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Cloning and characterization of 5E6 (Ly-49C), a receptor molecule expressed on a subset of murine natural killer cells
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Definition of the H-2 specificity of the murine Ly-49C and Ly-49G2 (see [13]) receptors and evidence for allelic polymorphism of Ly-49C.
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Molecular clones of the p58 natural killer cell receptor reveal Ig-related molecules with diversity in both the extra- And intracellular domains
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Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO. Molecular clones of the p58 natural killer cell receptor reveal Ig-related molecules with diversity in both the extra- and intracellular domains. of outstanding interest Immunity. 2:1995;439-449 See annotation [18].
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Molecular cloning of NKB1: A natural killer cell receptor for HLA-B allotypes
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+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: Correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition
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The NKB1 and HP-3E4 NK cell receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules
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The human leukocyte antigen (HLA)-C-specific "activitory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions
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A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation
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Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells
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Moretta L, Sivori S, Vitale M, Pende D, Morelli L, Augugliaro R, Bottino C, Moretta L. Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells. J Exp Med. 182:1995;875-884.
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Moretta A, Vitale M, Sivori S, Bottino C, Morelli L, Augugliaro R, Barbaresi M, Pende D, Ciccone E, Lopez-Botet M, Moretta L. Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles. J Exp Med. 180:1994;545-555.
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CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, -B, and -C allotypes
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of outstanding interest. Evidence that CD94 forms disulfide-linked heterodimers that are involved in the recognition of HLA-A, -B, and -C allotypes.
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Phillips JH, Chang C, Mattson J, Gumperz JE, Parham P, Lanier LL. CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, -B, and -C allotypes. of outstanding interest Immunity. 5:1996;163-172 Evidence that CD94 forms disulfide-linked heterodimers that are involved in the recognition of HLA-A, -B, and -C allotypes.
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Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen
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of special interest. Demonstration that CD94 receptors are functionally heterogeneous and may inhibit or activate NK cell clones.
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Pérez-Villar JJ, Melero I, Rodriguez A, Carretero M, Aramburu J, Sivori S, Orengo AM, Moretta A, Lopez-Botet M. Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen. of special interest J Immunol. 154:1995;5779-5788 Demonstration that CD94 receptors are functionally heterogeneous and may inhibit or activate NK cell clones.
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A natural killer cell receptor specific for a major histocompatibility complex class I molecule
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0029859195
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The NK cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its MHC class I ligand
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of special interest. Further mapping of the H-2 specificity of the Ly-49 receptors and an indication that peptides are required to create the proper conformation for Ly-49 binding.
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Orihuela M, Margulies DH, Yokoyama WM. The NK cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its MHC class I ligand. of special interest Proc Natl Acad Sci USA. 93:1996;11792-11797 Further mapping of the H-2 specificity of the Ly-49 receptors and an indication that peptides are required to create the proper conformation for Ly-49 binding.
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d molecules on target cell protection and natural killer cell specificity in transgenic mice
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of special interest. Demonstration that only the extracellular domains of H-2 are necessary for Ly-49 function.
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d molecules on target cell protection and natural killer cell specificity in transgenic mice. of special interest Eur J Immunol. 26:1996;2127-2132 Demonstration that only the extracellular domains of H-2 are necessary for Ly-49 function.
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0029901736
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Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule
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of outstanding interest. An elegant study showing binding of KIR and HLA-C molecules in solution.
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Fan QR, Garboczi DN, Winter CC, Wagtmann N, Long EO, Wiley DC. Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule. of outstanding interest Proc Natl Acad Sci USA. 93:1996;7178-7183 An elegant study showing binding of KIR and HLA-C molecules in solution.
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Fan, Q.R.1
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0030027585
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Human natural killer cell inhibitory receptors bind to HLA class I molecules
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Dohring C, Colonna M. Human natural killer cell inhibitory receptors bind to HLA class I molecules. Eur J Immunol. 26:1996;365-369.
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Dohring, C.1
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41
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0028897989
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The Bw4 public epitope of HLA-B molecules confers reactivity with NK cell clones that express NKB1, a putative HLA receptor
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Gumperz JE, Litwin V, Phillips JH, Lanier LL, Parham P. The Bw4 public epitope of HLA-B molecules confers reactivity with NK cell clones that express NKB1, a putative HLA receptor. J Exp Med. 181:1995;1133-1144.
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Gumperz, J.E.1
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Phillips, J.H.3
Lanier, L.L.4
Parham, P.5
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42
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0027132097
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HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- And NK2-specific natural killer cells
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Colonna M, Borsellino G, Falco M, Ferrara GB, Strominger JL. HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells. Proc Natl Acad Sci USA. 90:1993;12000-12004.
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Colonna, M.1
Borsellino, G.2
Falco, M.3
Ferrara, G.B.4
Strominger, J.L.5
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43
-
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0029121541
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Single amino acid substitutions can influence the NK-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by "group 2" or "group 1" NK clones
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Biassoni R, Falco M, Cambiaggi A, Costa P, Verdiani S, Pende D, Conte R, DiDonato C, Parham P, Moretta L. Single amino acid substitutions can influence the NK-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by "group 2" or "group 1" NK clones. J Exp Med. 182:1995;605-610.
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J Exp Med
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Biassoni, R.1
Falco, M.2
Cambiaggi, A.3
Costa, P.4
Verdiani, S.5
Pende, D.6
Conte, R.7
Didonato, C.8
Parham, P.9
Moretta, L.10
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44
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0029932848
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A human killer inhibitory receptor specific for HLA-A
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Dohring C, Scheidegger D, Samaridis J, Cella M, Colonna M. A human killer inhibitory receptor specific for HLA-A. J Immunol. 156:1996;3098-3101.
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Dohring, C.1
Scheidegger, D.2
Samaridis, J.3
Cella, M.4
Colonna, M.5
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45
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0028933643
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General role of HLA class I molecules in the protection of target cells from lysis by natural killer cells: Evidence that the free heavy chains of class I molecules are not sufficient to mediate the protective effect
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Ciccone E, Pende D, Nanni L, Di Donato C, Viale O, Beretta A, Vitale M, Sivori S, Moretta A, Moretta L. General role of HLA class I molecules in the protection of target cells from lysis by natural killer cells: evidence that the free heavy chains of class I molecules are not sufficient to mediate the protective effect. Int Immunol. 7:1995;393-400.
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Int Immunol
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Ciccone, E.1
Pende, D.2
Nanni, L.3
Di Donato, C.4
Viale, O.5
Beretta, A.6
Vitale, M.7
Sivori, S.8
Moretta, A.9
Moretta, L.10
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46
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0028920065
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Peptide specificity in the recognition of MHC class I by natural killer cell clones
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of outstanding interest. The first evidence that peptides bound to HLA-27 influence recognition of MHC class I by NK cells.
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Malnati MS, Peruzzi M, Parker KC, Biddison WE, Ciccone E, Moretta A, Long EO. Peptide specificity in the recognition of MHC class I by natural killer cell clones. of outstanding interest Science. 267:1995;1016-1018 The first evidence that peptides bound to HLA-27 influence recognition of MHC class I by NK cells.
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Science
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, pp. 1016-1018
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-
Malnati, M.S.1
Peruzzi, M.2
Parker, K.C.3
Biddison, W.E.4
Ciccone, E.5
Moretta, A.6
Long, E.O.7
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47
-
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0028988327
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Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells
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of outstanding interest. A study indicating that either self or foreign peptides are sufficient for Ly-49 function.
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Correa I, Raulet DH. Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells. of outstanding interest Immunity. 2:1995;61-71 A study indicating that either self or foreign peptides are sufficient for Ly-49 function.
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(1995)
Immunity
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, pp. 61-71
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-
Correa, I.1
Raulet, D.H.2
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48
-
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0029902892
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*2705
-
of special interest. Formal proof that a single KIR-3D molecule can discriminate between peptides bound to HLA-B27.
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*2705. of special interest J Exp Med. 184:1996;1585-1590 Formal proof that a single KIR-3D molecule can discriminate between peptides bound to HLA-B27.
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(1996)
J Exp Med
, vol.184
, pp. 1585-1590
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-
Peruzzi, M.1
Wagtmann, N.2
Long, E.O.3
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49
-
-
0030587862
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*2705 by specific natural killer cells
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of special interest. Experiments demonstrating that residues seven and eight of peptides bound to HLA-B27 are important for KIR-3D recognition.
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*2705 by specific natural killer cells. of special interest J Immunol. 157:1996;3350-3356 Experiments demonstrating that residues seven and eight of peptides bound to HLA-B27 are important for KIR-3D recognition.
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(1996)
J Immunol
, vol.157
, pp. 3350-3356
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-
Peruzzi, M.1
Parker, K.C.2
Long, E.O.3
Malnati, M.S.4
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50
-
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0030047811
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CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase Cγ1 upon B cell activation
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Law C-L, Sidorenko SP, Chandran KA, Zhao Z, Shen S-H, Fischer EH, Clark EA. CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase Cγ1 upon B cell activation. J Exp Med. 184:1996;547-560.
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J Exp Med
, vol.184
, pp. 547-560
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Law, C.-L.1
Sidorenko, S.P.2
Chandran, K.A.3
Zhao, Z.4
Shen, S.-H.5
Fischer, E.H.6
Clark, E.A.7
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51
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0028932411
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Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by FcγRIIBI
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D'Ambrosio D, Hippen KL, Minskoff SA, Mellman I, Pani G, Siminovitch KA, Cambier JC. Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by FcγRIIBI. Science. 268:1995;293-297.
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Science
, vol.268
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D'Ambrosio, D.1
Hippen, K.L.2
Minskoff, S.A.3
Mellman, I.4
Pani, G.5
Siminovitch, K.A.6
Cambier, J.C.7
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52
-
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0030024788
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Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor
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of outstanding interest. The first report providing a molecular mechanism for KIR inhibition of NK-cell-mediated cytotoxicity.
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Burshtyn DN, Scharenberg AM, Wagtmann N, Rajagopalan S, Berrada K, Yi T, Kinet J-P, Long EO. Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. of outstanding interest Immunity. 4:1996;77-85 The first report providing a molecular mechanism for KIR inhibition of NK-cell-mediated cytotoxicity.
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(1996)
Immunity
, vol.4
, pp. 77-85
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-
Burshtyn, D.N.1
Scharenberg, A.M.2
Wagtmann, N.3
Rajagopalan, S.4
Berrada, K.5
Yi, T.6
Kinet, J.-P.7
Long, E.O.8
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53
-
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0008900035
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Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases
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of special interest. See annotation [55].
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Olcese L, Lang P, Vely F, Cambiaggi A, Marguet D, Blery M, Hippen KL, Biassoni R, Moretta A, Moretta L, et al. Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. of special interest J Immunol. 156:1996;4531-4534 See annotation [55].
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(1996)
J Immunol
, vol.156
, pp. 4531-4534
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-
Olcese, L.1
Lang, P.2
Vely, F.3
Cambiaggi, A.4
Marguet, D.5
Blery, M.6
Hippen, K.L.7
Biassoni, R.8
Moretta, A.9
Moretta, L.10
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54
-
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0030036615
-
Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C
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of special interest. See annotation [55].
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Campbell KS, Dessing M, Lopez-Botet M, Cella M, Colonna M. Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C. of special interest J Exp Med. 184:1996;93-100 See annotation [55].
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(1996)
J Exp Med
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-
Campbell, K.S.1
Dessing, M.2
Lopez-Botet, M.3
Cella, M.4
Colonna, M.5
-
55
-
-
0030037132
-
Phosphotyrosines in the KIR motif of NKB1 are required for negative signaling and for association with PTP1C
-
of special interest. This paper, along with [53,54], provides further support that SHP-1 is involved in inhibition of T and NK cell activation mediated by the human KIRs and murine Ly-49 receptors.
-
Fry A, Lanier LL, Weiss A. Phosphotyrosines in the KIR motif of NKB1 are required for negative signaling and for association with PTP1C. of special interest J Exp Med. 184:1996;295-300 This paper, along with [53,54], provides further support that SHP-1 is involved in inhibition of T and NK cell activation mediated by the human KIRs and murine Ly-49 receptors.
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(1996)
J Exp Med
, vol.184
, pp. 295-300
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Fry, A.1
Lanier, L.L.2
Weiss, A.3
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56
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0026629338
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Murine natural killer cells and marrow graft rejection
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Yu YYL, Kumar V, Bennett M. Murine natural killer cells and marrow graft rejection. Ann Rev Immunol. 10:1992;189-214.
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Ann Rev Immunol
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Yu, Y.Y.L.1
Kumar, V.2
Bennett, M.3
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57
-
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0030059047
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The role of Ly49A and 5E6 (Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts
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of special interest. Evidence that hybrid resistance to bone marrow allografts is mediated by inhibitory Ly-49 receptors.
-
Yu YYL, George T, Dorfman JR, Roland J, Kumar V, Bennett M. The role of Ly49A and 5E6 (Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts. of special interest Immunity. 4:1996;67-76 Evidence that hybrid resistance to bone marrow allografts is mediated by inhibitory Ly-49 receptors.
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(1996)
Immunity
, vol.4
, pp. 67-76
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-
Yu, Y.Y.L.1
George, T.2
Dorfman, J.R.3
Roland, J.4
Kumar, V.5
Bennett, M.6
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58
-
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0028912182
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Rejection of tumors in mice with severe combined immunodeficiency syndrome determined by the major histocompatibility complex. Class I expression on the graft
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Glas R, Waldenstrom M, Hoglund P, Klein G, Karre K, Ljunggren H-G. Rejection of tumors in mice with severe combined immunodeficiency syndrome determined by the major histocompatibility complex. Class I expression on the graft. Cancer Res. 55:1995;1911-1916.
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(1995)
Cancer Res
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, pp. 1911-1916
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Glas, R.1
Waldenstrom, M.2
Hoglund, P.3
Klein, G.4
Karre, K.5
Ljunggren, H.-G.6
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59
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0026054898
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Modulation of MHC antigen expression by viruses and oncogenes
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Maudsley DJ, Pound JD. Modulation of MHC antigen expression by viruses and oncogenes. Immunol Today. 12:1991;429-431.
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(1991)
Immunol Today
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Maudsley, D.J.1
Pound, J.D.2
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60
-
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0027933410
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T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function
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Ferrini S, Cambiaggi A, Meazza R, Sforzini S, Marciano S, Mingari MC, Moretta L. T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function. Eur J Immunol. 24:1994;2294-2298.
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(1994)
Eur J Immunol
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, pp. 2294-2298
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Ferrini, S.1
Cambiaggi, A.2
Meazza, R.3
Sforzini, S.4
Marciano, S.5
Mingari, M.C.6
Moretta, L.7
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61
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0029038380
-
Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes
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of outstanding interest. Demonstrates that KIR molecules can regulate T cell responses to super-antigens.
-
Phillips JH, Gumperz JE, Parham P, Lanier LL. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. of outstanding interest Science. 268:1995;403-405 Demonstrates that KIR molecules can regulate T cell responses to super-antigens.
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(1995)
Science
, vol.268
, pp. 403-405
-
-
Phillips, J.H.1
Gumperz, J.E.2
Parham, P.3
Lanier, L.L.4
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62
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0029834981
-
Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles
-
of special interest. Implicates KIRs in the regulation of cytokine production, as well as in cytotoxicity.
-
D'Andrea A, Chang C, Phillips JH, Lanier LL. Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. of special interest J Exp Med. 184:1996;789-794 Implicates KIRs in the regulation of cytokine production, as well as in cytotoxicity.
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(1996)
J Exp Med
, vol.184
, pp. 789-794
-
-
D'Andrea, A.1
Chang, C.2
Phillips, J.H.3
Lanier, L.L.4
-
63
-
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0030470555
-
Human NK cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits
-
of outstanding interest. Identification of the CD94-associated protein.
-
Lazetic S, Chang C, Houchins JP, Lanier LL, Philips JH. Human NK cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. of outstanding interest J Immunol. 157:1996;4741-4745 Identification of the CD94-associated protein.
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(1996)
J Immunol
, vol.157
, pp. 4741-4745
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-
Lazetic, S.1
Chang, C.2
Houchins, J.P.3
Lanier, L.L.4
Philips, J.H.5
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