SM22α Promoter Targets Gene Expression to Vascular Smooth Muscle Cells In Vitro and In Vivo

Molecular Medicine

Volumn 6, Issue 11, 2000, Pages 983-991

  Akyürek, Levent M ^a   Yang, Zhi Yong ^a,b   Aoki, Kazunori ^b   San, Hong ^a   Nabel, Gary J ^b   Parmacek, Michael S ^c   Nabel, Elizabeth G ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Adenoviral Vector; Chloramphenicol Transferase (CAT); Human Placental Alkaline Phosphatase; SM22 Promoter; Vascular SMCs

Indexed keywords

ACTIN BINDING PROTEIN; MUSCLE PROTEIN; SM 22 MUSCLE PROTEIN; TAGLN PROTEIN, MOUSE;

ANIMAL; ARTICLE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; PROMOTER REGION; VASCULAR SMOOTH MUSCLE;

ANIMALS; GENE EXPRESSION REGULATION; MICE; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; PROMOTER REGIONS (GENETICS);

MLCS; MLOWN;

EID: 0034326692     PISSN: 10761551     EISSN: 15283658     Source Type: Journal    
DOI: 10.1007/BF03401832     Document Type: Article

References (24)

1. R. Ross The pathogenesis of atherosclerosis: a perspective for the 1990s Nature 1993 362 801 809 10.1038/362801a0 1:CAS:528:DyaK3sXktVGqu7c%3D 8479518
2. E.G. Nabel G. Plautz G.J. Nabel Site-specific gene expression in vivo by direct gene transfer into the arterial wall Science 1990 249 1285 1288 10.1126/science.2119055 1:CAS:528:DyaK3cXlvVGrurY%3D 2119055
3. S.M. Schwartz D. deBlois E.R. O’Brien The intima. Soil for atherosclerosis and restenosis Circ. Res. 1995 77 445 465 10.1161/01.RES.77.3.445 1:CAS:528:DyaK2MXns1altrs%3D 7641318
4. K. Sobue K. Hayashi W. Nishida Expressional regulation of smooth muscle cell-specific genes in association with phenotypic modulation Mol. Cell Biochem. 1999 190 105 118 10.1023/A:1006941621170 1:CAS:528:DyaK1MXisVyks7k%3D 10098977
5. L. Li J.M. Miano P. Cserjesi E.N. Olson SM22α, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis Circ. Res. 1996 78 188 195 10.1161/01.RES.78.2.188 1:CAS:528:DyaK28XnsFyiuw%3D%3D 8575061
6. J. Solway J. Seltzer F.F. Samaha et al. Structure and expression of a smooth muscle cell-specific gene, SM22α J. Biol. Chem. 1995 270 13460 13469 10.1074/jbc.270.22.13460 1:CAS:528:DyaK2MXmtV2hs7g%3D 7768949
7. L. Li J.M. Miano B. Mercer E.N. Olson Expression of the SM22α promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells J. Cell Biol. 1996 132 849 859 10.1083/jcb.132.5.849 1:CAS:528:DyaK28XhsFahurk%3D 8603917
8. H. Moessler M. Mericskay Z. Li S. Nagl D. Paulin J.V. Small The SM22 promoter directs tissue-specific expression in arterial but not in venous or visceral smooth muscle cells in transgenic mice Development 1996 122 2415 2425 8756287 1:CAS:528:DyaK28XltFWnt7k%3D
9. S. Kim H.S. Ip M.M. Lu C. Clendenin M.S. Parmacek A serum response factor-dependent transcriptional regulatory program identifies distinct smooth muscle cell sublineages Mol. Cell Biol. 1997 17 2266 2278 10.1128/MCB.17.4.2266 1:CAS:528:DyaK2sXhvFOhsL4%3D 9121477 232076
10. B.A. Karpinski L.H. Yang P. Cacheris G.D. Morle J.M. Leiden The first intron of the 4F2 heavy-chain gene contains a transcriptional enhancer element that binds multiple nuclear proteins Mol. Cell Biol. 1989 9 2588 2597 10.1128/MCB.9.6.2588 1:CAS:528:DyaL1MXktlCmsbg%3D 2761540 362331
11. R.D. Sihmari Z.Y. Yang X. Ling et al. Requirements for enhanced transgene expression by untranslated sequences from the human cytomegalovirus immediate-early gene Mol. Med. 1998 4 700 706 10.1007/BF03401764
12. K. Aoki C. Barker X. Danthinne M.J. Imperiale G.J. Nabel Efficient generation of recombinant adenoviral vectors by Cre-lox recombination in vitro Mol. Med. 1999 5 224 231 10448644 2230325 1:CAS:528:DyaK1MXktFShtLw%3D 10.1007/BF03402119
13. T. Ohno D. Gordon H. San et al. Gene therapy for vascular smooth muscle cell proliferation after arterial injury Science 1994 265 781 784 10.1126/science.8047883 1:CAS:528:DyaK2cXlsVyks74%3D 8047883
14. W.W. Zhang P.E. Koch J.A. Roth Detection of wild-type contamination in a recombinant adenoviral preparation by PCR Biotechniques 1995 18 444 447 7779393 1:CAS:528:DyaK2MXktFGqu7w%3D
15. A. Ayme-Southgate R. Southgate J. Saide G.M. Benian M.L. Pardue Both synchronous and asynchronous muscle isoforms of projectin (the Drosophila bent locus product) contain functional kinase domains J. Cell Biol. 1995 128 393 403 10.1083/jcb.128.3.393 1:CAS:528:DyaK2MXjt1Cju7c%3D 7844153
16. B. Camoretti-Mercado S.M. Forsythe M.M. LeBeau et al. Expression and cytogenetic localization of the human SM22 gene (TAGLN) Genomics 1998 49 452 457 10.1006/geno.1998.5267 1:CAS:528:DyaK1cXjtlyksbo%3D 9615232
17. C.M. Shanahan P.L. Weissberg J.C. Metcalfe Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells Circ. Res. 1993 73 193 204 10.1161/01.RES.73.1.193 1:CAS:528:DyaK3sXmtFylu7Y%3D 8508530
18. P.R. Kemp J.K. Osbourn D.J. Grainger J.C. Metcalfe Cloning and analysis of the promoter region of the rat SM22α gene Biochem. J. 1995 310 1037 1043 10.1042/bj3101037 1:CAS:528:DyaK2MXot1aku74%3D 7575400 1135999
19. A. Zilberman V. Dave J. Miano E.N. Olson M. Periasamy Evolutionarily conserved promoter region containing CArG*-like elements is crucial for smooth muscle myosin heavy chain gene expression Circ. Res. 1998 82 566 575 10.1161/01.RES.82.5.566 1:CAS:528:DyaK1cXitVSktb8%3D 9529161
20. C.P. Mack M.M. Thompson S. Lawrenz-Smith G.K. Owens Smooth muscle α-actin CArG elements coordinate formation of a smooth muscle cell-selective, serum response factor-containing activation complex Circ. Res. 2000 86 221 232 10.1161/01.RES.86.2.221 1:CAS:528:DC%2BD3cXht1Cktrg%3D 10666419
21. C.S. Madsen C.P. Regan J.E. Hungerford S.L. White I. Manabe G.K. Owens Smooth muscle-specific expression of the smooth muscle myosin heavy chain gene in transgenic mice requires 5′-flanking and first intronic DNA sequence Circ. Res. 1998 82 908 917 10.1161/01.RES.82.8.908 1:CAS:528:DyaK1cXivVWqu7g%3D 9576110
22. S. Kim H. Lin E. Barr L. Chu J.M. Leiden M.S. Parmacek Transcriptional targeting of replication-defective adenovirus transgene expression to smooth muscle cells in vivo J. Clin. Invest. 1997 100 1006 1014 10.1172/JCI119611 1:CAS:528:DyaK2sXlvFOgs7w%3D 9276717 508275
23. C.M. Shananhan N.R.B. Cary J.C. Metcalfe P.L. Weissberg High expression of genes for calcification-regulating proteins in human atherosclerotic plaques J Clin Invest 1994 93 2393 2402 10.1172/JCI117246
24. K. Aoki L.M. Akyürek H. San et al. Restricted expression of an adenoviral vector encoding Fas ligand (CD95L) enhances safety for cancer gene therapy Mol. Therapy 2000 1 555 565 10.1006/mthe.2000.0076 1:CAS:528:DC%2BD38XhvF2htrg%3D