A new gene locus of Bordetella pertussis defines a novel family of prokaryotic transcriptional accessory proteins

Journal of Bacteriology

Volumn 178, Issue 15, 1996, Pages 4445-4452

  Fuchs, Thilo M ^a   Deppisch, Heike ^a   Scarlato, Vincenzo ^b   Gross, Roy ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Istituto Ricerche Immunobiologiche   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; BACTERIAL MUTATION; BACTERIAL VIRULENCE; DNA SEQUENCE; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENE LOCUS; HAEMOPHILUS INFLUENZAE; NEISSERIA MENINGITIDIS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; REGULATOR GENE; SUPPRESSOR GENE; TRANSCRIPTION REGULATION;

BACTERIA (MICROORGANISMS); BORDETELLA PERTUSSIS; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; NEISSERIA MENINGITIDIS; PROKARYOTA;

EID: 0029744175     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.178.15.4445-4452.1996     Document Type: Article

References (43)

1. Arico, B., J. F. Miller, C. Roy, S. Stibitz, D. Monack, S. Falkow, R. Gross, and R. Rappuoli. 1989. Sequences required for Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins. Proc. Natl. Acad. Sci. USA 86:6671-6675.
2. Bartlett, D. H., E. Chi, and M. E. Wright. Sequence of the ompH gene from the deep-sea hactcrium Plmlobacterium SS9. Gene 131:125-128.
3. Beier, D., B. Schwarz, T. M. Fuchs, and R. Gross. 1995. In vivo characterization of the unorthodox BvgS two-component sensor protein of Bordetella pertussis. J. Mol. Biol. 248:596-610.
4. Bordet, J., and O. Gengou. 1909. L'endotoxine coquclucheuse. Ann. Inst. Pasteur (Paris) 23:415-419.
5. Boucher, P. E., and S. Stibitz. 1995. Synergistic binding of RNA polymerase and BvgA phosphate to the pertussis toxin promoter of Bordetella pertussis, J. Bacteriol. 177:6486-6491.
6. Carbonelti, N. H., T. M. Fuchs, A. A. Patamawenu, T. J. Irish, H. Deppisch, and R. Gross. 1994. Effect of mutations causing overexpression of RNA polymerase α subunit on regulation of virulence factors in Bordetella pertussis. J. Bacteriol. 176:7267-7273.
7. Carbonetti, N. H., N. Khelef, N. Guiso, and R. Gross. 1993. A phase variant of Bordetella pertussis with a mutation in a new locus involved in the regulation of pertussis toxin and adenylate cyclase toxin expression. J. Bacteriol. 175:6679-6688.
8. Cookson, B. T., D. E. Berg, and W. E. Goldman. 1990. Mutagenesis of Bordetetla pertussis with transposon Tn5tac1: conditional expression of virulence-associated genes. J. Bacteriol. 172:1681-1687.
9. DeShazer, D., G. E. Wood, and R. L. Friedman. 1995. Identification of a Bordetella pertussis regulatory factor required for transcription of the pertussis toxin operon in Escherichia coli. J. Bacteriol. 177:3801-3807.
10. Devereux, J., P. Haeberli, and O. Smithies. 1984. A comprehensive set of sequence analysis programs for the Vax. Nucleic Acids Res. 12:387-395.
11. Figge, R. M., T. M. Ramseier, and M. H. Saier. 1994. The mannitol repressor (MtlR) of Escherichia coli. J. Bacteriol. 176:840-847.
12. Fleischmann, R. D., M. D. Adams, O. White, R. A. Clayton, E. F. Kirkness, A. R. Kerlavage, C. J. Bull, J. F. Tomb, B. A. Dougherty, J. M. Merrick, K. McKenney, G. Sulton, W. FithHugh, C. A. Fields, J. D. Gocayne, J. D. Scott, R. Shirley, L. I. Liu, A. Glodek, J. M. Kelley, J. F. Weidman, C. A. Phillips, T. Spriggs, E. Hedblom, M. D. Cotton, T. R". Utterback, M. C. Hanna, D. T. Mguyen, D. M. Saudek, R. C. Brandon, L. D. Fine, J. L. Fritchman, J. I. Fuhrmann, N. S. Geoghagen, C. L. Gnehm, L. A. McDonald, K. V. Small, C. M. Fraser, H. O. Smith, and J. C. Venter. 1995. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269:496-512.
13. Friedman, A. M., S. R. Long, S. E. Brown, W. J. Buikema, and F. M. Ausubel. 1982. Construction of a broad host range cosmid cloning vector and its use in the genetic analysis of Rhizohium mutants. Gene 18:289-296.
14. Frosch, M., U. Edwards, K. Bousset, B. Krausse, and C. Weissgerber. 1991. Evidence for a common molecular origin of the capsule gene loci in gram negative bacteria expressing group II capsular polysaccharides. Mol. Microbiol. 5:1251-1263.
15. Goyard, S., and A. Ullmann. 1993. Functional analysis of the cya promoter of Bordetella pertussis. Mol. Microbiol. 7:693-704.
16. Graeff-Wohlleben, H., H. Deppisch, and R. Gross. 1995. Global regulatory mechanisms affect virulence gene expression in Bordetella pertussis. Mol. Gen. Genet. 247:86-94.
17. Gross, R., and R. Rappuoli. 1988. Positive regulation of pertussis toxin expression. Proc. Natl. Acad. Sci. USA 85:3913-3917.
18. Gross, R., and R. Rappuoli. 1989. Pertussis toxin promoter sequences involved in modulation. J. Bacteriol. 171:4026-4030.
19. Hall, C. V., M. vanCleemput, K. H. Muench, and C. Yanofsky. 1982. The nucleotide sequence of the structural gene for Escherichia coli tryptophanyl-tRNA synthetase. J. Biol. Chem. 257:6132-6136.
20. Kitten, T., and D. K. Willis, 1996. Suppression of a sensor kinase-dependent phenotype in Pseudomonas syringae by ribosomal proteins L35 and L20. J. Bacteriol. 178:1548-1555.
21. Lacey, B. W. 1960. Antigenic modulation of Bordetella pertussis. J. Hyg. 58:57-93.
22. Leininger, E., M. Roberts, J. G. Keninwr, C. I. G. Fairweather, N. Novotny, and M. J. Brennan. 1991. Pertactin, an Arg-Gly-Asp containing Bordetella pertussis surface protein that promotes adherence of mammalian cells. Proc. Natl. Acad. Sci. USA 88:345-349.
23. Leslie, P. H., and A. D. Gardner. 1931. The phases of Haemophilus pertussis. J. Hyg. 31:423-455.
24. Manoil, C. 1990. Analysis of protein localization by use of gene fusions with complementary properties. J. Bacteriol. 172:1035-1042.
25. Monack, D., B. Arico, R. Rappuoli, and S. Falkow. 1989. Phase variants of Bordetella bronchiseptica arise by spontaneous deletions in the vir locus. Mol. Microbiol. 3:1719-1728.
26. Morales, V. M., A. Backman, and M. Bagdasarian. 1991. A series of widehost-range low-copy-number vectors that allow direct screening for recombinants. Gene 97:39-47.
27. Parkinson, J. S., and E. C. Kofoid. 1992. Communication modules in bacterial signaling proteins. Annu. Rev. Genet. 26:71-112.
28. Petering, H., S. Hammerschmidt, M. Frosch, J. van Putten, C. A. Ison, and B. D. Robertson. 1996. Genes associated with the meningococcal capsule complex are also found in Neisseria gonorrhoeae. J. Bacteriol. 178:3342-3345.
29. Régnier, P., M. Grunberg-Manago, and C. Portier. 1987. Nucleotide sequence of the pnp gene of Escherichia coli encoding polynucleotide phosphorylase. J. Biol. Chem. 262:63-68.
30. Relman, D. A., M. Domenighini, E. Tuomanen, R. Rappuoli, and S. Falkow. 1989. Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence. Proc. Natl. Acad. Sci. USA 86:2637-2641.
31. Roy, C. R., and S. Falkow. 1991. Identification of Bordetella pertussis regu- latory sequences required for transcriptional activation of the fhaB gene and autoregulation of the bvgAS operon. J. Bacteriol. 173:2385-2392.
32. Sambrook, J., E. F. Fritsch, and T. Maniatis. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N. Y.
33. Scarlato, V., B. Arico, A. Prugnola, and R. Rappuoli. 1991. Sequential activation and environmental regulation of virulence genes in Bordetella pertussis. EMBO J. 10:3971-3975.
34. 4 modulation. J. Bacteriol. 173:7401-7404.
35. Simon, R., U. Priefer, and A. Pühler. 1983. A broad host range mobilization system for in vivo genetic engeneering: transposon mutagenesis in gram negative bacteria. Bio/Technology 1:784-791.
36. Sprengart, M. L., E. Fuchs, and A. G. Porter. 1996. The downstream box: an efficient and independent translation initiation signal in Eicherichia coli. EMBO J. 15:665-674.
37. Stainer, D. W., and M. J. Scholte. 1970. A simple chemically defined medium for the production of phase I Bordetella pertussis. J. Gen. Microbiol. 63:7501-7510.
38. Steffen, P., S. Goyard, and A. Ullmann. 1996. Phosphorylated BvgA is sufficient for transcriptional activation of virulence-regulated genes in Bordetella pertussis. EMBO J. 15:102-109.
39. Stibitz, S. 1994. Mutations in the bvgA gene of Bordetella pertussis that differentially affect regulation of virulence determinants. J. Bacteriol. 176:5615-5621.
40. Stibitz, S., and M. S.Yang. 1991. Subcellular localization and immunological detection of proteins encoded by the vir locus of Bordeiella pertussis. J. Bacteriol. 174:4288-4296.
41. Uhl, M. A., and J. F. Miller. 1994. Autophosphorylation and phosphotransfer in the Bordetella pertussis BvgAS signal transduction cascade. Proc. Natl. Acad. Sci. USA 91:1163-1167.
42. Uhl, M. A., and J. F. Miller. 1995. BvgAS is sufficient for activation of the Bordetella pertussis ptx locus in Escherichia coli. J. Bacteriol. 177:6477-6485.
43. Weiss, A. A., and S. Falkow. 1984. Genetic analysis of phase change in Bordetella pertussis. Infect. Immun. 43:263-269.