Differential binding of BvgA to two classes of virulence genes of Bordetella pertussis directs promoter selectivity by RNA polymerase

Molecular Microbiology

Volumn 21, Issue 3, 1996, Pages 557-565

  Zu, Tao ^a,b   Manetti, Riccardo ^a   Rappuoli, Rino ^a   Scarlato, Vincenzo ^a  

^a CHIRON VACCINES   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RNA POLYMERASE;

ARTICLE; BACTERIAL VIRULENCE; BORDETELLA PERTUSSIS; GENE CONTROL; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); BORDETELLA PERTUSSIS; ESCHERICHIA COLI;

EID: 0029787492     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.1996.tb02564.x     Document Type: Article

References (36)

1. Aricò, B., Miller, J.F., Roy, C., Stibitz, S., Monack, D.M., Falkow, S., Gross, R., and Rappuoli, R. (1989) Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins. Proc Natl Acad Sci USA 86: 6671-6675.
2. Beier, D., Schwarz, B., Fuchs, T.M., and Gross, R. (1995) In vivo characterization of the unorthodox BvgS two-component sensor protein of Bordetella pertussis. J Mol Biol 248: 596-610.
3. Boucher, P.E., and Stibitz, S. (1995) Synergistic binding of RNA polymerase and BvgA phosphate to the pertussis toxin promoter of Bordetella pertussis. J Bacteriol 177: 6486-6491.
4. Boucher, P.E., Menozzi, F.D., and Locht, C. (1994) The modular architecture of bacterial response regulators. J Mol Biol 241: 363-377.
5. Busby, S., and Ebright, R.H. (1994) Promoter structure, promoter recognition, and transcription activation in prokaryotes. Cell 79: 743-746.
6. Carbonetti, N.H., Fuchs, T.M., Patamawenu, A.A., Irish, T.J., Deppisch, H, and Gross, R. (1994) Effect of mutations causing overexpression of RNA polymerase α subunit on regulation of virulence factors in Bordetella pertussis. J Bacteriol 176: 7267-7273.
7. Coote, J.G. (1991) Antigenic switching and pathogenicity: environmental effects on virulence gene expression in Bordetella pertussis. J Gen Microbiol 137: 2493-2503.
8. Domenighini, M., Relman, D., Capiau, C., Falkow, S., Prugnola, A., Scarlato, V., and Rappuoli, R. (1990) Genetic characterization of Bordetella pertussis filamentous haemagglutinin: a protein processed from an unusually large precursor. Mol Microbiol 4: 787-800.
9. Goyard, S., and Ullmann, A. (1991) Analysis of Bordetella pertussis cya operon regulation by use of cya-lac fusions. FEMS Microbiol Lett 77: 251-256.
10. Gross, R., and Rappuoli, R. (1988) Positive regulation of pertussis toxin expression. Proc Natl Acad Sci USA 85: 3913-3917.
11. Gross, R., and Rappuoli, R. (1989) Pertussis toxin promoter sequences involved in modulation. J Bacteriol 171: 4026-4030.
12. Karimova, G., Bellalou, J., and Ullmann, A. (1996) Phosphorylation-dependent binding of BvgA to the upstream region of the cyaA gene of Bordetella pertussis. Mol Microbiol 20: 489-496.
13. Laoide, B.M., and Ullmann, A. (1990) Virulence dependent and independent regulation of the Bordetella pertussis cya operon. EMBO J 9: 999-1005.
14. McCleary, W.R., and Stock, J.F. (1994) Acetyl phosphate and the activation of two-component response regulators. J Biol Chem 269: 31567-31572.
15. Maxam, A.M., and Gilbert, W. (1977) A new method for sequencing DNA. Proc Natl Acad Sci USA 74: 560-564.
16. Miller, J.F., Mekalanos, J.J., and Falkow, S. (1989a) Coordinate regulation and sensory transduction in the control of bacterial virulence. Science 243: 916-922.
17. Miller, J.F., Roy, C.R., and Falkow, S. (1989b) Analysis of Bordetella pertussis virulence gene regulation by use of transcriptional fusions in Escherichia coli. J Bacteriol 171: 6345-6348.
18. Porter, S.C., North, A.K., Wedel, A.B., and Kustu, S. (1993) Oligomerization of NtrC at the glnA enhancer is required for transcriptional activation. Genes Dev 7: 2258-2273.
19. Prugnola, A., Aricò, B., Manetti, R., Rappuoli, R., and Scarlato, V. (1995) Response of the bvg regulon of Bordetella pertussis to different temperatures and short term temperature shifts. Microbiol 141: 2529-2534.
20. Ross, W., Gosink, K.K., Salomon, J., Igarashi, K., Zou, C., Ishihama, A., Severinov, K., and Gourse, R.L. (1993) A third recognition element in bacterial promoters: DNA binding by the α subunit of RNA polymerase. Science 262: 1407-1413.
21. Roy, C.R., and Falkow, S. (1991) Identification of Bordetella pertussis regulatory sequences required for transcriptional activation of the fhaB gene and autoregulation of the bvgAS operon. J Bacteriol 173: 2385-2392.
22. Roy, C.R., Miller, J.F., and Falkow, S. (1989) The bvgA gene of Bordetella pertussis encodes a transcriptional activator required for coordinate regulation of several virulence genes. J Bacteriol 171: 6338-6344.
23. Roy, C.R., Miller, J.F., and Falkow, S. (1990) Autogenous regulation of the Bordetella pertussis bvgABC operon. Proc Natl Acad Sci USA 87: 3763-3767.
24. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. 2nd edn. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
25. Scarlato, V., Prugnola, A., Aricò, B., and Rappuoli, R. (1990) Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis. Proc Natl Acad Sci USA 87: 6753-6757.
26. Scarlato, V., Aricò, B., Prugnola, A., and Rappuoli, R. (1991a) Sequential activation and environmental regulation of the virulence genes in Bordetella pertussis. EMBO J 10: 3971-3975.
27. Scarlato, V., Prugnola, A., Aricò, B., and Rappuoli, R. (1991b) The bvg-dependent promoters show similar behaviour in different Bordetella species and share sequence homologies. Mol Microbiol 5: 2493-2498.
28. Scarlato, V., Aricò, B., and Rappuoli, R. (1993) DNA topology affects transcriptional regulation of the pertussis toxin gene of Bordetella pertussis in Escherichia coli and in vitro. J Bacteriol 175: 4764-4771.
29. Steffen, P., Goyard, S., and Ullmann, A. (1996) Phosphorylated BvgA is sufficient for transcriptional activation of virulence-regulated genes in Bordetella pertussis. EMBO J 15: 102-109.
30. Stevens, A.M., Dolan, K.M., and Greenberg, E.P. (1994) Synergistic binding of the Vibrio fischeri LuxR transcriptional activator domain and RNA polymerase to the lux promoter region. Proc Natl Acad Sci USA 91: 12619-12623.
31. Stibitz, S. (1994) Mutations in the bvgA gene of Bordetella pertussis that differentially affect regulation of virulence determinants. J Bacteriol 176: 5615-5621.
32. Stibitz, S., and Yang, M.-S. (1991) Subcellular localization and immunological detection of proteins encoded by the vir locus of Bordetella pertussis. J Bacteriol 173: 4288-4296.
33. Stock, J.F., Stock, A.M., and Mottonen, J.M. (1990) Signal transduction in bacteria. Nature 344: 395-400.
34. Tabor, S., and Richardson, C.C. (1985) A bacteriophage T-7 RNA polymerase-promoter system for controlled exclusive expression of specific genes. Proc Natl Acad Sci USA 82: 1074-1078.
35. Uhl, M.A., and Miller, J.F. (1994) Autophosphorylation and phosphotransfer in the Bordetella pertussis BvgAS signal transduction cascade. Proc Natl Acad Sci USA 91: 1163-1167.
36. Weiss, A.A., Hewlett, E.L., Myers, G.A., and Falkow, S. (1983) Tn5-induced mutations affecting virulence factors of Bordetella pertussis. Infect Immun 42: 33-41.