Expression of the E-cadherin-catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases

British Journal of Cancer

Volumn 75, Issue 10, 1997, Pages 1474-1480

  Andrews, N A ^a   Jones, A S ^a   Helliwell, T R ^a   Kinsella, A R ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Cell adhesion; E cadherin complex; Metastasis; Squamous cell carcinoma of the head and neck

Indexed keywords

CATENIN; UVOMORULIN;

ARTICLE; CELL ADHESION; COLON MUCOSA; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL; SQUAMOUS CELL CARCINOMA; SQUAMOUS EPITHELIUM;

EID: 0030898075     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.252     Document Type: Article

References (45)

1. Aberle H, Butz S, Stappert J, Weissig H, Kemler R and Hoschuetzky H (1994) Assembly of the cadherin-catenin complex in vivo with recombinant proteins. J Cell Sci 107: 3655-3663
2. Armitage P and Berry G (1987) Survival Analysis. In Statistical Methods in Medical Research, 2nd edn, Armitage P and Berry G (eds), pp. 408-410. Blackwell Scientific Publications: Oxford
3. Birchmeier W, Weidner KM, Hulsken J and Behrens J (1993) Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas. Semin Cancer Biol 4: 231-239
4. Bloom HJG (1984) Head and Neck Oncology, pp. 6-8. Raven Press: New York
5. Bringuier PP, Umbas R and Schaafsma HE (1993) Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumours. Cancer Res 53: 3241-3245
6. Bowie GL, Caslin AW, Roland NJ, Field JK, Jones AS and Kinsella AR (1993) Expression of the cell-cell adhesion molecule E-cadherin in squamous cell carcinoma of the head and neck. Clin Otolaryngol 18: 196-201
7. Cachin Y (1975) Cancer of the head and neck: Prognostic criteria in response to treatment. pp. 353-366. Raven Press: New York
8. Ewing CM, Ru N and Morton RA (1995) Chromosome 5 suppresses the tumourgenicity of PC3 prostate cancer cells: correlation with re-expression of α-catenin and restoration of E-cadherin function. Cancer Res 55: 4813-4817
9. Frixen UH, Behrens J, Sachs M, Eberle G, Voss B and Warda AE (1991) Cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113: 173-185
10. Gagliardi G, Kandemir O, Liu D, Guida M, Benvestito S and Ruers TGM (1995) Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large-bowel. Virchows Archiv 426: 149-154
11. Hermanek P and Sobin LH (eds) (1992) UICC TNM Classification of Malignant Tumours. 4th edn. 2nd rev. Springer: Berlin
12. Hibbert J, Marks MJ, Winter PJ and Shaheen OH (1993) Prognostic factors in oral squamous carcinomas and relation to clinical staging. Clin Otolaryngol 8: 197-203
13. Hoffman S and Edelman GM (1983) Kinetics of homophilic binding by embryonic and adult forms of neural cell adhesion molecules. Proc Natl Acad Sci USA 80: 5762-5766
14. Hudson DL, Weiland KL, Dooley TP, Simon M and Watt FM (1992) Characterisation of eight monoclonal antibodies to involucrin. Hybridoma 11: 367-371
15. Hulsken J, Birchmeier W and Behrens J (1994) E-cadherin and apc compete for the interaction with β-catenin and the cytoskeleton. J Cell Biol 127: 2061-2069
16. Jones AS, Cook JA, Phillips DE and Roland NJ (1993) Squamous carcinomas presenting as an enlarged cervical lymph node. Cancer 72: 1756-1761
17. Kawanishi J, Kato J, Sasaki K, Fujii S, Watanabe N and Niitsu Y (1995) Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the β-catenin gene in a human cancer cell-line, hsc-39. Mol Cell Biol 15: 1175-1181
18. Kinsella AR, Green B, Lepts GC, Hill CL, Bowie G and Taylor BA (1993) The role of cell cell adhesion E-cadherin in large bowel tumour cell invasion and metastases. Br J Cancer 67: 904-909
19. Kinsella AR, Lepts GC, Hill CL and Jones M (1994) Reduced E-cadherin expression correlated with increased invasiveness in colorectal-carcinoma cell-lines. Clin Exp Metast 12: 335-342
20. Kinsella AR, Bowie GL, Field JK and Jones AS (1994b) Expression of cell-cell adhesion molecule E-cadherin in tongue carcinoma cell-lines. Laryngol Otol 108: 957-961
21. Knusden KA, Soler AP, Johnson KR and Wheelock MJ (1995) Interaction of alpha-actinin with the cadherin catenin cell-cell adhesion complex via α-catenin. J Cell Biol 130: 67-77
22. Liotta L, Wewer U, Rao NC, Schiffmann E, Strach EM, Guirguis R and Thorgeirsson U (1988) Biochemical mechanisms of tumour invasion and metastasis: Advances in pigment cell research, pp. 3-16. Klumer Academic Publications: The Netherlands
23. Matsui S, Shiozaki H, Inoue M and Tamrura S (1994) Immunohistochemical evaluation of α-catenin expression in human gastric cancer. Virchows Arch 424: 375-381
24. Mattijssen V, Peters H and Schalkwijk L (1993) E-cadherin expression in head and neck squamous cell carcinomas is associated with clinical outcome. Int J Cancer 55: 580-585
25. Mayor B, Johnson JP, Leitl F, Jauch KW, Heiss MM and Schildberg FW (1993) E-cadherin expression in primary and metastatic gastric cancer - down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res 53: 1690-1695
26. McCrea PD, Turck WC and Gumbiner B (1991) A homologue of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Science 254: 1359-1361
27. Norton AJ (1993) Microwave oven heating for antigen unmasking in routinely processed tissue sections. J Pathol 171: 79-80
28. Ochia A, Akimoto S, Shimoyama Y, Nagafuchi A, Tsukita S and Hirohashi S (1994) Frequent loss of α-catenin expression in scirrhous carcinomas with scattered cell growth. Jpn J Cancer Res 85: 266-273
29. Oka H, Shiozaki H, Kobayashi K, Inoue M, Tahara H and Kohayashi T (1993) Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res 53: 1696-1701
30. Oyama T, Kanai Y, Ochiai A, Akimoto S, Oda T and Yanagihara K (1994) Truncated β-catenin disrupts the interaction between E-cadherin and α-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res 54: 6282-6287
31. Ozawa M and Kemler R (1992) Molecular organisation of the uvomorulin-catenin complex. J Cell Biol 116: 989-996
32. Peto R, Pike MC and Armitage P (1977) Design and analysis of randomised clinical trials requiring prolonged observation of each subject. Br J Cancer 35: 1-39
33. Pignatelli M, Ansari TW, Gunter P, Liu D, Hirano S and Takeichi M (1994) Loss of membranous E-cadherin expression in pancreatic-cancer - correlation with lymph-node metastasis, high-grade, and advanced-stage. J Pathol 174: 243-248
34. Ponta H, Hoffman M and Herrlich P (1994) Recent advances in the genetics of metastasis. Eur J Cancer 13: 1995-2001
35. Rubinfeld B, Souza B, Alhoi I and Muller O (1993) Association of the APC gene product with β-catenin. Science 262: 1731-1734
36. SAS Institute (1985) User's Guide: Statistics Version, 5th edn. SAS Institute: Cary, North Carolina
37. Schalken JA, Bringuier PP, Unbas R, Schaafsma HE, Karthaus HFM and Debruyne FMJ (1993) Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumours. Cancer Res 53: 3241-3245
38. Schipper JH, Frixen UH, Behrens J, Unger A, Jahnke K and Birchmeier W (1991) E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 51: 6328-6337
39. Shimoyama Y, Nagafuchi A, Fujita S, Gotoh M, Takeichi M and Tsukita S (1992) Cadherin dysfunction in a human cancer cell-line - possible involvement of loss of α-catenin expression in reduced cell-cell adhesiveness. Cancer Res 52: 5770-5774
40. Stappert J and Kemler R (1994) A short core region of E-cadherin is essential for catenin binding and is highly phosphorylated. Cell Adhes Commun 2: 319-327
41. Su LK, Vogelstein B and Kinzler KW (1993) Association of the APC tumour suppressor protein with the catenins. Science 262: 1734-1737
42. Takechi M (1991) Cadherin cell adhesion receptors as a morphological regulator. Science 251: 1451-1455
43. Umbas R, Schalken JA and Alders TW (1992) Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high grade prostatic cancer. Cancer Res 52: 5104-5109
44. Vermeulen S, Bruyneel EA and Bracke M (1995) Transition from the non-invasive to the invasive phenotype and loss of α-catenin in human colon cell lines Cancer Res 55: 4722-4728
45. Zubrod CG, Schneiderman M and Frei E (1960) Appraisal of methods for the study ot chemotherapy of cancer in man: comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide. J Chron Dis 11: 31-37