Induction of human β-defensin-2 expression in human astrocytes by lipopolysaccharide and cytokines

Journal of Neurochemistry

Volumn 77, Issue 4, 2001, Pages 1027-1035

  Hao, Hsiao Nan ^a,b   Zhao, Jiun ^b   Lotoczky, Gregory ^b   Grever, William E ^b   Lyman, William D ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Children's Research Center of Michigan   (United States)

Author keywords

Astrocytes; Central nervous system; Cytokines; Human defensin

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; DEFENSIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANTIMICROBIAL ACTIVITY; ARTICLE; ASTROCYTE; CONTROLLED STUDY; EPITHELIUM CELL; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; MICROGLIA; NERVE CELL CULTURE; NEUTROPHIL; PANETH CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTI-INFECTIVE AGENTS; ASTROCYTES; BETA-DEFENSINS; CYTOKINES; FEMALE; FETUS; FIBROBLASTS; HUMANS; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MENINGES; MICROGLIA; PROTEIN ISOFORMS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

BACTERIA (MICROORGANISMS);

EID: 0034998495     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00305.x     Document Type: Article

References (57)

1. Abbott N. J. (2000) Inflammatory mediators and modulation of blood-brain barrier permeability. Cell. Mol. Neurobiol. 20, 131-147.
2. Becker M. N., Diamond G., Verghese M. W. and Randell S. H. (2000) CD14-dependent LPS-induced β-defensin-2 expression in human tracheobronchial epithelium. J. Biol. Chem. 275, 29731-29736.
3. Bevins C. L., Martin-Porter E. and Ganz T. (1999) Defensins and innate host defense of the gastrointestinal tract. Gut 45, 911-915.
4. Bonass W. A., High A. S., Owen P. J. and Devine D. A. (1999) Expression of beta-defensin genes by human salivary glands. Oral Microbiol. Immunol. 14, 371-374.
5. Cai Z., Pan Z. L., Pang Y., Evans O. B. and Rhodes P. G. (2000) Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration. Pediatr Res. 47, 64-72.
6. Daher K. A., Selsted M. E. and Lehrer R. I. (1986) Direct inactivation of viruses by human granulocyte defensins. J. Virol. 60, 1068-1074.
7. Diamond G., Kaiser V., Rhodes J., Russell J. P. and Bevins C. L. (2000) Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells. Infect. Immun. 68, 113-119.
8. Falk W., Goodwin R. H. Jr and Leonard E. J. A. (1980) 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration. J. Immunol. Methods 33, 239-247.
9. Fillebeen C., Dehouck B., Benaissa M., Dhennin-Duthille I., Cecchelli R. and Pierce A. (1999) Tumor necrosis factor-alpha increases lactoferrin transcytosis through the blood-brain barrier. J. Neurochem. 73, 2491-2500.
10. Fulton C., Anderson G. M., Zasloff M., Bull. R. and Quinn A. G. (1997) Expression of natural peptide antibiotics in human skin. Lancet 13, 1750-1751.
11. Ganz T. and Lehrer R. I. (1997) Antimicrobial peptides of leukocytes. Curr. Opin. Hematol. 4, 53-58.
12. Gladstone I. M., Ehrenkranz R. A. and Edergt S. C. (1990) A ten-year review of neonatal sepsis and comparison with the previous five-year experience. Pediatr. Infect. Dis. J. 9, 819-825.
13. Gorter A. D., Eijk P. P., van Wetering S., Hiemstra P. S., Dankert J. and van Alphen L. (1998) Stimulation of the adherence of Haemophilus influenzae to human lung epithelial cells by antimicrobial neutrophil defensins. J. Infect Dis. 178, 1067-1074.
14. Grever W. E., Zhang S., Ge B. and Duncan I. D. (1999) Fractionation and enrichment of oligodendrocytes from developing human brain. J. Neurosci Res. 1, 304-314.
15. Hao H.-N. and Lyman W. D. (1999) HIV infection of fetal human astrocytes: the potential role of a receptor-mediated endocytic pathway. Brain Res. 27, 24-32.
16. Hao H.-N., Chiu F. C., Losev L., Weidenheim K. M., Rashbaum W. K. and Lyman W. D. (1997) HIV infection of human fetal neural cells is mediated by gp120 binding to a cell membrane-associated molecule that is not CD4 nor galactocerebroside. Brain Res. 764, 149-157.
17. Hao H.-N., Zhao J., Lotoczky G., Grever W. E. and Lyman W. D. (2000) Induction of human beta-defensin-2 expression in neural cells: The potential role of blood brain barrier against bacterial infection. Pediatr. Res. 47, 1555.
18. Harder J., Bartels J., Christophers E. and Schroder J. M. (1997) A peptide antibiotic from human skin. Nature 26, 861.
19. Harder J., Meyer-Hoffert U., Teran L. M., Schwichtenberg L., Bartels J., Maune S. and Schroder J. M. (2000) Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. Am. J. Respir. Cell. Mol. Biol. 22, 714-721.
20. Hiratsuka T., Nakazato M., Date Y., Ashitani J., Minematsu T., Chino N. and Matsukura S. (1998) Identification of human beta-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia. Biochem. Biophys. Res. Commun. 28, 943-947.
21. Hoffmann J. A., Kafatos F. C., Janeway C. A. and Ezekowitz R. A. (1999) Phylogenetic perspectives in innate immunity. Science 21, 1313-1318.
22. Kanangat S., Meduri G. U., Tolley E. A., Patterson D. R., Meduri C. U., Pak C., Griffin J. P., Bronze M. S. and Schaberg D. R. (1999) Effects of cytokines and endotoxin on the intracellular growth of bacteria. Infect. Immun. 67, 2834-2840.
23. Kolesnikova T. S., Tikhonov I. I., Petratchenko E. V. and Voitenok N. N. (2000) Neutrophil β-defensin human neutrophil peptide modulates cytoline production in human monocytes and adhesion molecule expression in endothelial cells. Eur. Cytokine Netw. 11, 257-266.
24. Krisanaprakornkit S., Kimball J. R., Weinberg A., Darveau R. P., Bainbridge B. W. and Dale B. A. (2000) Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect. Immun. 68, 2907-2915.
25. Lee S. C., Hatch W. C., Liu W., Kress Y., Lyman W. D. and Dickson D. W. (1993) Productive infection of human fetal microglia by HIV-1. Am. J. Pathol. 143, 1032-1039.
26. Lehrer R. I. and Ganz T. (1992) Defensins: endogenous antibiotic peptides from human leukocytes. Ciba Found. Symp. 171, 276-290.
27. Lehrer R. I. and Ganz T. (1996) Endogenous vertebrate antibiotics. Defensins, protegrins, and ther cysteine-rich antimicrobial peptides. Ann. NY Acad. Sci. 25, 228-239.
28. Lehrer R. I., Lichtenstein A. K. and Ganz T. (1993) Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu. Rev. Immunol. 11, 105-128.
29. Lillard J. W. Jr, Boyaka P. N., Chertov O., Oppenheim J. J. and McGhee J. R. (1999) Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. Proc. Natl. Acad. Sci. USA 19, 651-656.
30. Liu L., Wang L., Jia H. P., Zhao C., Heng H. H. Q., Schutte B. C., McCray P. B. Jr and Ganz T. (1998) Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. Gene 19, 237-244.
31. Maffei F. A., Heine R. P., Whalen M. J., Mortimer L. F. and Carcillo J. A. (1999) Levels of antimicrobial molecules defensin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis. Pediatrics 103, 987-992.
32. Meduri G. U., Kanangat S., Stefan J., Tolley E. and Schaberg D. (1999) Cytokines IL-1beta, IL-6, and TNF-alpha enhance in vitro growth of bacteria. Am. J. Respir. Crit. Care Med. 160, 961-967.
33. Milner S. M. and Ortega M. R. (1999) Reduced antimicrobial peptide expression in human burn wounds. Burns 25, 411-413.
34. Nakashima H., Yamamoto N., Masuda M. and Fujii N. (1993) Defensins inhibit HIV replication in vitro. AIDS 7, 1129.
35. Nakayama K., Okamura N., Arai H., Sekizawa K. and Sasaki H. (1999) Expression of human beta-defensin-1 in the choroid plexus. Ann. Neurol. 45, 685.
36. O'Neil D. A., Porter E. M., Elewaut D. G., Anderson M., Eckmann L., Ganz T. and Kagnoff M. F. (1999) Expression and regulation of the human beta-defensins HBD-1 and HBD-2 in intestinal epithelium. J. Immunol. 163, 6718-6724.
37. Okrent D. G., Lichtenstein A. K. and Ganz T. (1990) Direct cytotoxicity of polymorphonuclear leukocyte granule proteins to human lung-derived cells and endothelial cells. Am. Rev. Respir. Dis. 141, 179-185.
38. Ouellette A. J., Satchell D. P., Hsieh M. M., Hagen S. J. and Selsted M. E. (2000) Characterization of luminal paneth cell alpha-defensins in mouse small intestine. Attenuated antimicrobial activities of peptides with truncated amino termini. J. Biol. Chem. 27, 33969-33973.
39. Pong A. and Bradley J. S. (1999) Bacterial meningitis and the newborn infant. Infect. Dis. Clin. N. Am. 13, 711-733.
40. Prohaszka Z., Nemet K., Csermely P., Hudecz F., Mezo G. and Fust G. (1997) Defensins purified from human granulocytes bind C1q and activate the classical complement pathway like the transmembrane glycoprotein gp41 of HIV-1. Mol. Immunol. 34, 809-816.
41. Radermacher S. W., Schoop V. M. and Schluesener H. J. (1993) Bactenecin, a leukocytic antimicrobial peptide, is cytotoxic to neuronal and glial cells. J. Neurosci. Res. 15, 657-662.
42. Richardson M. (1996) Bacterial meningitis. Br. J. Hosp. Med. 5-18, 685-688.
43. Saukkonen K., Sande S., Cioffe C., Wolpe S., Sherry B., Cerami A. and Tuomanen E. (1990) The role of cytokines in the generation of inflammation and tissue damage in experimental Gram-positive meningitis. J. Exp. Med. 171, 439-448.
44. Schnapp D., Reid C. J., Harris A., Reid C. J. and Harris A. (1998) Localization of expression of human beta defensin-1 in the pancreas and kidney. J. Pathol. 186, 99-103.
45. Schnell L., Fearn S., Schwab M. E., Perry V. H. and Anthony D. C. (1999) Cytokine-induced acute inflammation in the brain and spinal cord. J. Neuropathol. Exp. Neurol. 58, 245-254.
46. Schroder J. M. and Harder J. (1999) Human beta-defensin-2. Int J. Biochem. Cell Biol. 31, 645-651.
47. Selsted M. E., Harwig S. S., Ganz T., Schilling J. W. and Lehrer R. I. (1985) Primary structures of three human neutrophil defensins. J. Clin. Invest. 76, 1436-1439.
48. Singh P. K., Jia H. P., Wiles K., Hesselberth J., Liu L., Conway B. A., Greenberg E. P., Valore E. V., Welsh M. J., Ganz T., Tack B. F. and McCray P. B. Jr (1998) Production of beta-defensins by human airway epithelia. Proc. Natl. Acad. Sci. USA 8, 14961-14966.
49. Stahel P. F., Shohami E., Younis F. M., Kariya K., Otto V. I., Lenzlinger P. M., Grosjean M. B., Eugster H. P., Trentz O., Kossmann T. and Morganti-Kossmann M. C. (2000) Experimental closed head injury: analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines. J. Cereb. Blood Flow Metab. 20, 369-380.
50. Tauber M. G., Sachdeva M., Kennedy S. L., Loetscher H. and Lesslauer W. (1992) Toxicity in neuronal cells caused by cerebrospinal fluid from pneumococcal and gram-negative meningitis. J. Infect. Dis. 166, 1045-1050.
51. Tsao N., Hsu H. P. and Lei H. Y. (1999) TNF-alpha-induced cyclooxygenase 2 not only increases the vasopermeability of blood-brain barrier but also enhances the neutrophil survival in Escherichia coli-induced brain inflammation. Prostaglandins Other Lipid Med. 57, 371-382.
52. Unhanand M., Musatafa M. M., McCracken G. H. and Nelson J. D. (1993) Gram-negative enteric bacillary meninitis: a 21 year experience. J. Pediatr. 122, 15-21.
53. Valore E. V., Martin E., Harwig S. S. and Ganz T. (1996) Intramolecular inhibition of human defensin HNP-1 by its propiece. J. Clin. Invest. 1, 1624-1629.
54. Valore E. V., Park C. H., Quayle A. J., Wiles K. R., McCray P. B. Jr and Ganz T. (1998) Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J. Clin. Invest. 15, 1633-1642.
55. Volpe J. J. (1995) Neurology of the Newborn, 3rd edn. WB Sanders, Philadelphia.
56. Yang G. Y., Gong C., Qin Z., Liu X. H. and Lorris Betz A. (1999) Tumor necrosis factor alpha expression produces increased blood-brain barrier permeability following temporary focal cerebral ischemia in mice. Brain Res. Mol. Brain Res. 21, 135-143.
57. Zucht H. D., Grabowsky J., Schrader M., Liepke C., Jurgens M., Schulz-Knappe P. and Forssmann W. G. (1998) Human beta-defensin-1: a urinary peptide present in variant molecular forms and its putative functional implication. Eur. J. Med. Res. 20, 315-323.