Serum resistance in bvg-regulated mutants of Bordetella pertussis

FEMS Microbiology Letters

Volumn 163, Issue 1, 1998, Pages 57-63

  Fernandez, Rachel C ^a   A Weiss, Alison ^a  

^a Dept Molec Genet Biochem M   (United States)

Author keywords

Bordetella pertussis; BrkA; Complement resistance; Mucosal pathogen; Serum resistance; Whooping cough

Indexed keywords

AMPICILLIN; BACTERIAL TOXIN; GENTAMICIN; KANAMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL VIRULENCE; BORDETELLA PERTUSSIS; COMPLEMENT ACTIVATION; NONHUMAN; PRIORITY JOURNAL; TOXIN SYNTHESIS; TRACHEA;

ADENYLATE CYCLASE TOXIN; ADHESINS, BACTERIAL; ADULT; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BLOOD; BLOOD BACTERICIDAL ACTIVITY; BORDETELLA PERTUSSIS; COMPLEMENT PATHWAY, CLASSICAL; HEMAGGLUTININS; HUMANS; MEMBRANE PROTEINS; MUTATION; PERTUSSIS TOXIN; TRANSCRIPTION FACTORS; VIRULENCE; VIRULENCE FACTORS, BORDETELLA; WHOOPING COUGH;

EID: 0032102942     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(98)00127-X     Document Type: Article

References (19)

1. Charles, I.G., Dougan, G., Pickard, D., Chatfield, S., Smith, M., Novotny, P., Morrissey, P. and Fairweather, N.F. (1989) Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis. Proc. Natl. Acad. Sci. USA 86, 3554-3558.
2. Fernandez, R.C. and Weiss, A.A. (1994) Cloning and sequencing of a Bordetella pertussis serum resistance locus. Infect. Immun. 62, 4727-4737.
3. Weiss, A.A. (1997) Mucosal immune defenses and the response of Bordetella pertussis. ASM News 63, 22-28.
4. Weiss, A.A. and Hewlett, E.L. (1986) Virulence factors of Bordetella pertussis. Annu. Rev. Microbiol. 40, 661-686.
5. Finn, T.A. and Stevens, L.A. (1995) Tracheal colonization factor: a Bordetella pertussis secreted virulence determinant. Mol. Microbiol. 16, 625-634.
6. Persson, C.G.A. et al. (1991) Plasma exudation as a first line respiratory mucosal defence. Clin. Exp. Allergy 21, 17-24.
7. Walker, K.E. and Weiss, A.A. (1994) Characterization of the dermonecrotic toxin in the genus Bordetella. Infect. Immun. 62, 3817-3828.
8. Fernandez, R.C. and Weiss, A.A. (1996) Susceptibilities of Bordetella pertussis strains to antimicrobial peptides. Antimicrob. Agents Chemother. 40, 1041-1043.
9. Musser, J.M., Hewlett, E.L., Peppler, M.S. and Selander, R.K. (1986) Genetic diversity and relationships in populations of Bordetella spp. J. Bacteriol. 166, 230-237.
10. Berggard, K., Johnsson, E., Mooi, F.R. and Lindahl, G. (1997) Bordetella pertussis binds the human complement regulator C4BP: Role of filamentous hemagglutinin. Infect. Immun. 65, 3638-3643.
11. Stibitz, S., Weiss, A.A. and Falkow, S. (1988) Genetic analysis of a region of the Bordetella pertussis chromosome encoding filamentous hemagglutinin and the pleiotropic regulatory locus vir. J. Bacteriol. 170, 2904-2913.
12. Weiss, A.A., Melton, A.R., Walker, K.E., Andraos-Selim, C. and Meidl, J.J. (1989) Use of the promoter fusion transposon Tn5 lac to identify mutations in Bordetella pertussis vir-regulated genes. Infect. Immun. 57, 2674-2682.
13. Weyant, R.S. et al. (1995) Bordetella holmesii sp. nov., a new Gram-negative species associated with septicemia. J. Clin. Microbiol. 33, 1-7.
14. Weiss, A.A. and Goodwin, M.S.M. (1989) Lethal infection by Bordetella pertussis mutants in the infant mouse model. Infect. Immun. 57, 3757-3764.
15. Deville, J.G., Cherry, J.D., Christenson, P.D., Pineda, E., Leach, C.T., Kuhls, T.L. and Viker, S. (1995) Frequency of unrecognized Bordetella pertussis infections in adults. Clin. Infect. Dis. 21, 639-642.
16. Schmitt-Grohe, S., Cherry, J.D., Heininger, U., Uberall, M.A., Pineda, E. and Stehr, K. (1995) Pertussis in German adults. Clin. Infect. Dis. 21, 860-862.
17. Weiss, A.A., Hewlett, E.L., Myers, G.A. and Falkow, S. (1983) Tn5-induced mutations affecting virulence factors of Bordetella pertussis. Infect. Immun. 42, 33-41.
18. Antoine, R. and Locht, C. (1990) Roles of the disulfide bond and the carboxyl-terminal region of the S1 subunit in the assembly and the biosynthesis of pertussis toxin. Infect. Immun. 58, 1518-1526.
19. Finn, T., Shahin, R. and Mekalanos, J.J. (1991) Characterization of vir-activated TnphoA gene fusions in Bordetella pertussis. Infect. Immun. 59, 3273-3279.