The BvgAS two-component system of bordetella spp.: A versatile modulator of virulence gene expression

International Journal of Medical Microbiology

Volumn 291, Issue 2, 2001, Pages 119-130

  Bock, Andreas ^a   Gross, Roy ^a,b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b R Mikrobiol Biozentrum Universituml T Wuuml Rzburg Am Hubland D 97074 Wuuml Rzburg   (Germany)

Author keywords

Bordetella; BvgA; BvgS; Phosphorelay; Two component systems; Whooping cough

Indexed keywords

BORDETELLA; BORDETELLA BRONCHISEPTICA; BORDETELLA PARAPERTUSSIS; BORDETELLA PERTUSSIS;

EID: 0034965462     PISSN: 14384221     EISSN: None     Source Type: Journal    
DOI: 10.1078/1438-4221-00109     Document Type: Article

References (119)

1. Ectopic expression of the flagellar regulon alters development of the Bordetella-host interaction
2. Flagellin gene transcription in Bordetella bronchiseptica is regulated by the BvgAS virulence control system
3. Reductive evolution of resident genomes
4. New virulence-activated and virulence-repressed genes identified by systematic gene inactivation and generation of transcriptional fusions in Bordetella pertussis
5. Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins
6. Adhesion of Bordetella pertussis to eukaryotic cells requires a time-dependent export and maturation of filamentous hemagglutinin
7. Tracheal lesions in young turkeys infected with Bordetella avium
8. NarL dimerization? Suggestive evidence from a new crystal form
9. The lipopolysaccharide of Bordetella bronchiseptica acts as a protective shield against antimicrobial peptides
10. Phase variation affects long-term survival of Bordetella bronchiseptica in professional phagocytes
11. Repressor binding to a regulatory site in the DNA coding sequence is sufficient to confer transcriptional regulation of the vir-repressed genes (vrg genes) in Bordetella pertussis
12. Conserved sequence motifs in the unorthodox BvgS two-component sensor protein of Bordetella pertussis
13. In vivo characterization of the unorthodox BvgS two-component sensor protein of Bordetella pertussis
14. The modular architecture of bacterial response regulators. Insights into the activation mechanism of the BvgA transactivator of Bordetella pertussis
15. Nature of DNA binding and RNA polymerase interaction of the Bordetella pertussis BvgA transcriptional activator at the fha promoter
16. Genetic and biochemical analyses of BvgA interaction with the secondary binding region of the fha promoter of Bordetella pertussis
17. Energy-coupled transport and signal transduction through the gram-negative outer membrane via TonB-ExbB-ExbD-dependent receptor proteins
18. Effect of mutations causing overexpression of RNA polymerase alpha subunit on regulation of virulence factors in Bordetella pertussis
19. A phase variant of Bordetella pertussis with a mutation in a new locus involved in the regulation of pertussis toxin and adenylate cyclase toxin expression
20. Overexpression of the RNA polymerase alpha subunit reduces transcription of Bvg-activated virulence genes in Bordetella pertussis
21. Bacteremia caused by a novel Bordetella species, "B. hinzii"
22. Bacterial virulence gene regulation: An evolutionary perspective
23. A mutation in the Bordetella bronchiseptica bvgS gene results in reduced virulence and increased resistance to starvation, and identifies a new class of Bvg-regulated antigens
24. BvgAS-mediated signal transduction: Analysis of phase-locked regulatory mutants of Bordetella bronchiseptica in a rabbit model
25. Filamentous hemagglutinin of Bordetella bronchiseptica is required for efficient establishment of tracheal colonization
26. Identification of a Bordetella pertussis regulatory factor required for transcription of the pertussis toxin operon in Escherichia coil
27. Nonrestricted differential intoxication of cells by pertussis toxin
28. Effects of exogenous agents on the action of Bordetella parapertussis heat-labile toxin on guinea pig skin
29. Phase-shift markers in the genus Bordetella: Loss of cytochrome d-629 in phase IV variants
30. Serum resistance in bvg-regulated mutants of Bordetella pertussis
31. Vag8, a Bordetella pertussis bvg-regulated protein
32. Identification of a Bordetella pertussis bvg-regulated porin-like protein
33. Tracheal colonization factor: A Bordetella pertussis secreted virulence determinant
34. Synergistic epithelial responses to endotoxin and a naturally occurring muramyl peptide
35. A new gene locus of Bordetella pertussis defines a novel family of prokaryotic transcriptional accessory proteins
36. Evolutionary trends in the genus Bordetella
37. Role of the Bordetella pertussis minor fimbrial subunit, FimD, in colonization of the mouse respiratory tract
38. bvg repression of alcaligin synthesis in Bordetella bronchiseptica is associated with phylogenetic lineage
39. Biology of Bordetella bronchiseptica
40. Global regulatory mechanisms affect virulence gene expression in Bordetella pertussis
41. Families of bacterial signal-transducing proteins
42. Pertussis toxin promoter sequences involved in modulation
43. Positive regulation of pertussis toxin expression
44. Role of adenylate cyclase-hemolysin in alveolar macrophage apoptosis during Bordetella pertussis infection in vivo
45. Human Bordetella bronchiseptica infection related to contact with infected animals: Persistence of bacteria in host
46. Sulfated glycoconjugate receptors for the Bordetella pertussis adhesin filamentous hemagglutinin (FHA) and mapping of the heparin-binding domain on FHA
47. Epithelial autotoxicity of nitric oxide: Role in the respiratory cytopathology of pertussis
48. Acute respiratory disease in turkey poults caused by Bordetella bronchiseptica-like bacteria
49. Bordetella bronchiseptica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho
50. Decrease in anti-microbial susceptibility of Bordetella bronchiseptica caused by antigenic modulation and phase variation
51. Characterization of DNA binding sites for the BvgA protein of Bordetella pertussis
52. Bordetella pertussis induces apoptosis in macrophages: Role of adenylate cyclase-hemolysin
53. DNA-DNA hybridisation, plasmids, and genetic exchange in the genus Bordetella
54. Two trans-acting regulatory genes (vir and mod) control antigenic modulation in Bordetella pertussis
55. Antigenic modulation of Bordetella pertussis
56. Bordetella pertussis adenylate cyclase: A toxin with multiple talents
57. Antigenic polymorphism of the lipopolysaccharides from human and animal isolates of Bordetella bronchiseptica
58. Pertactin, an Arg-Gly-Asp-containing Bordetella pertussis surface protein that promotes adherence of mammalian cells
59. The phases of Haemophilus pertussis
60. Two-component signal transduction systems in eukaryotic microorganisms
61. Tracheal cytotoxin structural requirements for respiratory epithelial damage in pertussis
62. Filamentous hemagglutinin of Bordetella pertussis. A bacterial adhesin formed as a 50-nm monomeric rigid rod based on a 19-residue repeat motif rich in beta strands and turns
63. Mutations in the linker region of BvgS abolish response to environmental signals for the regulation of the virulence factors in Bordetella pertussis
64. Genetic analysis of pertussis toxin promoter activation in Bordetella pertussis
65. Neither the Bvg phase nor the vrg6 locus of Bordetella pertussis is required for respiratory infection in mice
66. Comparative analysis of the virulence control systems of Bordetella pertussis and Bordetella bronchiseptica
67. Role of Bordetella bronchiseptica fimbriae in tracheal colonization and development of a humoral immune response
68. Expression of urease does not affect the ability of Bordetella bronchiseptica to colonise and persist in the murine respiratory tract
69. Identification of a locus required for the regulation of bvg-repressed genes in Bordetella pertussis
70. Characterization of the bvgR locus of Bordetella pertussis
71. The regulation of gene expression in Bordetella pertussis by quorum sensing
72. Representational difference analysis identifies a strain-specific LPS biosynthesis locus in Bordetella spp.
73. Constitutive sensory transduction mutations in the Bordetella pertussis bvgS gene
74. Phase variants of Bordetella bronchiseptica arise by spontaneous deletions in the vir locus
75. Cloning of Bordetella bronchiseptica urease genes and analysis of colonization by a urease-negative mutant strain in a guinea-pig model
76. Nucleotide sequences of the 23S rRNA genes from Bordetella pertussis, B. parapertussis, B. bronchiseptica and B. avium, and their implications for phylogenetic analysis
77. Response regulators of bacterial signal transduction systems: Selective domain shuffling during evolution
78. Communication modules in bacterial signaling proteins
79. Specificity of the BvgAS and EvgAS phosphorelay is mediated by the C-terminal HPt domains of the sensor proteins
80. Dimerization of signalling modules of the EvgAS and BvgAS phosphorelay systems
81. Signalling pathways in two-component phosphorelay systems
82. Subunit S1 of pertussis toxin: Mapping of the regions essential for ADP-ribosyltransferase activity
83. Long-term survival of Bordetella bronchiseptica in lake water and in buffered saline without added nutrients
84. Acellular pertussis vaccines: A turning point in infant and adolescent vaccination
85. Recognition of a bacterial adhesion by an integrin: Macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis
86. Identification of Bordetella pertussis regulatory sequences required for transcriptional activation of the fhaB gene and autoregulation of the bvgAS operon
87. The bvgA gene of Bordetella pertussis encodes a transcriptional activator required for coordinate regulation of several virulence genes
88. Bordetella pertussis infection in mice: Correlation of specific antibodies against two antigens, pertussis toxin, and filamentous hemagglutinin with mouse protectivity in an intracerebral or aerosol challenge system
89. Sequential activation and environmental regulation of virulence genes in Bordetella pertussis
90. DNA topology affects transcriptional regulation of the pertussis toxin gene of Bordetella pertussis in Escherichia coli and in vitro
91. Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis
92. Identification of the C-terminal part of Bordetella dermonecrotic toxin as a transglutaminase for Rho GTPases
93. Phagosome acidification has opposite effects on intracellular survival of Bordetella pertussis and B. bronchiseptica
94. Characterization of the protective capacity and immunogenicity of the 69-kD outer membrane protein of Bordetella pertussis
95. Molecular characterization of two Bordetella bronchiseptica strains isolated from children with cough
96. Phosphorylated BvgA is sufficient for transcriptional activation of virulence-regulated genes in Bordetella pertussis
97. Identification of two bvg-repressed surface proteins of Bordetella pertussis
98. Subcellular localization and immunological detection of proteins encoded by the vir locus of Bordetella pertussis
99. Mutations affecting the alpha subunit of Bordetella pertussis RNA polymerase suppress growth inhibition conferred by short C-terminal deletions of the response regulator BvgA
100. Identification and characterization of BipA, a Bordetella Bvg-intermediate phase protein
101. PAS domains: Internal sensors of oxygen, redox potential, and light
102. Autophosphorylation and phospho-transfer in the Bordetella pertussis BvgAS signal transduction cascade
103. Central role of the BvgS receiver as a phosphorylated intermediate in a complex two-component phosphorelay
104. Integration of multiple domains in a two-component sensor protein: The Bordetella pertussis BvgAS phosphorelay
105. Bordetella trematum sp. nov., isolated from wounds and ear infections in humans, and reassessment of Alcaligenes denitrificans Ruger and Tan 1983
106. Bordetella hinzii sp. nov., isolated from poultry and humans
107. Molecular evolution and host adaptation of Bordetella spp.: Phylogenetic analysis using multilocus enzyme electro-phoresis and typing with three insertion sequences
108. Phylogenetic relationships and virulence evolution in the genus Bordetella
109. Bordetella petrii sp. nov., isolated from an anaerobic bioreactor and emended description of the genus Bordetella
110. Bordetella pertussis virulence factors affect phagocytosis by human neutrophils
111. Genetic analysis of phase change in Bordetella pertussis
112. Mucosal immune defenses and the response of Bordetella pertussis
113. Bordetella holmesii sp. nov., a new gram-negative species associated with septicemia
114. The bvg accessory factor (Baf) enhances pertussis toxin expression in Escherichia coli and is essential for Bordetella pertussis viability
115. Human infections associated with Bordetella bronchiseptica
116. Modulation of host immune responses, induction of apoptosis and inhibition of NF-kappaB activation by the Bordetella type III secretion system
117. The BvgAS virulence control system regulates type III secretion in Bordetella broncbiseptica
118. Human but not ovine isolates of Bordetella parapertussis are highly clonal as determined by PCR-based RAPD fingerprinting
119. Differential binding of BvgA to two classes of virulence genes of Bordetella pertussis directs promoter selectivity by RNA polymerase