Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 2, 1996, Pages 734-738

  Jardetzky, Theodore S ^a,e   Brown, Jerry H ^a,b   Gorga, Joan C ^c   Stern, Lawrence J ^a,d   Urban, Robert G ^a   Strominger, Jack L ^a   Wiley, Don C ^a  

^a HARVARD UNIVERSITY   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

immunology; major histocompatibility complex; peptide binding

Indexed keywords

HLA DR1 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ARTICLE; CONTROLLED STUDY; CRYSTALLOGRAPHY; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY; HLA-DR1 ANTIGEN; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 0030069683     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.2.734     Document Type: Article

References (29)

1. Germain, R. M. & Margulies, D. H. (1993) Annu. Rev Immunol. 11, 403-450.
2. Rudensky, A., Preston-Hurlburt, P., Hong, S. C., Barlow. A. & Janeway, C., Jr. (1991) Nature (London) 353, 622-627.
3. Chicz, R. M., Urban, R. G., Laue, W. S., Gorga, J. C., Stern, L. J., Vignali, D. A. A. & Strominger, J. L. (1992) Nature (London) 358, 764-768.
4. Van Bleek, G. M. & Nathenson, S. G. (1990) Nature (London) 348, 213-216.
5. Falk, K., Rotzschke, O., Stevanovic, S., Jung, G. & Rammensee, H. G. (1991) Nature (London) 351, 290-296.
6. Hunt, D. F., Henderson, R. A., Shabanowitz, J., Sakaguchi, K., Michel, H., Sevilir, N., Cox, A. L., Appella, E. & Engelhard, V. H. (1992) Science 255, 1261-1263.
7. Stern, L. J. & Wiley, D. C. (1994) Structure 2, 245-251.
8. Madden, D. R., Gorga, J. C., Strominger, J. L. & Wiley, D. C. (1991) Nature (London) 353, 321-325.
9. Madden, D. R., Garboczi, D. N. & Wiley, D. C. (1993) Cell 75, 693-708.
10. Brown, J. H., Jardetzky, T. S., Gorga, J. C., Stern, L. J., Urban, R. G., Strominger, J. L. & Wiley, D. C. (1993) Nature (London) 364, 33-39.
11. Stern, L. J., Brown, J. H., Jardetzky, T. S., Gorga, J. C., Urban, R. G., Strominger, J. L. & Wiley, D. C. (1994) Nature (London) 368, 215-221.
12. Bouvier, M. & Wiley, D. C. (1994) Science 265, 398-402.
13. Madden, D. R., Gorga, J. C., Strominger, J. L. & Wiley, D. C. (1992) Cell 70, 1035-1048.
14. Guo, H. C., Jardetzky, T. S., Garrett, T. P. J., Lane, W. S., Strominger, J. L. & Wiley, D. C. (1992) Nature (London) 360, 364-366.
15. Ghosh, P., Amaya, E., Mellins, E. & Wiley, D. C. (1995) Nature (London) 378, 457-462.
16. Jardetzky, T. S., Brown, J. H., Gorga, J. C., Stern, L. J., Urban, R. G., Chi, Y.-I., Stauffacher, C., Strominger, J. L. & Wiley, D. C. (1994) Nature (London) 368, 711-718.
17. Brünger, A. T. (1993) XPLOR Manual (Yale Univ. Press, New Haven, CT), Version 3.0.
18. Hoffmann, M. L., Jablonski, L. M., Crum, K. K., Hackett, S. O., Chi, Y.-I., Stauffacher, C. V., Stevens, D. L. & Bohach, G. A. (1994) Infect. Immun. 62, 3396-3407.
19. Navaza, J. (1994) Acta Crystallogr. A50, 157-163.
20. Hammer, J., Takacs, B. & Sinigaglia, F. (1992) J. Exp. Med. 176, 1007-1013.
21. Hammer, J., Valsasnini, P., Tolba, K., Bolin, D., Higelin, J., Takacs, B. & Sinigaglia, F. (1993) Cell 74, 197-203.
22. Sette, A., Sidney, J., Oseroff, C., del Guercio, M. F., Southwood, S., Arrhenius, T., Powell, M. F., Colon, S. M., Gaeta, F. C. A. & Grey, H. M. (1993) J. Immunol. 151, 3163-3170.
23. Jardetzky, T. S., Gorga, J. C., Busch, R., Rothbard, J., Strominger, J. L. & Wiley, D. C. (1990) EMBO J. 9, 1797-1803.
24. Feng, S., Chen, J. K., Yu, H., Simon, J. A. & Schreiber, S. L. (1994) Science 266, 1241-1247.
25. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 945-949.
26. Adzhubei, A. A. & Sternberg, M. J. E. (1993) J. Mol. Biol. 229, 472-493.
27. Le Questel, J. Y., Morris, D. G., Maccallum, P. H., Poet, R. & Milner-White, E. J. (1993) J. Mol. Biol. 231, 888-896.
28. Honig, B. & Nicholls, A. (1995) Science 268, 1144-1149.
29. Thibodeau, J., Cloutier, I., Labreque, N., Mourad, W., Jardetzky, T. & Sékaly, R.-P. (1994) Science 266, 1874-1878.