Axonal injury or loss in the internal capsule and motor impairment in multiple sclerosis

Archives of Neurology

Volumn 57, Issue 1, 2000, Pages 65-70

  Lee, Martin A ^a   Blamire, Andrew M ^b   Pendlebury, Sarah ^a   Ho, King Hee ^a   Mills, Kerry R ^a   Styles, Peter ^b   Palace, Jackie ^a   Matthews, Paul M ^a,b  

^a RADCLIFFE INFIRMARY   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

N ACETYLASPARTIC ACID;

ADULT; ARTICLE; CAPSULA INTERNA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MOTOR DYSFUNCTION; MOTOR NERVE CONDUCTION; MOTOR PERFORMANCE; MULTIPLE SCLEROSIS; NERVE INJURY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; WHITE MATTER;

EID: 0033970430     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.57.1.65     Document Type: Article

References (42)

1. Rivera-Quinones C, McGavern D, Schmelzer JD, et al. Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis. Nat Med. 1998;4:187-193.
2. Youl BD, Turano G, Miller DH, et al. The pathophysiology of acute optic neuritis: an association of gadolinium leakage with clinical and electrophysiological deficits. Brain. 1991;14:2437-2450.
3. Foster RE, Whalen CC, Waxman SG. Reorganization of the axon membrane in demyelinated peripheral nerve fibers: morphological evidence. Science. 1980; 210:661-663.
4. England JD, Gamboni F, Levinson SR, et al. Changed distribution of sodium channels along demyelinated axons. Proc Natl Acad Sci U S A. 1990;87:6777-6780.
5. Matthews PM, De Stefano N, Narayanan S, et al. Putting magnetic resonance spectroscopy studies in context: axonal damage and disability in multiple sclerosis. Semin Neurol. 1998;18:327-336.
6. Ferguson B, Matyszak MK, Esiri MM, et al. Axonal damage in acute multiple sclerosis lesions. Brain. 1997;120:393-399.
7. Trapp BD, Peterson J, Ransohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med. 1998;338:278-285.
8. Barnes D, Munro PM, Youl BD, et al. The longstanding MS lesion: a quantitative MRI and electron microscopic study. Brain. 1991;114:1271-1280.
9. Raine CS. The neuropathology of multiple sclerosis. In: Raine CS, McFarland HF, eds. Multiple Sclerosis: Clinical and Patholgenic Basis. Vol. 9. London, England: Chapman & Hall; 1997:151-171.
10. Matthews PM, Francis G, Antel J, et al. Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiple sclerosis [published correction appears in Neurology. 1991;41:1828]. Neurology. 1991;41:1251-1256.
11. Larsson HB, Christiansen P, Jensen M, et al. Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis. Magn Reson Med. 1991; 22:23-31.
12. Davie CA, Hawkins CP, Barker GJ, et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain. 1994;117:49-58.
13. De Stefano N, Matthews PM, Antel JP, et al. Chemical pathology of acute demyelinating lesions and its correlation with disability. Ann Neurol. 1995;38:901-909.
14. Husted CA, Goodin DS, Hugg JW, et al. Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo 31P and 1H spectroscopic imaging. Ann Neurol, 1994;6:157-165.
15. Fu L, Wolfson C, Worsley KJ, et al. Statistics for investigation ot multimodal MR imaging data and an application to multiple sclerosis patients. NMR Biomed. 1996; 9:339-346.
16. Losseff NA, Wang L, Lai HM, et al. Progressive cerebral atrophy in multiple sclerosis: a serial MRI study. Brain. 1996;119:2009-2019.
17. Losseff NA, Webb SL, O'Riordan JI, et al. Spinal cord atrophy and disability in multiple sclerosis: a new reproducible and sensitive MRI method with potential to monitor disease progression. Brain. 1996;119:701-706.
18. Truyen L, van-Waesberghe JH, van-Walderveen MA, et al. Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis. Neurology. 1996;47:1469-1476.
19. Fu L, Matthews PM, De Stefano N, et al. Imaging axonal damage of normal-appearing white matter in multiple sclerosis. Brain. 1998;121:103-113.
20. Davie CA, Barker GJ, Webb S, et al. Persistent functional deficit in multiple sclerosis and autosomal-dominant cerebellar ataxia is associated with axon loss. Brain. 1995;118:1583-1592.
21. Demeurisse G, Demol O, Robaye E. Motor evaluation in vascular hemiplagia. Eur Neurol. 1980;19:382-389.
22. Sunderland A, Deborah T, Bradley L. et al. Arm function after stroke: an evaluation of grip strength as a measure of recovery and a prognostic indicator. J Neurol. 1989;52:1267-1272.
23. Sharpless JW. The nine hole peg test of finger hand coordination for the hemiplegic patient. In: Sharpless JW, ed. Mossman's A Problem Orientated Approach to Stroke Rehabilitation. Springfield, III: Charles C Thomas Publisher; 1982:420-423.
24. Salmaso D, Longoni AM. Problems in the assessment of hand preference. Cortex. 1985;21:533-549.
25. Davidoff RA. The pyramidal tract. Neurology. 1990;40:332-339.
26. Bottomley PA. Spatial localization in NMR spectroscopy in vivo. Ann N Y Acad Sci. 1987;508:333-348.
27. Haase A, Frahm J, Hanicke W, et al. 1H NMR chemical shift selective (CHESS) imaging. Phys Med Biol. 1985;30:341-344.
28. Mills KR, Nithi KA. Corticomotor threshold to magnetic stimulation: normal values and repeatability. Muscle Nerve. 1997;20:570-576.
29. Mills KR, Murray NM. Corticospinal tract conduction time in multiple sclerosis. Ann Neurol. 1985;18:601-605.
30. Berardelli A, Inghilleri M, Formisano R, et al. Stimulation of motor tracts in motor neuron disease. J Neurol Neurosurg Psychiatry. 1987;50:732-737.
31. Mills KR, Nithi KA. Corticomotor threshold is reduced in early idiopathic amyotrophic lateral sclerosis. Muscle Nerve. 1997;20:1137-1141.
32. Berardelli A, Inghilleri M, Cruccu G, et al. Electrical and magnetic transcranial stimulation in patients with corticospinal damage due to stroke or motor neuron disease. Electroencephalogr Clin Neurophysiol. 1991;81:389-396.
33. Lacomis D, Osbakken M, Gross G. Spin-lattice relaxation (T1) times of cerebral white matter in multiple sclerosis. Magn Reson Med. 1986;3:194-202.
34. Larsson HB, Frederiksen J, Kjaer L, et al. In vivo determination of T1 and T2 in the brain of patients with severe but stable multiple sclerosis. Magn Reson Med. 1988;7:43-55.
35. Miller DH, Johnson G, Tofts PS, et al. Precise relaxation time measurements of normal-appearing white matter in inflammatory central nervous system disease. Magn Reson Med. 1988;11:331-336.
36. Dousset V, Grossman RI, Ramer KN, et al. Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging. Radiology. 1992;182:483-491.
37. Larsson HB, Thomsen C, Frederiksen J, et al. In vivo magnetic resonance diffusion measurement in the brain of patients with multiple sclerosis. Magn Reson Imaging. 1992;10:7-12.
38. Raine CS, Cross AH. Axonal dystrophy as a consequence of long-term demyelination. Lab Invest. 1989;60:714-725.
39. Kidd D, Thompson PD, Day BL, et al. Central motor conduction time in progressive multiple sclerosis: correlations with MRI and disease activity. Brain. 1998; 121:1109-1116.
40. Doyle TJ, Bedell BJ, Narayana PA. Relative concentrations of proton MR visible neurochemicals in gray and white matter in human brain. Magn Reson Med. 1995; 33:755-759.
41. Frahm J, Pouwels PJ. Regional metabolite concentrations in human brain as determined by quantitative localised proton MRS. Magn Reson Med. 1998;39:53-60.
42. Tedeschi G, Righini A, Bizzi A, et al. Cerebral white matter in the centrum semiovale exhibits a larger N-acetyl signal than does grey matter in long echo time 1H-magnetic resonance spectroscopic imaging. Magn Reson Med. 1995:33:127-133.