16INK4 function. Nature Genet., 10, 114-116.
30. Parry, D. and Peters, G. (1996) Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma. Mol. Cell. Biol., 16, 3844-3852.
31. Fargnoli, M.C., Chimenti, S., Keller, G., Soyer, H.P., Dal Pozzo, V., Hofler, H. and Peris, K. (1998) CDKN2a/p16INK4a mutations and lack of p19ARF involvement in familial melanoma kindreds. J. Invest. Dermatol., 111, 1202-1206.
32. Fitzgerald, M.G., Harkin, D.P., Silva-Arrieta, S., MacDonald, D.J., Lucchina, L.C., Unsal, H., O'Neill, E., Koh, J., Finkelstein, D.M., Isselbacher, K.J., Sober, A.J. and Haber, D.A. (1996) Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population. Proc. Natl Acad. Sci. USA, 93, 8541-8545.
33. Kamb, A., Shattuck-Eidens, D., Eeles, R., Liu, Q., Gruis, N.A., Ding, W., Hussey, C., Tran, T., Miki, Y., Weaver-Feldhaus, J., McClure, M., Aitken, J.F., Anderson, D.E., Bergman, W., Frants, R., Goldgar, D.E., Green, A., MacLennan, R., Martin, N.G., Meyer, L.J., Youl, P., Zone, J.J., Skolnick, M.H. and Cannon-Albright, L.A. (1994) Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus. Nature Genet., 8, 22-26.
34. Gruis, N.A., Sandkujl, L.A., van der Velden, P.A., Bergman, W. and Frants, R.R. (1995) CDKN2 explains part of the clinical phenotype in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families. Melanoma Res., 5, 169-177.
35. Wagner, S.N., Wagner, C., Briedigkeit, L. and Goos, M. (1998) Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma. Br. J. Dermatol., 138, 13-21.
36. Maelandsmo, G.M., Florenes, V.A., Hovig, E., Oyjord, T., Engebraaten, O., Holm, R., Borresen, A.L. and Fodstad, O. (1996) Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas. Br. J. Cancer, 73, 909-916.
37. Bartkova, J., Lukas, J., Guldberg, P., Alsner, J., Kirkin, A.F., Zeuthen, J. and Bartek, J. (1996) The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res., 56, 5475-5483.
38. Pollock, P.M., Pearson, J.V. and Hayward, N.K. (1996) Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions. Genes Chromosomes Cancer, 15, 77-88.
39. Herbst, R.A., Gutzmer, R., Matiaske, F., Mommert, S., Kapp, A., Weiss, J., Arden, K.C. and Cavenee, W.K. (1997) Further evidence for ultraviolet light induction of CDKN2 (p16INK4) mutations in sporadic melanoma in vivo. J. Invest. Dermatol., 108, 950.
40. ARF mutations in sporadic melanomas. J. Invest. Dermatol., 112, 825-826.
41. Gonzalgo, M.L., Bender, C.M., You, E.H., Glendening, J.M., Flores, J.F., Walker, G.J., Hayward, N.K., Jones, P.A. and Fountain, J.W. (1997) Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors. Cancer Res., 57, 5336-5347.
42. Funk, J.O., Schiller, P.I., Barrett, M.T., Wong, D.J., Kind, P. and Sander, C.A. (1998) p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanoma. J. Cutan. Pathol., 25, 291-296.
43. Herman, J.G., Merlo, A., Mao, L., Lapidus, R.G., Issa, J.-P.J. and Davidson, N.E. (1995) Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res., 55, 4525-4530.
44. Gonzalez-Zulueta, M., Bender, C.M., Yang, A.S., Nguyen, T., Beart, R.W., Tornout, J.M.V. and Jones, P.A. (1995) Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res., 55, 4531-4535.
45. Aggerholm, A., Guldberg, P., Hokland, M. and Hokland, P. (1999) Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia. Cancer Res., 59, 436-441.
46. Iravani, M., Dhat, R. and Price, C.M. (1997) Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia. Oncagene, 15, 2609-2614.
47. Clark, E. (1950) A method for artificial insemination in viviparous fishes, Science, 112, 722-723.
48. Clark, S.J., Harrison, J., Paul, C.L. and Frommer, M. (1994) High sensitivity mapping of methylated cytosines. Nucleic Acids Res., 22, 2990-2997.
49. Zhang, L.P., Stroud, J.C., Walter, C.A., Adrian, G.S. and McCarrey, J.R. (1998) A gene-specific promoter in transgenic mice directs testis-specific demethylation prior to transcriptional activation in vivo. Biol. Reprod., 59, 284-292.
50. Bird, A.P. (1986) CpG-Rich islands und the function of DNA methylation. Nature, 321, 209-213.
51. Gardiner-Garden, M. and Frommer, M. (1987) CpG islands in vertebrate genomes. J. Mol. Biol., 196, 261-282.
52. Stone, S., Dayananth, P., Jiang, P., Weaver-Feldhaus, J.M., Tavtigian, S.V., Cannon-Albright, L. and Kamb, A. (1995) Genomic structure, expression and mutational analysis of the p15 (MTS2) gene. Oncogene, 11, 987-991.
53. Altschmied, J., Ditzel, L. and Schartl, M. (1997) Hypomethylation of the Xmrk oncogene promoter in melanoma cells of Xiphophorus. Biol. Chem., 378, 1457-1466.
54. Cline, J., Braman, J.C. and Hogrefe, H.H. (1996) PCR fidelity of pfu DNA polymerase and other thermostable DNA polymerases. Nucleic Acids Res., 24, 3546-3551.
55. Baylin, S.B., Herman, J.G., Graff, J.R., Vertino, P.M. and Issa, J.P. (1998) Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv. Cancer Res., 72, 141-196.
56. Cross, S., Kovarik, P. Schmidtke, J. and Bird, A. (1991) Non-methylated islands in fish genomes are GC-poor. Nucleic Acids Res., 19, 1469-1474.
57. Armes, N., Gilley, J. and Fried, M. (1997) The comparative genomic structure and sequence of the surfeit gene homologs in the puffer fish Fugu rubripes and their association with CpG-rich islands. Genome Res., 7, 1138-1152.
58. Bird, A., Tate, P., Nan, X., Campoy, J., Meehan, R., Cross, S., Tweedie, S., Charlton, J. and Macleod, D. (1995) Studies of DNA methylation in animals. J. Cell Sci. Suppl., 19, 37-39.
59. Baudler, M., Duschl, J., Winkler, C., Schartl, M. and Altschmied, J. (1997) Activation of transcription of the melanoma inducing Xmrk oncogene by a GC box element. J. Biol. Chem., 272, 131-137.
60. Emig, R., Magener, A., Ehemann, V., Meyer, A., Stilgenbauer, F., Volkmann, M., Wallwiener, D. and Sinn, H.P. (1998) Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumour proliferation. Br. J Cancer, 78, 1661-1668.
61. Sano, T., Oyama, T., Kashiwabara, K., Fukuda, T. and Nakajima, T. (1998) Immunohistochemical overexpression of p16 protein associated with intact retinoblastoma protein expression in cervical cancer and cervical intraepithelial neoplasia. Pathol. Int., 48, 580-585.
62. Sano, T., Oyama, T., Kashiwabara, K., Fukuda, T. and Nakajima, T. (1998) Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am. J. Pathol., 153, 1741-1748.
63. Shigemasa, K., Hu, C., West, C.M., Clarke, J., Parham, G.P., Parmley, T.H., Korourian, S., Baker, V.V. and O'Brien, T.J. (1997) p16 overexpression: a potential early indicator of transformation in ovarian carcinoma. J. Soc. Gynecol. Invest., 4, 95-102.
64. Asamoto, M., Hori, T., Baba-Toriyama, H., Sano, M., Takahashi, S., Tsuda, H. and Shirai, T. (1998) p16 gene overexpression in mouse bladder carcinomas. Cancer Lett., 127, 9-13.
65. Dracopoli, N.C. and Fountain, J.W. (1996) CDKN2 mutations in melanoma. Cancer Surv., 26, 115-132.