Caspase-3 activity as a prognostic factor in colorectal carcinoma

Laboratory Investigation

Volumn 81, Issue 5, 2001, Pages 681-688

  Jonges, Liesbeth E ^a   Nagelkerke, J Fred ^b   Ensink, N Geeske ^a   Van Der Velde, Edo A ^a   Tollenaar, Rob A E M ^a   Fleuren, Gert Jan ^a   Van De Velde, Cornelis J H ^a   Morreau, Hans ^a   Kuppen, Peter J K ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CASPASE 3; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER RECURRENCE; COLORECTAL CARCINOMA; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR LOCALIZATION;

EID: 0034998192     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3780277     Document Type: Article

References (43)

1. Akiyama Y, Iwagana R, Ishakawa T, Sakamoto K, Nishi N, Nihei Z, Iwama T, Saitoh K, and Yuasa Y (1996). Mutations of the transforming growth factor-β type II receptor gene are strongly related to sporadic proximal colon carcinomas with microsatellite instability. Cancer 78:2478-2484.
2. Atkinson EA and Bleackley RC (1995). Mechanisms of lysis by cytotoxic T cells. Crit Rev Immunol 15:359-384.
3. Baretton GB, Diebold J, Christoforis G, Müller C, Dopfer K, Schneiderbanger K, Schmidt M, and Löhrs U (1996). Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas: Aspects of carcinogenesis and prognostic significance. Cancer 77:255-264.
4. Bedi A, Pasricha PJ, Akhtar AJ, Barber JP, Bedi GC, Giardiello FM, Zehnbauer BA, Hamilton SR, and Jones RJ (1995). Inhibition of apoptosis during development of colorectal cancer. Cancer Res 55:1811-1816.
5. Berke G (1995). Unlocking the secrets of CTL and NK cells, Immunol Today 16:343-346.
6. Blom WM, de Bont HJ, Meijerman I, Mulder GJ, and Nagelkerke JF (1999). Prevention of cycloheximide-induced apoptosis in hepatocytes by adenosine and by caspase inhibitors. Biochem Pharmacol 58:1891-1898.
7. Brabletz T, Jung A, Hermann K, Gunther K, Hohenberger W, and Kirchner T (1998). Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract 194:701-704.
8. Bradford MM (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
9. DeVisser KE and Kast WM (1999). Effects of TGF-β on the immune system: Implications for cancer immunotherapy. Leukemia 13:1188-1199.
10. DiGiorgio A, Botti C, Tocchi A, Mingazzini P, and Flammia M (1992). The influence of tumor lymphocytic infiltration on long tem survival of surgically treated colorectal cancer patients. Int Surg 77:260.
11. Dolcetti R, Viel A, Doglioni C, Russo A, Guidoboni M, Capozzi E, Vecciato N, Macri E, Fornasarig M, and Boiocchi M (1999). High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability. Am J Pathol 154:1805-1813.
12. Duke RC, Ojcius DM, and Ding-E Young J (1996). Cell suicide in health and disease. Sci Am 275:48-55.
13. Evertsson S, Bartik Z, Zhang H, Jansson A, and Sun XF (1999). Apoptosis in relation to proliferating cell nuclear antigen and Dukes' stage in colorectal adenocarcinoma. Int J Oncol 15:53-58.
14. Famularo G, De Simone C, Tzantzoglou S, and Trinchieri V (1994). Apoptosis, anti-apoptotic compounds and TNF-α release. Immunol Today 15:495-496.
15. Green DR and Martin SJ (1995). The killer and the executioner: How apoptosis controls malignancy. Curr Opin Immunol 7:694-703.
16. Gryfe R, Hyeja K, Hsieh ETK, Aronson MD, Holowaty EJ, Bull SB, Redston M, and Gallinger S (2000). Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med 342:69-77.
17. Gryfe R, Swallow C, Bapat B, Redston M, Gallinger S, and Couture J (1997). Molecular biology of colorectal cancer. Curr Probl Cancer 21:233-300.
18. Gunther K, Brabletz T, Kraus C, Dworak O, Reymond MA, Jung A, Hohenberger W, Kirchner T, Kockerling F, and Ballhausen WG (1998). Predictive value of nuclear beta-catenin expression for the occurrence of distant metastases in rectal cancer. Dis Colon Rectum 41:1256-1261.
19. Hahne M, Rimoldi D, Schroter M, Romero P, Schreier M, French LE, Schneider P, Bornand T, Fontana A, Lienard D, Cerottini J, and Tschopp J (1996). Melanoma cell expression of Fas(Apo-1/CD95) ligand: Implications for tumor immune escape (see comments). Science 274:1363-1366.
20. Hashimoto S, Koji T, Kohara N, Kanematsu T, and Nakane PK (1997). Frequency of apoptosis relates inversely to invasiveness and metastatic activity in human colorectal cancer. Virchows Arch 431:241-248.
21. Hawkins N, Lees J, Hargrave R, O'Connor T, Meagher A, and Ward R (1997). Pathological and genetic correlates of apoptosis in the progression of colorectal neoplasia. Tumour Biol 18:146-156.
22. Ilyas M, Straub J, Tomlinson IPM, and Bodmer WF (1999). Genetic pathways in colorectal and other cancers. Eur J Cancer 35:335-351.
23. Ito Y, Matsuura N, Sakon M, Takeda T, Umeshita K, Nagano H, Nakamori S, Tsujimoto M, Nakahara M, Nakao K, and Monden M (1999). Both cell proliferation and apoptosis significantly predict shortened disease-free survival in hepatocellular carcinoma. Br J Cancer 81:747-751.
24. Jass JR (1986). Lymphocytic infiltration and survival in rectal cancer. J Clin Pathol 39:585-589.
25. Jass JR (1999). Towards a molecular classification of colorectal cancer, Int J Colorectal Dis 14:194-200.
26. Kane MF, Loda M, Gaida GM, Lipman J, Mishra R, Goldman H, Jessup JM, and Kolodner R (1997). Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 57:808-811.
27. Kaserer K, Schmaus J, Bethge U, Migschitz B, Fasching S, Walch A, Herbst F, Teleky B, and Wrba F (2000). Staining patterns of p53 immunohistochemistry and their biological significance in colorectal cancer. J Pathol 190:450-456.
28. Kawasaki H, Altieri DC, Lu CD, Toyoda M, Tenjo T, and Tanigawa N (1998). Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer. Cancer Res 58:5071-5074.
29. Langlois NEI, Lamb J, Eremin O, and Heys SD (1997). Apoptosis in colorectal carcinoma occuring in patients aged 45 years and under: Relationship to prognosis, mitosis and immunohistochemical demonstration of p53, c-myc and bcl-2 protein products. J Pathol 182:392-397.
30. Loeb LA (1994). Microsattelite instability: Marker of a mutator phenotype in cancer. Cancer Res 54:5059-5063.
31. Lothe RA (1997). Microsattelite instability in human solid tumors. Mol Med Today 2:61-68.
32. Markowitz S, Wang J, Myerhoff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain MG, and Willson JKV (1995). Inactivation of the type II TGF-β receptor in colon cancer cells with microsattelite instability. Science 268:1336-1338.
33. Naito Y, Saito K, Shiiba K, Ohuchi A, Saigenji K, Nagura H, and Ohtani H (1998). CDS+ T cells infiltrated within cancer cells nests as a prognostic factor in human colorectal cancer. Cancer Res 58:3491-3494.
34. O'Connell J, O'Sullivan GC, Collins JK, and Shanahan F (1996). The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand. J Exp Med 184: 1075-1082.
35. Rafter J and Glinghammar B (1998). Interactions between the environment and genes in the colon. Eur J Cancer Prev(7 Suppl 2):S69-S74.
36. Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, and Kosma VM (1997). Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J Pathol 182:318-324.
37. Sobin LH and Wittekind Ch (1997). Colon and rectum. In: Hermanek P, Hutter RVP, Sobin LH, Wagner G, and Wittekind Ch, editors. TNM Atlas: Illustrated guide to the TNM/pTNM classification of malignant tumors. New York: Springer, 98-106.
38. Sugamura K, Makino M, and Kaibara N (1998). Apoptosis as a prognostic factor in colorectal carcinoma. Surg Today 28:145-150.
39. Svennevig JL, Lunde OC, Holter J, and Bjorgsvik D (1984). Lymphoid infiltration and prognosis in colorectal carcinoma. Br J Cancer 49:375-377.
40. Tompson CB (1995). Apoptosis in the pathogenesis and treatment of disease. Science 267:386-401.
41. Tsujitani S, Shirai H, Tatebe S, Sugamura K, Ohfuji S, Gomyo Y, Maeta M, Ito H, and Kaibara N (1996). Apoptotic cell death and its relationship to carcinogenesis in colorectal carcinoma. Cancer 77:1711-1716.
42. Warren HS and Smyth MJ (1999). NK cells and apoptosis. Immunol Cell Biol 77:64-75.
43. Watson DS, Brotherick I, Shenton BK, Wilson RG, and Campbell FC (1999). Growth dysregulation and p53 accumulation in human primary colorectal cancer. Br J Cancer 80:1062-1068.