Structural basis of molecular mimicry

Journal of Autoimmunity

Volumn 16, Issue 3, 2001, Pages 293-302

  Wucherpfennig, Kai W ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; AUTOIMMUNE DISEASE; CONFERENCE PAPER; CROSS REACTION; GENETIC PROCEDURES; MOLECULAR MIMICRY; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0034988649     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.2000.0499     Document Type: Conference Paper

References (58)

1. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: Mechanism for autoimmunity
2. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
3. T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination
4. The T lymphocyte in experimental allergic encephalomyelitis
5. Islet-specific T cell clones transfer diabetes to nonobese diabetic (NOD) F1 mice
6. Migration of hematogenous cells through the blood-brain barrier and the initiation of CNS inflammation
7. Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen
8. Treatment of PL/J mice with the superantigen, staphylococcal enterotoxin B, prevents development of experimental allergic encephalomyelitis
9. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
10. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
11. A full genome search in multiple sclerosis
12. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex
13. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity
14. Activation of autoreactive T cells by peptides from human pathogens
15. Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
16. The genetics of susceptibility to multiple sclerosis
17. Genetics of demyelinating diseases
18. MHC class-II molecules and autoimmunity
19. Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: A mechanism for MHC-linked susceptibility to human autoimmune diseases
20. Epidemiologic contributions to multiple sclerosis: An overview
21. Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals
22. T-cell recognition of an immunodominant myelin basci protein epitope in multiple sclerosis
23. Myelin autoreactivity in multiple sclerosis: Recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors
24. Clonal expression and persistence of human T cells specific for an immunodominant myelin basic protein peptide
25. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones
26. Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides
27. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles
28. Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry
29. Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: Positioning of T-cell receptors on HLA-DR2/peptide complexes
30. Induction of Epstein-Barr virus-associated DNA polymerase by 12-O-tetradecanoylophorbol-13-acetate. Purification and characterization
31. Structural features of autoreactive TCR that determine the degree of degeneracy in peptide recognition
32. Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. Implications for thymic education and autoimmunity
33. Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous ligands
34. Intramolecular mimicry. Identification and analysis of two cross-reactive T cell epitopes within a single protein
35. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone
36. Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones
37. Recognition of multiple peptide cores by a single T cell receptor
38. In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis
39. Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein
40. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
41. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
42. Crystallographic anlaysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides
43. Effect of natural polymorphism at residue 86 of the HLA-DRβ chain on peptide binding
44. HLA class II region nucleotide sequences
45. Peptide binding specificity of HLA-DR4 molecules: Correlation with rheumatoid arthritis association
46. X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II
47. HLA class II allelic variation and susceptibility to pemphigus vulgaris
48. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
49. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids
50. Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical
51. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex
52. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen
53. The crystal structure of a T cell receptor in complex with peptide and MHC class II
54. Structure of a covalently stabilized complex of a human αβ T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1
55. Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures
56. Structural evidence for induced fit as a mechanism for antibody-antigen recognition
57. Occurrence of MRI abnormalities in patients with isolated optic neuritis
58. Campylobacter jejuni infection and Guillain-Barré syndrome