Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation

Genetics

Volumn 158, Issue 2, 2001, Pages 627-634

  Denis, Clyde L ^a   Chiang, Yueh Chin ^a   Cui, Yajun ^a   Chen, Junji ^a  

^a UNIVERSITY OF NEW HAMPSHIRE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZAURACIL; ELONGATION FACTOR; MESSENGER RNA; MYCOPHENOLIC ACID;

ALLELISM; ARTICLE; GENE DELETION; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; MUTATION; NONHUMAN; PRIORITY JOURNAL; RNA DEGRADATION; TRANSCRIPTION INITIATION; YEAST;

ALLELES; ANTIMETABOLITES; COLD; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE DELETION; MUTATION; MYCOPHENOLIC ACID; PHENOTYPE; RIBONUCLEASES; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE PROTEINS; TEMPERATURE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; URACIL;

EID: 0034971991     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

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2. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits
3. Genetic interaction between transcription elongation factor TFIIS and RNA polymerase II
4. Functional interaction of CCR4-NOT proteins with TATAA-Binding Protein (TBP) and its associated factors in yeast
5. The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5
6. Association of distinct yeast Not2 functional domains with components of Gcn5 histone acetylase and Ccr4 transcriptional regulatory complexes
7. A complex containing RNA polymerase II, Paflp, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling
8. The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability
9. A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae
10. The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters
11. CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters
12. NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization
13. Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation
14. Transcription factor TFIID recruits factor CPSF for formation of 3′ end of mRNA
15. Identification of new genes involved in the regulation of yeast alcohol dehydrogenase II
16. The CCR4 gene from Saccharomyces cerevisiae is required for both nonfermentative and spt-mediated gene expression
17. Functionally unrelated signaling proteins contain a fold similar to Mg2+-dependent endonucleases
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19. Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex
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27. RNA polymerase II is an essential mRNA polyadenylation factor
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32. DBF2 protein kinase binds to and acts through the cell cycle-regulated MOB1 protein
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34. 1119p functionally interacts with components of the global transcriptional regulator CCR4-NOT complex and physically interacts with the Not5 subunit
35. Mutations in RNA polymerase II and elongation factor SII severely reduce mRNA levels in Saccharomyces cerevisiae
36. 11230 complex: Protein mimicry of the minor groove surface of the TATA box unwound by TBP
37. The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively
38. DBF2, a cell cycle-regulated protein kinase is physically and functionally associated with the CCR4 transcriptional regulatory complex
39. Characterization of CAF4 and CAF16 reveal a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme
40. The essential function of Not1 lies within the Ccr4-Not complex
41. 5′-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II
42. 11250 subunit of TFIID has histone acetyl-transferase activity
43. The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains
44. Turnover mechanisms of the stable yeast PGK1 mRNA
45. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins
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47. The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa
48. 11250, a mediator of activation of gene expression in Drosophila
49. Mutations in the second largest subunit of RNA polymerase II cause 6-azauracil sensitivity in yeast and increased transcriptional arrest in vitro
50. Molecular analysis of POP2 gene, a gene required for glucose-derepression of gene expression in Saccharomyces cerevisiae
51. Dynamic association of capping enzymes with transcribing RNA polymerase II
52. Saccharomyces cerevisiae transcription elongation mutants are defective in PUR5 induction in reponse to nucleotide depletion
53. Transcription elongation factor S-II confers yeast resistance to 6-Azauracil by enhancing expression of the SSM1 gene
54. Functional organization of the yeast SAGA complex: Distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction
55. Dissection of transcription factor TFIIF functional domains required for initiation and elongation
56. The transcription factor associated proteins Ccr4 and Cafl proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae
57. Basic mechanisms of transcript elongation and its regulation
58. Yeast exosome mutants accumulate 3′-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs
59. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs