Evidence for the chronic in vivo production of human T cell leukemia virus type I Rof and Tof proteins from cytotoxic T lymphocytes directed against viral peptides

Journal of Experimental Medicine

Volumn 191, Issue 3, 2000, Pages 567-572

  Pique, Claudine ^a,b   Ureta Vidal, Abel ^c   Gessain, Antoine ^c   Chancerel, Bruno ^d   Gout, Olivier ^e   Tamouza, Riad ^b   Agis, Frantz ^d   Dokhélar, Marie Christine ^a  

^a INSERM   (France)

^b SAINT LOUIS HOSPITAL   (France)

^c INSTITUT PASTEUR   (France)

^d Etablissement de Transfusion Sanguine   (Guadeloupe)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Cytotoxic epitopes; HLA A2; Interferon ; Regulatory proteins; Retrovirus

Indexed keywords

CD8 ANTIGEN; EPITOPE; GAMMA INTERFERON; HLA A2 ANTIGEN; REGULATOR PROTEIN; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNE RESPONSE; OPEN READING FRAME; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; T LYMPHOCYTE SUBPOPULATION;

AMINO ACID SEQUENCE; CARRIER STATE; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; GENES, PX; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; INTERFERON TYPE II; MOLECULAR SEQUENCE DATA; RETROVIRIDAE PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0034614907     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.3.567     Document Type: Article

References (20)

1. HTLV-1 oncoprotein tax and cellular transcription factors
2. Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I
3. X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro
4. Selective ablation of human T-cell lymphotropic virus type 1 p12(I) reduces viral infectivity in vivo
5. A deletion in the proximal untranslated pX region of human T-cell leukemia virus type II decreases viral replication but not infectivity in vivo
6. Antibody reactivities to tumor-suppressor protein p53 and HTLV-I T of, Rex and Tax in HTLV-I-infected people with differing clinical status
7. Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes
8. HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells
9. Among all human T-cell leukemia virus type 1 proteins, tax, polymerase, and envelope proteins are predicted as preferential targets for the HLA-A2-restricted cytotoxic T-cell response
10. High human T cell lymphotropic vires type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease
11. Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease
12. Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia
13. CD8 T cell memory in B cell-deficient mice
14. A sensitive ELISPOT assay for detection of CD8+ T lymphocytes specific for HLA class I-binding peptide epitopes derived from influenza proteins in the blood of healthy donors and melanoma patients
15. Increased production of interferon gamma but not interleukin 4 in human T-lymphotropic virus type I carriers
16. HTLV-I-induced T-cell activation
17. Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy
18. Activated, HTLV-1-specific cytotoxic T-lymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis
19. Demonstration of human T lymphotropic virus type I (HTLV-I) tax-specific CD8+ lymphocytes directly in peripheral blood of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by intracellular cytokine detection