Coexpression of guanylate kinase with thymidine kinase enhances prodrug cell killing in vitro and suppresses vascular smooth muscle cell proliferation in vivo

Molecular Therapy

Volumn 3, Issue 5, 2001, Pages 779-786

  Akyürek, Levent M ^a   Nallamshetty, Shriram ^a   Aoki, Kazunori ^a   San, Hong ^a   Yang, Zhi Yong ^a   Nabel, Gary J ^a   Nabel, Elizabeth G ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Acyclovir; Ganciclovir; Thymidine kinase; Vascular smooth muscle cells

Indexed keywords

ELONGATION FACTOR 1ALPHA; GANCICLOVIR; GUANYLATE KINASE; PRODRUG; THYMIDINE KINASE; VIRUS VECTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTERY; ARTERY INTIMA; ARTERY MEDIA; ARTICLE; BLOOD VESSEL INJURY; CARDIOVASCULAR DISEASE; CELL KILLING; CELL PROLIFERATION; CONTROLLED STUDY; CYTOMEGALOVIRUS; DOSE RESPONSE; DRUG EFFICACY; DRUG EXPOSURE; GENE CONSTRUCT; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PROMOTER REGION; STENT; VASCULAR SMOOTH MUSCLE; VIRUS GENE;

ANIMALIA; CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; HERPES; SIMPLEXVIRUS; SUS SCROFA;

EID: 0034989201     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2001.0315     Document Type: Article

References (33)

1. Gene therapy for vascular smooth muscle cell proliferation after arterial injury
2. In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene
3. Regulation of cellular proliferation and intimal formation following balloon injury in atherosclerotic rabbit arteries
4. The purine path to chemotherapy
5. Cloning, characterization, and modeling of mouse and human guanylate kinases
6. Efficient generation of recombinant adenoviral vectors by Cre-lox recombination in vitro
7. PEF-BOS, a powerful mammalian expression vector
8. The first intron of the 4F2 heavy-chain gene contains a transcriptional enhancer element that binds multiple nuclear proteins
9. Initiation of protein synthesis by internal entry of ribosomes into the 5′ nontranslated region of encephalomyocarditis virus RNA in vivo
10. Combination gene delivery of the cell cycle inhibitor p27 with thymidine kinase enhances prodrug cytotoxicity
11. Detection of wild-type contamination in a recombinant adenoviral preparation by PCR
12. The NIR stent, transforming geometry
13. Purine metabolism in primitive erythrocytes
14. Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase
15. Site-specific gene expression in vivo by direct gene transfer into the arterial wall
16. 'Bystander killing' induces apoptosis and is inhibited by forskolin
17. Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo
18. Multicomponent gene therapy vaccines for lung cancer: Effective eradication of established murine tumors in vivo with interleukin-7/herpes simplex thymidine kinase-transduced autologous tumor and ex vivo activated dendritic cells
19. Local and systemic antitumor response after combined therapy of mouse metastatic tumors with tumor cells expressing IFN-alpha and HSVtk: Perspectives for the generation of cancer vaccines
20. Enhancement of tumor killing using a combination of tumor immunization and HSV-tk suicide gene therapy
21. Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy
22. The pathogenesis of atherosclerosis: A perspective for the 1990s
23. SM22α promoter targets gene expression to vascular smooth muscle cells in vitro and in vivo
24. Transcriptional targeting of replication-defective adenovirus transgene expression to smooth muscle cells in vivo
25. Dealing with in-stent restenosis
26. Inhibition of neointimal proliferation with low-dose irradiation from a beta-particle-emitting stent
27. Coated stents: Local pharmacology
28. Passivation of metallic stents after arterial gene transfer of phVEGF165 inhibits thrombus formation and intimal thickening
29. Retroviral suicide vector does not inhibit neointimal growth in a porcine coronary model of restenosis
30. Acyclovir-induced neurotoxicity: Concentration-side effect relationship in acyclovir overdose
31. Nephrotoxicity of antiviral therapies
32. Ventricular tachycardia in two patients with AIDS receiving ganciclovir (DHPG)
33. Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system