Regulation of cellular proliferation and intimal formation following balloon injury in atherosclerotic rabbit arteries

Journal of Clinical Investigation

Volumn 98, Issue 1, 1996, Pages 225-235

  Simari, Robert D ^a   San, Hong ^a   Rekhter, Mark ^a   Ohno, Takeshi ^c   Gordon, David ^a   Nabel, Gary J ^a,b   Nabel, Elizabeth G ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c NONE

Author keywords

adenoviral vectors; gene transfer; macrophages; smooth muscle cells; thymidine kinase

Indexed keywords

ALKALINE PHOSPHATASE; GANCICLOVIR; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTERY INJURY; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE TRANSFER; HISTOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; RABBIT; RECOMBINANT GENE; REGULATOR GENE;

EID: 0030035247     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118770     Document Type: Article

References (43)

1. Ross, R. 1993. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (Lond.). 362:801-809.
2. Gibbons, G.H., and V.J. Dzau. 1994. The emerging concept of vascular remodeling. N. Engl. J. Med. 330:1431-1438.
3. Libby, P. 1995. Molecular bases of the acute coronary syndromes. Circulation. 91:2844-2850.
4. Ohno, T., D. Gordon, H. San, V.J. Pompili, M.J. Imperiale, G.J. Nabel, and E.G., Nabel. 1994. Gene therapy for vascular smooth muscle cell proliferation after arterial injury. Science (Wash. DC). 265:781-784.
5. Guzman, R.J., E.A. Hirschowitz, S.L. Brody, R.G. Crystal, S.E. Epstein, and T. Finkel. 1994. In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of herpes simplex thymidine kinase gene. Proc. Natl. Acad. Sci. USA. 91:10732-10736.
6. Chang, M.W., T. Ohno, D. Gordon, M.M. Lu, G.J. Nabel, E.G. Nabel, and J.M. Leiden. 1995. Adenovirus-mediated transfer of the herpes virus simplex virus thymidine kinase gene inhibits vascular smooth muscle cell proliferation and neointima formation following balloon angioplasty of the rat carotid artery. Mol. Med. 1:172-181.
7. Chang, M.W., E. Barr, J. Seltzer, J.-Q. Jiang, G.J. Nabel, E.G. Nabel, M.S. Parmacek, and J.M. Leiden. 1994. Cytostatic gene therapy for vascular proliferative disorders using a constitutively active form of Rb. Science (Wash. DC). 267:518-522.
8. Indolfi, C., E.V. Avvedimento, A. Rapacciuolo, E. Di Lorenzo, G. Esposito, E. Stabile, A. Feliciello, E. Mele, P. Guiliano, G. Condorelli, et al. 1995. Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo. Nature Medicine. 1:541-545.
9. Gordon, J.W., G.A. Scangos, D.J. Plotkin, J.A. Barbosa, and F.H. Ruddle. 1980. Genetic transformation of mouse embryos by microinjection of purified DNA. Proc. Natl. Acad. Sci. USA. 77:7380-7384.
10. Borrelli, E.R., R. Heyman, M. Hsi, and R.M. Evans. 1988. Targeting of an inducible toxic phenotype in animal cells. Proc. Natl. Acad. Sci. USA. 85: 7572-7576.
11. Culver, K.W., Z. Ram, S. Wallbridge, H. Ishii, E.H. Oldfield, and R.M. Blaese. 1992. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science (Wash. DC). 256:1550-1552.
12. Chen, S.H., H.D. Shine, J.C. Goodman, R.G. Grossman, and S.L.C. Woo. 1994. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc. Natl. Acad. Sci. USA. 91: 3054-3057.
13. Feldman, L.J., P.G. Steg, L.P. Zheng, D. Chen, M. Kearney, S.E. McGarr, J.J. Barry, J.-F. Dedieu, M. Perricaudet, and J.M. Isner. 1995. Low-efficiency of percutaneous adenovirus-mediated arterial gene transfer in the atherosclerotic rabbit. J. Clin. Invest. 95:2662-2671.
14. French, B.A., W. Mazur, N.M. Ali, R.S. Geske, J.P. Finnigan, G.P. Rodgers, R. Roberts, A.E. Raizner. 1994. Percutaneous transluminal in vivo gene transfer by recombinant adenovirus in normal porcine coronary arteries, atherosclerotic arteries, and two models of coronary restenosis. Circulation. 90: 2403-2413.
15. Muller, D.W.M., D. Gordon, H. San, Z.Y. Yang, V.J. Pompili, G.J. Nabel, and E.G. Nabel. 1994. Catheter-mediated pulmonary vascular gene transfer and expression. Circ. Res. 75:1039-1049.
16. Isik, F.F., T.O. McDonald, M. Ferguson, E. Yamanaka, and D. Gordon. 1992. Transplant arteriosclerosis in a rat aortic model. Am. J. Pathol. 141:1139-1149.
17. Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:55-63.
18. Gonchoroff, N.J., J.A. Katzman, R.M. Currie, E.L. Evans, D.W. Houck, B.C. Kline, P.R. Greipp, and M.R. Loken. 1986. S-phase detection with an antibody to bromodeoxyuridine. Role of DNase pretreatment. J. Immunol. Methods. 93:97-101.
19. Tsukada, T., M.E. Rosenfeld, R. Ross, A.M. Gown. 1986. Immunocytochemical analysis of cellular components in lesions of atherosclerosis in Watanabe and fat-fed rabbits using monoclonal antibodies. Arteriosclerosis. 6:601-613.
20. Faxon, D.P., T.A. Sanborn, V.J. Wever, C.C. Haudenschild, S.B. Gottsman, W.A. McGovern, and T.J. Ryan. 1984. Restenosis following transluminal angioplasty in experimental atherosclerosis. Arteriosclerosis. 4:189-195.
21. Gellman, J., M.D. Ezekowitz, I.J. Sarembock, M.A. Azrin, L.E. Nochomowitz, E. Lerner, and C.C. Haudenschild. 1991. Effect of lovastatin on intimai hyperplasia after balloon angioplasty: a study in an atherosclerotic hypercholesterolemic rabbit. J. Am. Coll. Cardiol. 17:251-259.
22. Hanke, H., T. Strohschneider, M. Oberhoff, E. Betz, and K.R. Karsch. 1990. Time course of smooth muscle cell proliferation in the intima and media of arteries following experimental angioplasty. Circ. Res. 67:651-659.
23. Sarembock, I.J., P.J. LaVeau, S.L. Sigal, I. Timms, J. Sussman, C.C. Haudenschild, and M.D. Ezekowitz. 1989. Influence of inflation pressure and balloon size on the development of intimai hyperplasia after balloon angioplasty. A study in the atherosclerotic rabbit. Circulation. 80:1029-1040.
24. Nabel, E.G., D. Gordon, Z.-Y. Yang, L. Xu, H. San, G.E. Plautz, B.-Y. Wu, X. Gao, L. Huang, and G.J. Nabel. 1992. Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization. Hum. Gene Ther. 3:649-656.
25. Simons, M., E.R. Edelman, J.L. DeKeyser, R. Langer, and R.D. Rosenberg. 1992. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature (Lond.). 359:67-70.
26. Morishita, R., G.H. Gibbons, K.E. Ellison, M. Nakajima, L. Zhang, Y. Kaneda, T. Ogihara, and V.J. Dzau. 1993. Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc. Natl. Acad. Sci. USA. 90: 8474-8478.
27. Bennett, M.R., S. Anglin, J.R. McEwan, R. Jagoe, A.C. Newby, and G.I. Evan. 1994. Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by C-myc antisense oligodeoxynucleotides. J. Clin. Invest. 93:820-828.
28. Morishita, R., G.H. Gibbons, K.E. Ellison, M. Nakajima, H. von der Leyen, L. Zhang, Y. Kaneda, T. Ogihara, and V.J. Dzau. 1994. Intimai hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J. Clin. Invest. 93:1458-1464.
29. Simons, M., E.R. Edelman, and R.D. Rosenberg. 1994. Antisense proliferating cell nuclear antigen oligonucleotides inhibit intimai hyperplasia in a rat carotid artery injury model. J. Clin. Invest. 93:2351-2356.
30. Shi, Y., A. Fard, A. Galeo, H.G. Hutchinson, P. Vermani, G.R. Dodge, D.J. Hall, F. Shaheen, and A. Zalewski. 1994. Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury. Circulation. 90:944-951.
31. Villa, A.E., L.A. Guzman, E.J. Poptic, V. Labhasetwar, S. D'Souza, C.L. Farrell, E.F. Plow, R.J. Levy, P.E. DiCorleto, and E.J. Topol. 1995. Effects of antisense c-myb oligonucleotides on vascular smooth muscle cell proliferation and response to vessel wall injury. Circ. Res. 76:505-513.
32. Bi, W.L., L.M. Parysek, R.J. Warnick, and P.J. Stambrook. 1993. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV-tk retroviral gene therapy. Hum. Gene Ther. 4:725-731.
33. Freeman, S.M., C.N. Abboud, K.A. Whartenby, C.H. Packman, D.S. Koeplin, F.L. Moolten, and G.N. Abraham. 1993. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 53:5274-5283.
34. Lemarchand, P., M. Jones, I. Yamada, and R.G. Crystal. 1993. In vivo gene transfer and expression in normal uninjured blood vessels using replication-defective recombinant adenovirus vectors. Circ. Res. 72:1132-1138.
35. Guzman, R.J., P. Lemarchand, R.G. Crystal, S.E. Epstein, and T. Finkel. 1993. Efficient and selective adenovirus-mediated gene transfer into vascular neointima. Circulation. 88:2838-2848.
36. Barr, E., J. Carroll, A.M. Kalynych, S.K. Tripathy, K. Kozarsky, J.M. Wilson, and J.M. Leiden. 1994. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Gene Ther. 1:51-58.
37. Steg, P.G., L.J. Feldman, J.-Y. Scoazec, O. Tahlil, J.J. Barry, S. Boulechfar, T. Ragot, J.M. Isner, and M. Perricaudet. 1994. Arterial gene transfer to rabbit endothelial and smooth muscle cells using percutaneous delivery of an adenoviral vector. Circulation. 90:1648-1656.
38. Rosenfeld, M.E., and R. Ross. 1990. Macrophage and smooth muscle cell proliferation in atherosclerotic lesions of WHHL and comparable hypercholesterolemic fat-fed rabbits. Arteriosclerosis. 10:680-687.
39. Stadius, M.L., A.M. Gown, R. Kernoff, and C.L. Collins. 1994. Cell proliferation after balloon injury of iliac arteries in the cholesterol-fed New Zealand White rabbit. Arterioscler. Thromb. 14:727-733.
40. Kakuta, T., J.W. Currier, C.C. Haudenschild, T.J. Ryan, and D. Faxon. 1994. Differences in compensatory vessel enlargement, not intimal formation, account for restenosis after angioplasly in the hypercholeslerolemic rabbit model. Circulation. 89:2809-2815.
41. Cohen, A.J., B. Weiser, Q. Afzal, and J. Fuhrer. 1990. Ventricular tachycardia in two patients with AIDS receiving ganciclovir. AIDS (Phila.). 4:807-809.
42. Faulds, D., and R.C. Heel. 1990. Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections. Drugs. 39:597-638.
43. Culver, K.W., and J. VanGilder. 1994. Clinical protocol: gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system. Hum. Gene Ther. 5:343-379.